A5027293712- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Ion Channels and Receptors
- Nicotinic Acetylcholine Receptors Study
- Epilepsy research and treatment
- Herbal Medicine Research Studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
AstraZeneca (United States)
2015-2017
Tufts University
2015
Cambridge Scientific (United States)
2015
AstraZeneca (United Kingdom)
2012
AstraZeneca (Canada)
2012
Montreal Heart Institute
2005-2006
Nagoya University
2005
GABA A receptors form Cl − permeable channels that mediate the majority of fast synaptic inhibition in brain. The K + /Cl cotransporter KCC2 is main mechanism by which neurons establish low intracellular levels, thought to enable GABAergic inhibitory control neuronal activity. However, widely used inhibitor furosemide nonselective with antiseizure efficacy slices and vivo , leading a conflicting scheme how influences synchronization. Here we selective VU0463271 [ N -cyclopropyl-...
TRPV1 was originally characterized as an integrator of various noxious stimuli such capsaicin, heat, and protons. TRPV1-null mice exhibit a deficiency in sensing heat stimuli, suggesting that is one the main sensors on nociceptive primary afferent neurons candidate target for hypersensitivity chronic pain. Several different potent selective antagonists have been developed by more than 50 companies since characterization receptor 1997. A consequence this competitive interest crowding...