A5087168778- RNA modifications and cancer
- Biological Research and Disease Studies
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Biochemical Analysis and Sensing Techniques
- Intraperitoneal and Appendiceal Malignancies
- Advanced biosensing and bioanalysis techniques
- Opioid Use Disorder Treatment
- Cardiac Arrest and Resuscitation
- Hearing, Cochlea, Tinnitus, Genetics
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Omental and Epiploic Conditions
- Pediatric Pain Management Techniques
- RNA Interference and Gene Delivery
- PI3K/AKT/mTOR signaling in cancer
- Enhanced Recovery After Surgery
- Reconstructive Surgery and Microvascular Techniques
- Vascular Anomalies and Treatments
- Body Contouring and Surgery
- Sepsis Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Health Literacy and Information Accessibility
- Cardiac Structural Anomalies and Repair
- Surgical Sutures and Adhesives
Cleveland Clinic Florida
2024
St. Joseph’s University Medical Center
2020-2023
Lake Erie College of Osteopathic Medicine
2017
University of Minnesota
2015
Non-small cell lung cancers (NSCLC) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent in NSCLC, such as mutations PTEN, EGFR, KRAS, and ALK, are detected, at most, only 30% patients. Thus, many unidentified low-penetrant causing a significant portion cancers. To detect low-penetrance drivers forward screen was performed mice using the Sleeping Beauty (SB) DNA transposon random mutagen to generate tumors Pten-deficient background. SB coupled with Pten...
Glutamate is the most abundant excitatory neurotransmitter in central nervous system, and stored released by both neurons astrocytes. Despite important role of glutamate as a neurotransmitter, high levels extracellular can result excitotoxicity apoptosis. Monosodium (MSG) naturally occurring sodium salt glutamic acid that used flavour enhancer many processed foods. Neonatal exposure to MSG has been shown neurodegeneration several forebrain regions, characterised neuronal loss neuroendocrine...
Opioid overdose deaths have increased over the last two decades, despite efforts to reduce prescribing. This study aimed determine if a hospital-wide Alternatives Opiates (ALTO
Background: Social media has become a valuable platform for advertising. Instagram is one of the most popular platforms. Many plastic surgeons have utilized this to promote themselves and their practices. Having followers on can provide validity expand reach potential clients. We aim compare practices top 10 surgeon accounts those with 100,000 followers. Methods: Top were selected using Google search features. Additional feature. Each account was evaluated average number contents posted...
Unlike other body parts, the upper extremity has critical structures close to skin, making soft tissue injuries more complex. These can result from various causes, including trauma and necrotizing infections, necessitating reconstruction. Historically, pedicled flaps groin abdomen were commonly used for reconstruction, but they had limitations, such as need flap division debulking, patient discomfort, stiffness. Free reconstruction become preferred method, it still faces challenges like...
Opioid analgesics remain mainstay of treatment for trauma-related pain despite growing concerns opioid dependency or misuse. The purpose this study was to evaluate prescribing at hospital discharge after traumatic injury.This is a single-center, retrospective analysis patients ≥18 years age admitted ≥24 hours with primary diagnosis injury. Those alcohol use disorder, polysubstance abuse, chronic use, in-hospital mortality were excluded. outcome the incidence prescribed opioids discharge....
Coronavirus Disease 2019 (COVID-19), a global pandemic, is respiratory infection that impairs the lungs among many other organs. We report case of COVID-19 positive patient requiring prolonged mechanical ventilation with nasogastric tube for enteral feeding, leading to esophageal ulcer and hemorrhage, from an aberrant right subclavian artery.
Background Many critically ill patients have invasive arterial catheters inserted for blood pressure monitoring. Whether catheter leveling method and alternative transducer location affect the accuracy of measurements is unknown. Objective To determine whether use locations visual alignment versus laser device significantly measurements. Methods A convenience sample 36 participants were randomly assigned to 1 3 experimental groups with different locations: taped upper arm, next arm a rolled...
<p>Figures S1 through S7. Figure S1: Diagram of alleles. S2: SB expression in lung S3: Kaplan Meier Survival Curves S4: Necropsy Images S5: Thyroid AdCa and Mets. S6: Transposon insertions Cul3. S7: CUL3 PTEN Protein levels knockdown control A549 H2030 cell lines.</p>
<p>Supplemental Table S2 containing list of insertions</p>
<p>Supplemental Tables S1 and S3 through S10. Table S1: Percentage of experimental animals with abnormal growths in tissues other than the lungs S3: Candidate Lung Cancer Genes based on CIS. S4: CIS human ortholog overlap cancer genes. S5: Ingenuity Pathway Analysis significant canonical pathways 3 or more molecules. S6: Sets genes transposon insertions multiple mice frequent itemset mining. S7: Differentially expressed A549 cells CUL3, PTEN, CUL3 PTEN knocked down. S8: NRF2 pathway...
<p>Supplemental Methods</p>
<p>Supplemental Methods</p>
<p>Supplemental Tables S1 and S3 through S10. Table S1: Percentage of experimental animals with abnormal growths in tissues other than the lungs S3: Candidate Lung Cancer Genes based on CIS. S4: CIS human ortholog overlap cancer genes. S5: Ingenuity Pathway Analysis significant canonical pathways 3 or more molecules. S6: Sets genes transposon insertions multiple mice frequent itemset mining. S7: Differentially expressed A549 cells CUL3, PTEN, CUL3 PTEN knocked down. S8: NRF2 pathway...
<p>Figures S1 through S7. Figure S1: Diagram of alleles. S2: SB expression in lung S3: Kaplan Meier Survival Curves S4: Necropsy Images S5: Thyroid AdCa and Mets. S6: Transposon insertions Cul3. S7: CUL3 PTEN Protein levels knockdown control A549 H2030 cell lines.</p>
<p>Supplemental Table S2 containing list of insertions</p>
<div>Abstract<p>Non–small cell lung cancers (NSCLC) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent in NSCLC, such as mutations <i>PTEN</i>, <i>EGFR</i>, <i>KRAS</i>, and <i>ALK</i>, are detected, at most, only 30% patients. Thus, many unidentified low-penetrant causing a significant portion cancers. To detect low-penetrance drivers forward screen was performed mice using the Sleeping Beauty...
<div>Abstract<p>Non–small cell lung cancers (NSCLC) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent in NSCLC, such as mutations <i>PTEN</i>, <i>EGFR</i>, <i>KRAS</i>, and <i>ALK</i>, are detected, at most, only 30% patients. Thus, many unidentified low-penetrant causing a significant portion cancers. To detect low-penetrance drivers forward screen was performed mice using the Sleeping Beauty...
Pseudomyxoma peritonei (PMP) is a rare disease that most commonly results from the rupture of an appendiceal mucinous neoplasm. It characterized by ascites disseminates throughout abdomen and pelvis, at times to inguinal canal, in which some patients may complain hernia as initial complaint. The incidence PMP with concomitant reported be 7.3-9.6% current literature. We report 70-year-old Hispanic male who initially presented signs right hernia, on computed tomography (CT) scan, was...
Mesothelioma is a disease process that can present in variety of locations including the pleural, peritoneum and pericardium. Malignant peritoneal mesothelioma has been known to be particularly aggressive type tumor. We report case patient who presented with small bowel obstruction whose pathology revealed malignant mesothelioma.
Johnston, Jackie; Nerenberg, Steven; LaPietra, Alexis; Wang, Antai; Kulig, Caitlin; Foran, Lindsey; Hlayhel, Ahmad; Yang, James; Parmar, Dinesh; Elsawy, Osama Author Information