A5099022232- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
Miami University
2024
Abstract Patients diagnosed with posttraumatic stress disorder (PTSD) present a spectrum of debilitating anxiety symptoms resulting from exposure to trauma. Women are twice as likely be and PTSD compared men; however, the reason for this vulnerability remains unknown. We conducted four experiments where we first demonstrated female stress‐enhanced fear learning (SEFL) moderate, acute early life (aELS) (4 footshocks in single session), more intense aELS (15 session) males females comparable...
Individuals diagnosed with stress-related psychiatric disorders in adulthood are likely to have experienced early life stress, suggesting that adversity is an important vulnerability factor the subsequent development of trauma- and anxiety-related illness. It develop animal models dysfunction determine evident considerations, potential biomarkers, novel treatment avenues improve human condition. In our model acute stress (aELS), 15 footshocks delivered a single session on postnatal day 17....
Background/Objectives: Rodents provide a useful translational model of fear- and anxiety-related behaviors. Previously stressed animals exhibit physiological behavioral stress responses that parallel those observed in anxious humans. Patients diagnosed with post-traumatic disorder (PTSD) present spectrum debilitating anxiety symptoms result from exposure to one or more traumatic events, individuals exposed early adverse experiences women having increased vulnerability for diagnoses; however,...