A5073917431- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Trigeminal Neuralgia and Treatments
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Fractures and Fixation Techniques
- S100 Proteins and Annexins
- Facial Nerve Paralysis Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Moyamoya disease diagnosis and treatment
- Spinal Dysraphism and Malformations
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Surgical Simulation and Training
- Atrial Fibrillation Management and Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
International University of Health and Welfare
2020-2025
Japanese Red Cross Narita Hospital
2022-2024
Saga University
2024
Stony Brook University
2022
Neurological Surgery
2022
Shinshu University
2022
Yamaguchi University
2011-2022
Yamaguchi University Hospital
2014-2021
The Japanese Society of Gastroenterological Surgery
2021
Tokyo Women's Medical University Adachi Medical Center
2013
Background: Patients with previous abdominal surgeries are often considered unsuitable for lumboperitoneal (LP) or ventriculoperitoneal shunt placement due to the potential risk of peritoneal adhesions. This study evaluates safety and efficacy lateral approach LP insertion in such patients. Methods: A retrospective analysis was performed on 21 patients who underwent idiopathic normal pressure hydrocephalus (iNPH) via at our institution between January 2021 December 2022. We reviewed patient...
Recent experimental data have shown that levels of matrix metalloproteinase-9 (MMP-9) increase after traumatic brain injury (TBI), degrading components the basal lamina disrupting blood-brain barrier. However, post-traumatic secretion patterns MMP-9 in humans are unknown. We measured concentration plasma TBI at same time as interleukin-6 (IL-6) serum. Levels and IL-6 systemic arterial jugular venous blood from seven patients with were on days 0 1 post-injury. All underwent hypothermia 32-35...
<i>Background:</i> The management of patients with poor-grade subarachnoid hemorrhage (SAH) continues to be controversial. objective this study was examine predictors outcome SAH after surgical obliteration the aneurysm. <i>Methods:</i> performed as a retrospective review 283 who underwent aneurysm at multiple centers in Chugoku and Shikoku, Japan. <i>Results:</i> A favorable discharge achieved 97 (34.3%). Age (p < 0.001), World Federation Neurosurgical...
Systemic circulation management has not been established for patients with poor grade aneurysmal subarachnoid hemorrhage (SAH) or delayed cerebral ischemia (DCI) after SAH. The aims of the study were to examine hemodynamic variables in these and establish treatment strategies.A multicenter prospective cohort from days 1 14 was performed using a transpulmonary thermodilution system (PiCCO Plus). Parameters analyzed by Mann-Whitney test. Multivariate analysis identify parameters involved onset...
Objective Traditionally, angiographic vasospasm (aVS) has been thought to cause delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). However, successful treatment of aVS alone does not result in improved neurological outcome. Therefore, there may be other potential causes poor outcome, including spreading depolarization (SD). A recent study showed beneficial effects cilostazol on DCI and The present prospective clinical trial experimental focused SDs. Methods...
Object. Although considerable attention has been focused on the use of posttraumatic hypothermia, little consideration given to issue posthypothermic rewarming and its potentially damaging consequences. In this communication, authors examine rapid compared with gradual while exploring potential utility cyclosporin A (CsA) administration for attenuating any rewarming—induced axonal change. Methods. Male Sprague—Dawley rats were subjected impact-acceleration injury then their body temperature...
The purpose of this study was to examine the effects mild hypothermia and hyperthermia on glutamate excitotoxicity. Glutamate-induced cortical lesions were produced in hypothermic (32°C), normothermic (37°C), hyperthermic (40°C) rats by perfusion a 0.5 M solution via microdialysis probe. volume lesion 7 days after quantified histologically image analysis. This histological assessment performed two experiments; one, each target temperatures induced before perfusion, other, stopping perfusion....
In the clinical and laboratory setting, multiple reports have suggested efficacy of hypothermia in blunting damaging consequences traumatic brain injury (TBI). With use posttraumatic hypothermia, it has been recognized that time initiation duration are important variables determining degree neuroprotection provided. Further, recently rate rewarming is an variable, with rapid exacerbating neuronal/axonal damage contrast to slow which appears provide enhanced neuroprotection. Although these...
Summary Objective Recently, focal brain cooling ( FBC ) was proposed as a method for treating refractory epilepsy. However, the precise influence of on molecular basis epilepsy has not been elucidated. Thus aim this study to assess effect glutamate (Glu) concentration, cerebral blood flow CBF ), and glucose metabolism in patients with intractable Methods Nine underwent at 15°C 30 min prior cortical resection (n = 6) or hippocampectomy 3). Measurement metabolites , well electrocorticography...
Neurological deterioration after mild traumatic brain injury (TBI) has been recognized as a poor prognostic factor. Early detection of neurological would allow appropriate monitoring and timely therapeutic interventions to improve patient outcomes. In this study, we developed machine learning model predict the occurrence TBI using information obtained on admission. This was retrospective cohort study data from Think FAST registry, multicenter prospective observational elderly patients in...
Abdominal cerebrospinal fluid (CSF) pseudocysts are rare complications of shunt surgery, predominantly reported in pediatric patients undergoing a ventriculoperitoneal (VP) shunt. In contrast, their occurrence following lumboperitoneal (LP) is exceptionally uncommon. We report the case 76-year-old woman who presented with recurrent symptoms, including gait disturbance and cognitive decline, approximately three years after LP placement for idiopathic normal pressure hydrocephalus. Diagnostic...
Spontaneous acute subdural hematoma (SDH) is a rare but potentially life-threatening condition. We present the case of 73-year-old man with spontaneous SDH in which computed tomography angiography (CTA) demonstrated contrast extravasation from cortical artery. The patient was successfully treated endoscopic evacuation via small craniotomy, minimizing surgical invasiveness. This highlights value CTA as an essential initial imaging modality for identifying bleeding source and guiding...
Traditional surgical education faces challenges such as limited visibility, physical space constraints, and restricted access for students. Virtual reality (VR) technology offers a promising alternative, especially with real-life 360-degree video, which can recreate immersive clinical experiences. This study investigates whether VR enhance medical students' interest in neurosurgery serve an effective educational tool. A VR-based program was developed using video footage captured Insta360 Pro...
Ebselen is a mimic of glutathione peroxidase that reacts with peroxynitrite and inhibits nitric oxide (NO) synthase. has beneficial effects on the neurological outcome patients stroke. In this study, mechanisms by which ebselen can elicit neuroprotective against ischemic brain injury were investigated in male Wistar rats. Experimental forebrain ischemia was induced bilateral common carotid artery occlusion hemorrhagic hypotension. administered to animals treatment group 2 hours prior...
A multicenter randomized controlled trial of patients with severe traumatic brain injury who received therapeutic hypothermia or fever control was performed from 2002 to 2008 in Japan (BHYPO). There no difference the effect on between two groups. The efficacy treatment and objective were reexamined based a secondary analysis BHYPO 135 (88 treated 47 control). This examine clinical outcomes according CT classification Traumatic Coma Data Bank admission. Clinical evaluated Glasgow Outcome...
The harmful effects of hyperoxemia have been reported in critically ill patients with various disorders, including those brain injuries. However, the effect on aneurysmal subarachnoid hemorrhage (aSAH) is unclear. In this study authors aimed to determine whether during hyperacute or acute phase aSAH associated delayed cerebral ischemia (DCI) and poor neurological outcome.
BackgroundAcute exacerbation of head injury in elderly patients due to use antithrombotic agents has become a concern countries with aging populations. Reversal are recommended for treatment, but its usage is unclear. Therefore, we conducted prospective observational study this patient population monitor reversal therapy.MethodsThe subjects were 721 aged ≥65 years old who hospitalized 15 centers from December 2019 May 2021. Patients divided into groups did not receive (Group A), received...
Recently, we focused on the cerebrovascular protective effects of moderate hypothermia after traumatic brain injury, noting that efficacy posttraumatic is related to rate posthypothermic rewarming. In current communication, revisit use with varying degrees rewarming ascertain whether, in normal cerebral vasculature, rates can differentially affect responsiveness.Pentobarbital-anesthetized rats equipped a cranial window were randomized 3 groups. 1 group, 1-hour period (32 C) followed by slow...
We evaluated cortical damages following traumatic brain injury (TBI) in the acute phase with [(123)I] iomazenil (IMZ) single photon emission computed tomography (SPECT). In all, 12 patients cerebral contusion TBI were recruited. All underwent IMZ SPECT within 1 week after TBI. To investigate changes distribution of cortex chronic phase, conventional treatment, again. A decrease accumulation radioligand for central benzodiazepine receptor corresponding to revealed (CT) scans and magnetic...