A5019496497- Immune Cell Function and Interaction
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Inflammasome and immune disorders
- Escherichia coli research studies
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis Viruses Studies and Epidemiology
- Herpesvirus Infections and Treatments
- Gastrointestinal motility and disorders
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Gut microbiota and health
- Cytomegalovirus and herpesvirus research
- Parasitic Infections and Diagnostics
- Parasites and Host Interactions
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Amoebic Infections and Treatments
University of Chicago
2011-2017
NK-derived cytokines play important roles for natural killer (NK) function, but how the are regulated is poorly understood. CD160 expressed on activated NK or T cells in humans its function unknown. We generated CD160-deficient mice to probe function. Although CD160−/− showed no abnormalities lymphocyte development, control of NK-sensitive tumors was severely compromised mice. Surprisingly, cytotoxicity not impaired, interferon-γ (IFN-γ) secretion by markedly reduced Functionally targeting...
Abstract Host anti-viral innate immunity plays important roles in the defense against HSV-1 infection. In this study, we find an unexpected role for LT/LIGHT signaling promoting replication and virus induced inflammation immunocompromised mice. Using a model of footpad infection Rag1 –/– mice, observed that blocking with LTβR-Ig could significantly delay disease progression extend survival infected treatment reduced late proinflammatory cytokine release serum nervous tissue inhibited...
The immunological components that control resolution of Salmonella infection and successful vaccination are poorly defined. In a model chronic gastrointestinal infection, we observed the lymphotoxin (LT) pathway is essential for clearance primary attenuated enterica Typhimurium strain SL3261 ΔaroA Using gnotobiotic mice, show LTβ receptor (LTβR) signaling microbiota required to promote S. from gut lumen. We also found LTβR was immunization subsequent protection upon challenge with virulent S...
How some bacteria evade the immune system to cause persistent infection is unclear. Oral vaccination against bacterial pathogens could limit lethal but pathways that generate protective immunity are poorly understood. Using streptomycin pretreatment and oral with live, attenuated Salmonella establish colonization of mice, we demonstrate lymphotoxin pathway essential for generation infection. Lymphotoxin beta receptor (LTβR) deficient mice have normal initial in gut fail achieve clearance...
Abstract Worldwide endemic infection with gastrointestinal helminths is a potential challenge to successful vaccination in underdeveloped regions. In the current study we demonstrate that natural murine pathogen H. bakeri significantly reduced serum antibody responses both parenteral immunization ovalbumin (OVA) adsorbed alum and oral an attenuated OVA-expressing Salmonella strain. The reduction correlates helminth-mediated increase proportions of IL-10 secreting CD4+FoxP3+Tregs...