A5006470790- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Sirtuins and Resveratrol in Medicine
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Genomics, phytochemicals, and oxidative stress
- Toxin Mechanisms and Immunotoxins
- Wound Healing and Treatments
- Cancer Genomics and Diagnostics
- Metal complexes synthesis and properties
- Chromosomal and Genetic Variations
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Nanoparticle-Based Drug Delivery
- Multiple Myeloma Research and Treatments
- PARP inhibition in cancer therapy
- Synthesis and biological activity
Toronto General Hospital
2019-2020
: Cancer and inflammatory disorders are two important public health issues worldwide with significant socio.economic impacts. Despite several efforts, the current therapeutic platforms associated severe limitations. Therefore, developing new strategies for treatment of these diseases is a top priority. Besides therapies, utilization natural compounds has emerged as horizon cancer well. Such could be used either alone or in combination standard modalities such chemotherapy, radiotherapy,...
: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence melanoma has steadily increased. Metastatic greatly resistant to standard antimelanoma treatments such as chemotherapy, 5-year survival rate cases with who have a metastatic form disease less than 10%. contributing role apoptosis, angiogenesis autophagy in pathophysiology been previously demonstrated. Thus, it extremely urgent search for complementary therapeutic approaches that could enhance...
Background: Genetic heterogeneity in multiple myeloma (MM) affects not only the disease development but also therapeutic response and prognosis. Nowadays, karyotype FISH are standard diagnostic tools for detection of genetic aberrations MM. However, comprehensive analysis genome architecture, particularly structural variations (SVs), still remain a challenge. Aims: To study genomic architecture MM cells using novel nanochannel technology based on optical mapping high-molecular weight DNA...