A5087320552- Natural product bioactivities and synthesis
- Ubiquitin and proteasome pathways
- Pulsars and Gravitational Waves Research
- Bioactive natural compounds
- Bioactive Compounds in Plants
- Biological Activity of Diterpenoids and Biflavonoids
- Mycotoxins in Agriculture and Food
- Probiotics and Fermented Foods
- Geophysics and Gravity Measurements
- Cancer-related Molecular Pathways
- Antibiotic Resistance in Bacteria
- Cancer, Hypoxia, and Metabolism
- Bacteriophages and microbial interactions
- Carcinogens and Genotoxicity Assessment
- NF-κB Signaling Pathways
- Atomic and Subatomic Physics Research
- Curcumin's Biomedical Applications
- Polysaccharides and Plant Cell Walls
- Flavonoids in Medical Research
- Ferroptosis and cancer prognosis
- Shoulder and Clavicle Injuries
- Glycosylation and Glycoproteins Research
- Cancer, Stress, Anesthesia, and Immune Response
- Bioactive Natural Diterpenoids Research
- Photodynamic Therapy Research Studies
University of Oklahoma Health Sciences Center
2022-2024
Daegu University
2018-2023
New York University
2022
R. G. Kar Medical College and Hospital
2021
Medical College and Hospital, Kolkata
2021
Bankura Sammilani Medical College
2021
National Institute of Animal Nutrition and Physiology
2020
Barkatullah University
2015
Polymethoxyflavanoids (PMFs) have exhibited a vast array of therapeutic biological properties. 5-O-Demethylnobiletin (5-DN) is one such PMF having anti-inflammatory activity, yet its role in hepatoprotection has not been studied before. Results from vitro study revealed that 5-DN did exert high level cytotoxicity on HepG2 cells at 40 μM, and it was able to rescue cell death induced by carbon tetrachloride (CCl4). Subsequently, we investigated acute liver injury BALB/c mice CCl4 through the...
Phorbol 12-myristate 13-acetate (PMA) is a potent tumor promoter and highly inflammatory in nature. Here, we investigated the toxic effects of PMA on different model system. (10 μg) caused chromosomal aberrations Allium cepa root tip induced mitotic dysfunction. Similarly, embryonic larval deformities plummeted survivability rate zebrafish embryo dose-dependent manner. Persistently, treatment immortalized human keratinocyte (HaCaT) cells massive rush at 4 h drop cell 24 h. Concomitantly,...
Hypoxia is a feature of solid tumors that greatly hinders cancer treatment. Here, we developed hypoxia-responsive nanoparticles (NPs) selectively release chlorin e6 (Ce6) and paclitaxel (PTX) under hypoxic conditions. To prepare the NPs, PTX-loaded HSA NPs (PHNPs) were functionalized with 4,4′-azodianiline (Azo) as linker for PHNPs Ce6 (CA/PHNPs). The CA/PHNPs then RGD-conjugated poly(ethylene glycol) (RP/CA/PHNPs). azo group (-NN-) present in Azo was reductively cleaved conditions to PTX....
Endometrial cancer is the most common female showing continuous rise in its incidence and mortality rate. Despite extensive research efforts therapeutics, still there a lack of effective treatment options outcome poor for patients with advanced recurrent endometrial cancers. In this study, we aimed to evaluate efficacy niclosamide (NIC) against cancer. NIC an FDA-approved anti-helminthic drug, which has been recently extensively studied as potent anti-cancerous agent several The activity was...
For the first time, we analyze impact of dark matter (DM) on curvature properties quarkyonic neutron stars (NS) using a hybrid model based quarkyonic-effective field theory within relativistic mean-field (E-RMF) framework. This study examines radial variation components, including Ricci scalar ($\cal{R}$), tensor ($\cal{J}$), Kretschmann ($\cal{K}$), and Weyl ($\cal{W}$), under different DM admixtures. These components offer critical insights into spacetime geometry gravitational strength...
RNA binding proteins (RBPs) associate with nascent and mature RNAs to perform biological functions such as alternative splicing stability. Having unique recognition motifs, RBPs form complexes in a sequence- structure-based manner. Aberrant expressions of several have been identified tumorigenesis cancer progression. These uncontrolled affect mechanisms, including cell proliferation, tumor growth, invasion, metastasis chemoresistance. Epithelial regulatory protein 1 (ESRP1) is member the...
Cisplatin, a powerful chemotherapy medication, has long been cornerstone in the fight against cancer due to chemotherapeutic failure. The mechanism of cisplatin resistance/failure is multifaceted and complex issue that consists mainly apoptosis inhibition through autophagy sensitization. Currently, researchers are exploring ways regulate order tip balance favor effective chemotherapy. Based on this notion, current study primarily identifies differentially expressed genes (DEGs)...
A visual experiment was conducted to investigate the antimicrobial potential of cell-free culture supernatant Weissella confusa (DD_A7) against foodborne pathogenic bacteria Escherichia coli 0157: H7 by disc diffusion method. The result revealed that DD_A7 exerted effective antibacterial control growth E. upon treatment with 100 µg/mL supernatant. This study demonstrated is a potent probiotic candidate reduce risk factor associated Shiga toxin-producing coli.
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The formulation of quarkyonic matter consists treating both quarks and nucleons as quasi-particles, where a cross-over transition occurs between the two phases. This work is based upon some early ideas quark matter. It can satisfy different observational constraints on neutron star (NS), such its maximum mass canonical radius. In addition, we put an extra component inside NS known Dark Matter (DM) because it trapped due to immense gravitational potential. this work, explore impact fermionic...