A5080780761- Neuroinflammation and Neurodegeneration Mechanisms
- Vagus Nerve Stimulation Research
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Cancer, Stress, Anesthesia, and Immune Response
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Single-cell and spatial transcriptomics
- Circadian rhythm and melatonin
- Pain Management and Placebo Effect
- Olfactory and Sensory Function Studies
- Congenital Ear and Nasal Anomalies
- Ion-surface interactions and analysis
- Nicotinic Acetylcholine Receptors Study
- Radiation Detection and Scintillator Technologies
- Neurological disorders and treatments
- Particle Detector Development and Performance
- Platelet Disorders and Treatments
- T-cell and B-cell Immunology
- German Literature and Culture Studies
- Cardiovascular Effects of Exercise
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- EEG and Brain-Computer Interfaces
Technion – Israel Institute of Technology
2013-2021
Single-cell analysis of CD4 T cells reveals a population structure associated with inflammation and declined immunity in aging.
Abstract Regulating immunity is a leading target for cancer therapy. Here, we show that the anti-tumor immune response can be modulated by brain’s reward system, key circuitry in emotional processes. Activation of system tumor-bearing mice (Lewis lung carcinoma (LLC) and B16 melanoma) using chemogenetics (DREADDs), resulted reduced tumor weight. This effect was mediated via sympathetic nervous (SNS), manifested an attenuated noradrenergic input to major immunological site, bone marrow....
The sympathetic nervous system is composed of an endocrine arm, regulating blood adrenaline and noradrenaline, a local network fibers innervating immune organs. Here, we investigated the impact arm SNS in inflammatory response colon. Intra-rectal insertion optogenetic probe mice engineered to express channelrhodopsin-2 tyrosine hydroxylase cells activated colonic fibers. In contrast systemic application activation attenuated experimental colitis reduced cell abundance. Gene expression...
Abstract Increasing evidence indicates that the brain regulates peripheral immunity. Yet, it remains unclear whether and how represents state of immune system. Here, we show immune-related information is stored in brain’s insular cortex (InsCtx). Using activity-dependent cell labeling mice ( Fos TRAP ) , captured neuronal ensembles InsCtx were active under two different inflammatory conditions (DSS-induced colitis Zymosan-induced peritonitis). Chemogenetic reactivation these was sufficient...
Einführung: Das Radfahren Querschnittgelähmter ist mithilfe künstlich erzeugter Stimulationsmuster (Einschaltreihenfolge der Beinmuskeln) realisierbar. Eine Optimierung dieser individuell für den einzelnen Patienten berechneten Muster könnte zu Leistungserhöhungen beim und besserem kardiovaskulären Muskel-Training führen.