A5014926597- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Peroxisome Proliferator-Activated Receptors
- Retinal and Optic Conditions
- S100 Proteins and Annexins
- Phagocytosis and Immune Regulation
- Retinal Diseases and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mast cells and histamine
Helsinki University Hospital
2015-2019
University of Helsinki
2014-2019
University of Pittsburgh
2019
Helsinki Art Museum
2018
Wihuri Research Institute
2014-2018
Kuopio University Hospital
2016
University of Eastern Finland
2016
Finland University
2016
Inhibition of prostaglandin E 2 signaling in macrophages may be a pharmacological option for treating intracranial aneurysms.
<h3>BACKGROUND AND PURPOSE:</h3> Saccular intracranial aneurysm is a common disease that may cause devastating hemorrhage. Hemodynamics, wall remodeling, and inflammation have been associated with saccular rupture. We investigated how hemodynamics remodeling of the wall. <h3>MATERIALS METHODS:</h3> Tissue samples resected during operation (11 unruptured, 9 ruptured) were studied histology immunohistochemistry. Patient-specific computational models created from preoperative CT angiographies....
Chronic inflammation contributes to remodeling, degeneration, and rupture of saccular intracranial artery aneurysms. Mast cells are important proinflammatory proangiogenic in chronic inflammatory vascular diseases. Here we studied mast neovascularization 36 intraoperatively resected aneurysms using histology immunohistochemistry analyzed the clinical characteristics according bleeding status (unruptured vs ruptured). Among aneurysms, 9 contained (tryptase-positive cells) 15 neovessels (CD34-...
Saccular intracranial aneurysm (sIA) causes hemorrhages that are associated with high mortality. Lipid accumulation and chronic inflammation occur in the sIA wall. A major mechanism for lipid clearance from arteries is adenosine triphosphate-binding cassette A1 (ABCA1)-mediated efflux foam cells to apolipoprotein A-I (apoA-I). We investigated association of wall degeneration, inflammation, lipid-related parameters tissue samples 16 unruptured 20 ruptured sIAs using histology...
Rupture of a saccular intracranial aneurysm (sIA) is often fatal. Thus, early detection rupture-prone sIAs vital. Myeloperoxidase (MPO), derived mainly from neutrophils, associates with sIA rupture, and therefore its role in pathogenesis warrants further studies. We analyzed MPO association other histological markers 36 (16 unruptured 20 ruptured) samples by immunohistochemistry. was present all studied sIAs, expression associated wall inflammatory cell infiltrations (r = 0.50, 0.63, 0.75, p...
Although the clinical and biological importance of calcification is well recognized for extracerebral vasculature, its role in cerebral vascular disease, particularly, intracranial aneurysms (IAs), remains poorly understood. Extracerebrally, 2 distinct mechanisms drive calcification, a nonatherosclerotic, rapid mineralization media slower, inflammation driven, atherosclerotic mechanism intima. This study aims to determine prevalence, distribution, type (atherosclerotic, nonatherosclerotic)...
Saccular intracranial aneurysm (sIA) rupture is often fatal. Rupture-prone sIA walls are infiltrated by macrophages expressing hemoglobin-receptor CD163, suggesting a role for erythrocyte lysis in the degenerative remodeling predisposing to rupture. We therefore studied remnants 16 unruptured and 20 ruptured using histology immunohistochemistry. Glycophorin A (GPA), an membrane protein, was present 34/36 (94%) correlated with loss of αSMA+ cells, reflecting mural smooth muscle cells ([SMCs];...