A5074163552- Skin and Cellular Biology Research
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Dermatology and Skin Diseases
- Cellular Mechanics and Interactions
- Psoriasis: Treatment and Pathogenesis
- Contact Dermatitis and Allergies
- Polysaccharides and Plant Cell Walls
- Exercise and Physiological Responses
- Advancements in Transdermal Drug Delivery
- Cell Adhesion Molecules Research
Seoul National University
2016-2022
Seoul National University Hospital
2016-2022
Skullcapflavone II (SFII), a flavonoid derived from Scutellaria baicalensis, has been reported to have anti-inflammatory properties. However, its therapeutic potential for skin inflammatory diseases and mechanism are unknown. Therefore, this study aimed investigate the effect of SFII on TNF-α/IFN-γ-induced atopic dermatitis (AD)-associated cytokines, such as thymus- activation-regulated chemokine (TARC) macrophage-derived (MDC). Co-stimulation with TNF-α/IFN-γ in HaCaT cells is...
Proteoglycan (PG) is a glycosaminoglycan (GAG)-conjugated protein essential for maintaining tissue strength and elasticity. The most abundant skin PGs, biglycan decorin, have been reported to decrease as ages. Insulin-like growth factor-1 (IGF-1) important in various physiological functions such cell survival, growth, apoptosis. It well known that the serum level of IGF-1 decreases with age. Therefore, we investigated whether how affects decorin. When primary cultured normal human dermal...