A5009661050- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Gut microbiota and health
- Cardiovascular Disease and Adiposity
- Apelin-related biomedical research
- Mitochondrial Function and Pathology
- Nutritional Studies and Diet
- Exercise and Physiological Responses
- Hormonal Regulation and Hypertension
Universidade do Estado do Rio de Janeiro
2020-2025
Humanitas University
2019
Creative Research Enterprises (United States)
2019
To examine the effects of a selective peroxisome proliferator-activated receptor (PPAR-α) agonist treatment on interscapular brown adipose tissue (iBAT) whitening, focusing thermogenic, lipolysis, and lipid oxidation markers in mice fed high-fat or high-fructose diet. Fifty animals were randomly assigned to receive control diet (C, 10% lipids as energy), (HF, 50% (HFRU, fructose energy) for 12 wk. Each group was redivided begin 5-wk treatment, totaling five experimental groups: C, HF, HF-a,...
Fructose dietary intake affects the composition of intestinal microbiota and influences development hepatic steatosis. Endotoxins produced by gram-negative bacteria alter permeability cause bacterial translocation. This study evaluated effects gut modulation a purified PPAR-alpha agonist (WY14643), DPP-4 inhibitor (linagliptin), or their association on barrier integrity, endotoxemia, energy metabolism in high-fructose-fed C57BL/6 mice. Fifty mice were divided to receive control diet (C...
Obesity and comorbidities onset encompass gut dysbiosis, altered intestinal permeability, endotoxemia. Treatments that target dysbiosis can cope with obesity nonalcoholic fatty liver disease (NAFLD) management. Peroxisome proliferator-activated receptor (PPAR)-alpha activation dipeptidyl-peptidase-4 (DPP-4) inhibition alleviate NAFLD, but the mechanism may involve microbiota modulation merits further investigation.To address effects of PPAR-alpha DPP-4 (isolated or combined) upon gut-liver...
Obesity has been associated with hepatic overexpression of the renin-angiotensin system (RAS).To evaluate action two angiotensin II (ANGII) receptor blockers (losartan or telmisartan) on modulation local RAS and resulting metabolic effects in a diet-induced obesity murine model.Twenty C57BL/6 mice were randomly divided into nutritional groups for 10 wk: control group (C, n = 5, 10% energy as fat) high-fat (HF, 15, 50% fat). After treatment started, HF was three groups: untreated (n 5),...
Obesity causes white and brown adipocyte dysfunction, reducing browning stimulating whitening. Drugs that tackle dysfunction through thermogenesis stimulation could be used to treat obesity. This study sought address whether a combination of the PPAR-alpha agonist (WY14643) DPP4i (linagliptin) potentiates mitigates adipose tissue emphasizing pathways related induction underlying in high-fat-fed mice. Adult male C57BL/6 mice were randomly assigned receive control diet (C, 10% lipids) or...
Excessive saturated fat intake compromises the integrity of intestinal mucosa, leading to low-grade inflammation, impaired mucosal integrity, and increased permeability, resulting in migration lipopolysaccharide (LPS) other tissues.
The rising fructose intake in sugar-sweetened beverages and ultra-processed foods relates to the high incidence of nonalcoholic fatty liver disease. This study aimed examine effects long-term high-fructose diet (for 16 or 20 weeks) on progressive hepatic damage, focusing endoplasmic reticulum stress markers fibrogenesis as possible triggers fibrosis. Forty 3-month-old male C57BL/6J mice were randomly divided into four nutritional groups: C16 (control for weeks), C20 HFRU16 (high-fructose...
Objective: This study aimed to evaluate the differential role of a high-fat diet (HF) or high-fructose (HFRU) on white adipose tissue and brown remodeling in C57BL/6 mice.Methods: The animals were randomly assigned receive HF (50% energy as lipids), HFRU fructose), control (C, 10% lipids) for 12 weeks. Results: group became overweight from 7th week onwards, but both groups showed hyperinsulinemia, oral glucose intolerance, adverse remodeling. interscapular whitening, tough reduced QA...