A5062416945- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Nail Diseases and Treatments
- IL-33, ST2, and ILC Pathways
- Whipple's Disease and Interleukins
- Trypanosoma species research and implications
- Bacterial Infections and Vaccines
- Herbal Medicine Research Studies
- Cytomegalovirus and herpesvirus research
- Asthma and respiratory diseases
- Galectins and Cancer Biology
- Autoimmune and Inflammatory Disorders Research
- Research on Leishmaniasis Studies
- Parasitic Infections and Diagnostics
- COVID-19 and healthcare impacts
- Studies on Chitinases and Chitosanases
- Cytokine Signaling Pathways and Interactions
- Mobile Health and mHealth Applications
- Mosquito-borne diseases and control
- Food Security and Health in Diverse Populations
- Pediatric health and respiratory diseases
- Peptidase Inhibition and Analysis
- Complement system in diseases
Virginia–Maryland College of Veterinary Medicine
2019-2023
University of Maryland, College Park
2019-2023
Vidant Medical Center
2020
University of Baltimore
2018
Johns Hopkins University
2018
Johns Hopkins Medicine
2018
Abstract Allergic asthma is a disease initiated by breach of the lung mucosal barrier and an inappropriate Th2 inflammatory immune response that results in M2 polarization alveolar macrophages (AM). The number airway correlates with severity humans. Sex differences suggest sex hormones modify inflammation macrophage polarization. Asthmatic women have more than asthmatic men androgens been used as experimental treatment. In this study, we demonstrate although androgen (dihydrotestosterone)...
Fungal dissemination into the bloodstream is a critical step leading to invasive fungal infections. Here, using intravital imaging, we show that Kupffer cells (KCs) in liver have prominent function capture of circulating Cryptococcus neoformans and Candida albicans, thereby reducing target organs. Complement C3 but not C5, complement receptor CRIg CR3, are involved C. neoformans. Internalization by KCs subsequently mediated multiple receptors, including CRIg, scavenger which work...
Significance Bloodborne parasites develop very sophisticated mechanisms to survive in the bloodstream, causing serious diseases. The involved intravascular clearance of bloodborne are largely unknown. Understanding underlying is fundamental for developing strategies treat In current study, we reveal that CRIg, a macrophage receptor previously shown bind C3b/iC3b vitro, plays an essential role African trypanosomes. More importantly, demonstrate through interactions with complement deposited...
How lung macrophages, especially interstitial macrophages (IMs), respond to invading pathogens remains elusive. Here, we show that mice exhibited a rapid and substantial expansion of CX3CR1
Monocytes exist in two major populations, termed Ly6Chi and Ly6Clow monocytes. Compared to monocytes, less is known about monocyte recruitment mechanisms involved the of this subset. Furthermore, role monocytes during infections largely unknown. Here, using intravital microscopy, we demonstrate that are predominantly recruited brain vasculature following intravenous infection with Cryptococcus neoformans, a fungal pathogen causing meningoencephalitis. The depends primarily on interaction...
TNF/iNOS-producing dendritic cells (Tip-DCs) are at the front line as immune effector to fight off a broad range of invading microbes. Excessive development Tip-DCs contributes tissue destruction.
Liver macrophages internalize circulating bloodborne parasites. It remains poorly understood how this process affects the fate of and T cell responses in liver. Here, we report that infection by Trypanosoma brucei induced depletion liver, leading to repopulation CXCL16-secreting intrahepatic macrophages, associated with substantial accumulation CXCR6 + CD4 cells Interestingly, disruption signaling did not affect control parasitemia, but significantly enhanced survival infected mice, reduced...
Abstract Aspergillus fumigatus is an opportunistic fungal pathogen that causes a wide spectrum of diseases in humans, including life-threatening invasive infections as well several hypersensitivity respiratory disorders. Disease prevention predicated on the host’s ability to clear A. from lung while also limiting inflammation and preventing allergic responses. IL-27 important immunoregulatory cytokine, but its role during infection remains poorly understood. In contrast most settings...
Migration of Cryptococcus neoformans from the blood to brain parenchyma is crucial cause fatal meningoencephalitis. Although mechanisms involved in migration C. have been widely studied vitro, less known about how fungus crosses blood–brain barrier (BBB) vivo. This part because lack an approach quantitatively analyse dynamics fungal transmigration into across BBB In this study, we report a novel interactions between and endothelial cells mouse model using flow cytometry. Using system, show...
Abstract Allergic asthma is an inappropriate Th2 immune response in the lungs to innocuous inhaled antigens. This results M2 polarization of alveolar macrophages (AM), which number correlates with severity humans. Sex differences suggest that sex hormones modify lung inflammation and macrophage polarization. Since estrogen enhances androgens have been used as experimental therapy, we hypothesized [testosterone dihydrotestosterone (DHT)] androgen receptor (AR) suppress Here, demonstrate...
We, registered dietitian nutritionists (RDNs), could have sat on the sidelines in early days of pandemic when many RDNs were not considered “essential” workers. Instead, used their abilities to innovate and adapt ensure public, patients, clients received continuous nutrition services. Some strategies adopted possible because temporary or emergency flexibilities policies. We present examples primarily from our outpatient practices, with efforts by public health inpatient acknowledged. hope...
Abstract Cryptococcus neoformans is an encapsulated pathogenic fungus, which primarily infects immunocompromised individuals including HIV-infected patients, organ transplant recipients, and patients treated with immunosuppressive drugs. Each year, about 180,000 people die from cryptococcosis. Although it believed that C. enters the body through airway initially causes infections in lung, cryptococcosis commonly presents as meningoencephalitis. Previous studies mainly focused on immune...
Abstract Cryptococcus neoformans is an opportunistic fungal pathogen, and a leading cause of death among HIV-infected individuals. These encapsulated yeast fungi are believed to enter the body through respiratory tract initially pulmonary infection. If host immune system fails contain cells within lung, organism will disseminate brain via bloodstream, consequently resulting in fatal meningoencephalitis. As such, early interactions between C. lung critical for determining progression disease....
Abstract Monocytes exist in two major populations, termed Ly6Chi and Ly6Clow monocytes. Compared to monocytes, less is known about monocyte recruitment mechanisms involved the of this subset. Furthermore, role monocytes during infections largely unknown. Here, using intravital microscopy, we demonstrate that are predominantly recruited brain vasculature following infection with Cryptococcus neoformans, a fungal pathogen causing meningoencephalitis. The depends primarily on interaction VCAM1...
Abstract Cryptococcus neoformans is a pathogenic fungus accounting for 180,000 deaths worldwide per year. The infection starts in the lung; however, can migrate to brain, causing fatal meningoencephalitis primarily immunocompromised individuals. TNF-α has been shown mediate protective immunity lung during pulmonary with C. neoformans. However, functions of signaling brain remain poorly understood. Recent studies have that CD4+ T cells and inflammatory monocytes (IMs) cryptococcal clearance...
Abstract Aspergillus fumigatus is an opportunistic fungal pathogen that causes a wide spectrum of diseases in humans, including life-threatening invasive infections as well number hypersensitivity respiratory disorders. Disease prevention predicated on the host’s ability to clear A. from lungs while also limiting inflammation and preventing allergic responses. IL-27 important immunoregulatory cytokine, but its role during infection remains poorly understood. In contrast most settings showing...