A5048878995- Sleep and related disorders
- Sleep and Wakefulness Research
- Sleep and Work-Related Fatigue
- Cognitive Functions and Memory
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Cognitive Abilities and Testing
- Circadian rhythm and melatonin
- Workplace Health and Well-being
- Attention Deficit Hyperactivity Disorder
- Decision-Making and Behavioral Economics
- Genetics and Neurodevelopmental Disorders
- Retirement, Disability, and Employment
- Cardiovascular Function and Risk Factors
- Perfectionism, Procrastination, Anxiety Studies
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Psychosomatic Disorders and Their Treatments
- Technology Use by Older Adults
- Family and Disability Support Research
- Non-Invasive Vital Sign Monitoring
- Healthcare professionals’ stress and burnout
- Hospital Admissions and Outcomes
National University of Singapore
2014-2025
Yong In University
2022
Duke-NUS Medical School
2015-2021
National Neuroscience Institute
2019
To investigate the effects of sleep restriction (7 nights 5 h time in bed [TIB]) on cognitive performance, subjective sleepiness, and mood adolescents. A parallel-group design was adopted Need for Sleep Study. Fifty-six healthy adolescents (25 males, age = 15–19 y) who studied top high schools were not habitual short sleepers randomly assigned to Restriction (SR) or Control groups. Participants underwent a 2-w protocol consisting 3 baseline (TIB 9 h), 7 opportunity manipulation SR control...
Wearable devices have tremendous potential for large-scale longitudinal measurement of sleep, but their accuracy needs to be validated. We compared the performance multisensor Oura ring (Oura Health Oy, Oulu, Finland) polysomnography (PSG) and a research actigraph in healthy adolescents.Fifty-three adolescents (28 females; aged 15-19 years) underwent overnight PSG monitoring while wearing both an Actiwatch 2 (Philips Respironics, USA). Measurements were made over multiple nights across three...
Retrieving false information can have serious consequences. Sleep is important for memory, but voluntary sleep curtailment becoming more rampant. Here, the misinformation paradigm was used to investigate memory formation after 1 night of total deprivation in healthy young adults (N = 58, mean age ± SD 22.10 1.60 years; 29 males), and 7 nights partial (5 h opportunity) these adolescents 54, 16.67 1.03 25 males). In both groups, sleep-deprived individuals were likely than well-rested persons...
Although East Asia harbors the largest number of aging adults in world, there is currently little data clarifying longitudinal brain-cognition relationships this group. Here, we report structural MRI and neuropsychological findings from relatively healthy Chinese older Singapore-Longitudinal Aging Brain Study cohort over 8 years follow up (n=111, mean age=67.1 years, range=56.1-83.1 at baseline). Aging-related change volume was observed, with total cerebral atrophy -0.56%/year, hippocampal...
Anxiety is common in autism spectrum disorder. Many anxiety symptoms disorder are consistent with Diagnostic and Statistical Manual of Mental Disorders (5th ed.) disorders (termed "common" anxieties), but others may be qualitatively different, likely relating to traits (herein termed "autism-related" anxieties). To date, few studies have examined both experiences We explored caregiver-reported Spence Children's Scale-Parent version data from a multi-site (United Kingdom, Singapore, United...
Abstract Study Objectives To determine how mid-afternoon naps of differing durations benefit memory encoding, vigilance, speed processing (SOP), mood, and sleepiness; to evaluate if these benefits extend past 3 hr post-awakening examine sleep macrostructure during modulate benefits. Methods Following short habitual sleep, 32 young adults underwent four experimental conditions in randomized order: wake; 10 min, 30 60 min duration verified with polysomnography. A 10-min test battery was...
To evaluate the benefits of applying an improved sleep detection and staging algorithm on minimally processed multi-sensor wearable data collected from older generation hardware.58 healthy, East Asian adults aged 23-69 years (M = 37.10, SD 13.03, 32 males), each underwent 3 nights PSG at home, wearing 2nd Generation Oura Rings equipped with additional memory to store raw accelerometer, infra-red photoplethysmography temperature sensors. 2-stage 4-stage classifications using a new...
Human sleep schedules vary widely across countries. We investigated whether these variations were related to differences in social factors, Morningness-Eveningness (ME) preference, or the natural light-dark cycle by contrasting duration and timing of young adults (age: 18-35 years) on work free days Singapore (n = 1898) UK 837). On days, people had later bedtimes, but wake times similar sample, resulting shorter duration. In contrast, did not differ between two Shorter without compensatory...
Objective It is common for individuals to engage in taxing cognitive activity prolonged periods of time, resulting fatigue that has the potential produce significant effects behaviour and decision making. We sought examine whether modulates economic Methods employed a between-subject manipulation design, inducing through 60 90 minutes engagement against control group watched relaxing videos matched period time. Both before after manipulation, participants engaged two making tasks (one gains...
Abstract Daytime naps have been linked with enhanced memory encoding and consolidation. It remains unclear how a daily napping schedule impacts learning throughout the day, whether these effects are same for well-rested sleep restricted individuals. We compared in 112 adolescents who underwent two simulated school weeks containing 8 or 6.5 h opportunities each day. Sleep episodes were nocturnal split between 90-min afternoon nap, creating four experimental groups: h-continuous, h-split,...
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link health outcomes like cognition. However, there remains lack of studies investigating the rate brain relationship Furthermore, most models are trained tested on cross-sectional data from primarily Caucasian, adult participants. It is thus unclear how well these generalize non-Caucasian participants, especially children. Here, we previously published deep learning model Singaporean elderly participants...
Abstract Study Objectives We compared the basic cognitive functions of adolescents undergoing split (nocturnal sleep + daytime nap) and continuous nocturnal schedules when total opportunity was either below or within recommended range (i.e. 6.5 8 h). Methods Adolescent participants (age: 15–19 year) in 8-h (n = 24) 29) groups were with 6.5-h from a previous study 58). These protocols involved two baseline nights (9-h time-in-bed [TIB]), 5 manipulation, 2 recovery TIB), followed by second...
Abstract Study Objectives Afternoon naps benefit memory but this may depend on whether one is a habitual napper (HN; ≥1 nap/week) or non-habitual (NN). Here, we investigated nap would HN and NN differently, as well be more adversely affected by restriction compared to NN. Methods Forty-six participants in the condition (HN-nap: n = 25, NN-nap: 21) took 90-min (14:00–15:30 pm) experimental days while 46 Wake (HN-wake: 24, NN-wake: 22) remained awake afternoon. Memory tasks were administered...
Left atrial (LA) dysfunction has been linked to cognitive impairment and cerebrovascular dysfunction. Higher brain free-water (FW) derived from diffusion-MRI was associated with early subtle more severe impairment. We hypothesized that LA would correlate higher among healthy older adults. 56 community adults (73.13 ± 3.56 years; 24 female) normal cognition without known cardiovascular disease who had undergone cardiac-MRI, brain-MRI, neuropsychological assessments were included. Whole-brain...
Abstract Study Objectives Previous studies examining bidirectional relationships between nocturnal sleep and napping have focused on duration, leaving a gap in our understanding of how timing contributes. Here, we assessed the duration for night daytime naps, to evaluate previous night’s influences next day's napping, same-night sleep. Methods We analyzed diary actigraphy data from 153 teens (males = 43.8%, mean age 16.6 years). Participants who never napped were excluded. Nocturnal...
Previous studies have shown that sleep benefits prospective memory by facilitating spontaneous retrieval processes. Here, we investigated the features supporting such a benefit. Forty-nine young adults (mean age ± SD: 22.06 1.71 years; 18 males) encoded intentions comprising four related (phone-unplug earphones) and unrelated (mirror-close book) cue–action pairs. They were instructed to remember perform these actions in response cue words presented during semantic categorization task 12 h...
Existing literature suggests that sleep-dependent memory consolidation is impaired in older adults but may be preserved for personally relevant information. Prospective (PM) involves remembering to execute future intentions a timely manner and has behavioral importance. As previous work N3 sleep important PM young adults, we investigated if the role of would maintained adults. Forty-nine (mean age ± SD: 21.8 1.61 years) 49 healthy 65.7 6.30 were randomized into wake groups. After semantic...
Age-related cognitive deficits may be diminished by tapping into prior knowledge structures. We investigated age-related differences in the formation and updating of schemas examined whether memory benefits recently acquired would preserved older adults. Data were collected from 60 adults (