A5079673030- Immune Response and Inflammation
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Influenza Virus Research Studies
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Adipokines, Inflammation, and Metabolic Diseases
- interferon and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Corneal Surgery and Treatments
- Infectious Encephalopathies and Encephalitis
- Synthesis and biological activity
- Respiratory viral infections research
- Hip and Femur Fractures
- Morinda citrifolia extract uses
- Cell death mechanisms and regulation
- Veterinary medicine and infectious diseases
- Signaling Pathways in Disease
- Genomics, phytochemicals, and oxidative stress
- Bioactive natural compounds
- Mast cells and histamine
- Galectins and Cancer Biology
- Bone fractures and treatments
- Essential Oils and Antimicrobial Activity
Fox Chase Cancer Center
2024
Hallym University
2019-2023
Research Institute for Bioscience and Biotechnology
2019
Korea Research Institute of Bioscience and Biotechnology
2019
Yonsei University
2011-2014
Other SectionsAbstractINTRODUCTIONFUNCTIONAL DIVERSITY OF MACROPHAGESIMMUNOMETABOLISM MACROPHAGESMETABOLIC DISEASES AND MACROPHAGESCONCLUDING REMARKSACKNOWLEDGEMENTSCONFLICTS INTERESTFiguresTableReferences
Purpose: Profibrotic activation is essential for pterygium development. In this study, we investigated the role of mechanistic target rapamycin (mTOR) in regulating TGF-β1-induced myofibroblastic responses human fibroblasts (HPFs) and elucidated relative contributions mTOR signaling components. Methods: HPFs were pretreated with inhibitors Torin2, expression profibrotic markers, including α-smooth muscle actin (α-SMA) fibronectin, was evaluated. RNA interference-based approaches targeting...
Macrophages are important for the first line of defense against microbial pathogens. Integrin CD11b, which is encoded by Itgam, expressed on surface macrophages and has been implicated in adhesion, migration, cell-mediated cytotoxicity. However, functional impact CD11b inflammatory responses upon infection remains unclear. Here, we show that deficiency resulted increased susceptibility to sepsis induced methicillin-resistant Staphylococcus aureus (MRSA) enhancing pro-inflammatory activities...
The herbal plant Angelica gigas (A. gigas) has been used in traditional medicine East Asian countries, and its chemical components are reported to have many pharmacological effects. In this study, we showed that a bioactive ingredient of A. modulates the functional activity macrophages investigated effect on inflammation using sepsis model. Among 12 different compounds derived from gigas, decursinol angelate (DA) was identified as most effective suppressing induction TNF-α IL-6 murine...
Influenza is a major cause of highly contagious respiratory illness resulting in high mortality and morbidity worldwide. Annual vaccination an effective way to prevent infection complication from constantly mutating influenza strains. Vaccination utilizes preemptive inoculation with live virus, attenuated inactivated or virus segments for optimal immune activation. The route administration also affects the efficacy vaccination. Here, we evaluated effects ultraviolet (UV)-inactivated A...
Toll-like receptors (TLRs) have a crucial role not only in triggering innate responses against microbes but orchestrating an appropriate adaptive immunity. However, deregulated activation of TLR signaling leads to chronic inflammatory conditions such as bowel disease (IBD). In this study, we evaluated the immunomodulatory potential inhibitor form cell-penetrating peptide using ulcerative colitis animal model. A derived from TIR domain adaptor molecule TIRAP that was conjugated with sequence...
Angelica gigas has been used as a Korean traditional medicine for pain relief and gynecological health. Although the extracts are reported to have an anti-inflammatory property, bioactive compounds of herbal plant effect on T cell responses unclear. In this study, we identified decursinol angelate (DA) immunomodulatory ingredient A. demonstrated its suppressive type 17 helper (Th17) responses. Helper culture experiments revealed that DA impeded differentiation Th17 cells IL-17 production...
In humans, respiratory infections with influenza A viruses can be lethal, but it is unclear whether non-respiratory equally lethal. Intraperitoneal infection makes the abdominal and pelvic organs accessible to pathogens because of circulation peritoneal fluid throughout pelvis abdomen. We found that high-dose intraperitoneal in mice resulted severe sclerosis structural damage pancreas, disruption ovarian follicles, massive infiltration immune cells uterus. The also caused robust upregulation...