A5071008040- Cytokine Signaling Pathways and Interactions
- Cystic Fibrosis Research Advances
- Advanced biosensing and bioanalysis techniques
- Macrophage Migration Inhibitory Factor
- Protein Tyrosine Phosphatases
- Neonatal Respiratory Health Research
- Fungal Biology and Applications
- Enzyme Production and Characterization
- Phytochemical compounds biological activities
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Mechanisms and Therapy
Galapagos (Belgium)
2024
Research Triangle Park Foundation
2012
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) protein. This epithelial anion channel regulates active transport of chloride and bicarbonate ions across membranes. Mutations result reduced surface expression CFTR channels with impaired functionality. Correctors are small molecules that support trafficking to increase its membrane expression. Such correctors can have different mechanisms action. Combinations may a further improved therapeutic...
Tyrosine kinase 2 (TYK2) mediates cytokine signaling through type 1 interferon, interleukin (IL)-12/IL-23, and the IL-10 family. There appears to be an association between TYK2 genetic variants inflammatory conditions, clinical evidence suggests that selective inhibition of could produce a unique therapeutic profile. Here, we describe discovery compound