A5012502548- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Child and Adolescent Psychosocial and Emotional Development
- Congenital Anomalies and Fetal Surgery
- Muscle Physiology and Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Child Abuse and Trauma
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Smoking Behavior and Cessation
- Energy Harvesting in Wireless Networks
- Resilience and Mental Health
- Tumors and Oncological Cases
- Lung Cancer Research Studies
- Schizophrenia research and treatment
- Early Childhood Education and Development
- Adolescent and Pediatric Healthcare
- RNA Research and Splicing
- Family Support in Illness
- Mental Health Treatment and Access
- Prenatal Substance Exposure Effects
- Birth, Development, and Health
- Substance Abuse Treatment and Outcomes
- Family and Disability Support Research
- Cardiac Structural Anomalies and Repair
Biogen (United States)
2018-2024
Brown University
2011-2017
Harvard University
2010-2011
Simmons University
2000-2010
McLean Hospital
2009
Boston Children's Hospital
2009
Hospital Comarcal de Inca
2001
Abstract Introduction/Aims NURTURE (NCT02386553) is an open‐label study of nusinersen in children (two SMN2 copies, n = 15; three 10) who initiated treatment the presymptomatic stage spinal muscular atrophy (SMA). A prior analysis after ~3 y showed benefits on survival, respiratory outcomes, motor milestone achievement, and a favorable safety profile. An additional 2 follow‐up (data cut: February 15, 2021) are reported. Methods The primary endpoint time to death or intervention (≥6 h/day...
OBJECTIVE: The identification of predictors major depression in the transition to adulthood has direct application prevention and intervention efforts designed forestall this high-risk period. current study identified childhood adolescent familial behavioral-emotional factors predicting during critical developmental stage. METHOD: 354 participants were part a single-age cohort from predominately Caucasian working-class community whose psychosocial development been traced prospectively since...
A study of 384 18-year-old adolescents living in the community demonstrated a frequent co-occurrence substance use disorders and post-traumatic stress disorder. Multiple pathways appeared to lead this comorbidity, which was associated with widespread psychological impairment that might have serious developmental consequences. Implications for research practice are discussed.
ABSTRACT Aims Problem gambling can create major financial, emotional and sometimes criminal problems for an individual. This study prospectively investigated the association between impulsive behavior at age 7 development of life‐time problem by adulthood. We also examined specificity any observed behaviors conducting parallel analyses examining link respondents' shy/depressed in childhood later gambling. Design, setting participants Cohort 958 offspring mothers enrolled Collaborative...
BACKGROUND: Although long-held wisdom and current research suggests that accepting supportive family relationships may positively influence adult psychosocial functioning, few studies have prospectively investigated these associations. This study examined whether positive factors during adolescence are associated with healthy functioning. METHOD: The 353 participants were part of a single-age cohort whose development has been traced. Two aspects functioning - feeling highly valued as member...
This study examined the association between active and past major depression deficits in young adult functioning using data from a longitudinal community (N = 354). Three groups were compared: (1) participants with 1-year diagnosis of at age 26 (active group); (2) those who experienced during transition to adulthood, ages 18–25, but did not have (past (3) individuals meeting diagnostic criteria for period. Results highlight serious psychosocial linked both depression. Although greatest...
Nusinersen clinical trials have limited data on adolescents and adults with 5q-associated spinal muscular atrophy (SMA). We conducted a systematic literature review (SLR) meta-analysis to assess effectiveness of nusinersen in SMA practice.
Background Although many observational studies have found a strong association between maternal smoking during pregnancy (MSP) and offspring antisocial behaviour, the likelihood that this relationship is causal remains unclear. To comment on potential causality of association, current investigation used between–within decomposition approach to examine MSP multiple indices adolescent adult behaviour. Methods Study participants were women enrolled in Providence Boston sites Collaborative...
<h3>Background</h3> Although a number of previous studies have reported an association between maternal smoking during pregnancy (MSP) and externalising behaviour problems among offspring, it has been suggested that this relationship is spurious due to the failure these properly account for important confounding factors. <h3>Methods</h3> The MSP adult criminal offending was examined using data from 3766 members Providence, Rhode Island, cohort Collaborative Perinatal Project. Information on...
Background Persistent engagement in antisocial behaviour across developmental periods is thought to increase the risk for early disease morbidity. However, less known about potential adverse health outcomes among much larger subset of individuals with limited adolescence. Methods Using data from Providence, Rhode Island cohort Collaborative Perinatal Project, we examined association between developmentally based subtypes and (n=801). Official arrest records self-reports were used classify...
Background: Cure SMA maintains the largest patient-reported database for people affected with spinal muscular atrophy (SMA). In 2017, initiated annual surveys their membership to collect demographic and disease characteristics, healthcare, burden of information from patients caregivers. Objective: To summarize results two large-scale in 2017 2018. Methods: members were invited complete surveys; these completed by caregivers living or deceased individuals and/or adults. Results: 726 695 SMA;...
Spinal muscular atrophy (SMA) is a rare neuromuscular disease characterized by progressive and weakness. Nusinersen was the first treatment approved for SMA. Per US label, nusinersen administration schedule consists of three loading doses at 14-day intervals, fourth dose 30 days later, maintenance every 4 months thereafter. Using two large databases, we evaluated real-world adherence to with its unique dosing among generalizable populations patients Patients SMA treated nusinersen, likely...
Abstract Objective This study investigated early predictors for developing eating disorders by young adulthood in a community sample of women participating 22‐year longitudinal study. Method Twenty‐one were identified at age 27 with lifetime full or partial disorders. These compared 47 no history on predictive factors from three broad domains. Results The had more serious health problems before 5 and mother‐reported anxiety‐depression 9. At 15, mothers described them as having behavior...