A5014057966- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
European Institute of Oncology
2021-2023
CD8+ T cells are a major prognostic determinant in solid tumors, including colorectal cancer (CRC). However, understanding how the interplay between different immune impacts on clinical outcome is still its infancy. Here, we describe that interaction of tumor infiltrating neutrophils expressing high levels CD15 with effector memory (TEM) correlates progression. Mechanistically, stromal cell-derived factor-1 (CXCL12/SDF-1) promotes retention within increasing crosstalk cells. As consequence...
Abstract Background The association between microbes and cancer has been reported repeatedly; however, it is not clear if molecular tumour properties are connected to specific microbial colonisation patterns. This due mainly the current technical analytical strategy limitations characterise tumour-associated bacteria. Methods Here, we propose an approach detect bacterial signals in human RNA sequencing data associate them with clinical of tumours. method was tested on public datasets from...
Abstract Background. A comprehensive understanding of the role immune reactions in progression early-stage colorectal cancer (CRC) is currently lacking. Tumor infiltration by cytotoxic CD8+ T cells has been associated with a better prognosis several solid tumors, including CRC, and high levels memory prevent early metastatic invasion are survival. However, tumor infiltrate highly heterogeneous and, although influence various myeloid cell populations on activity reported, our interplay...
ABSTRACT Tumor contexture has emerged as a major prognostic determinant and tumor infiltrating CD8 + T cells have been associated with better prognosis in several solid tumors, including early-stage colorectal cancer (CRC). However, the immune infiltrate is highly heterogeneous understanding how interplay between different cell compartments impacts on clinical outcome still its infancy. Here, we describe prospective cohort novel effector memory population, which characterized by high levels...