A5073005842- Lipid Membrane Structure and Behavior
- Carbohydrate Chemistry and Synthesis
- Pancreatic function and diabetes
- Sphingolipid Metabolism and Signaling
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Enzyme Catalysis and Immobilization
- Pain Mechanisms and Treatments
- Porphyrin and Phthalocyanine Chemistry
- Biochemical and Molecular Research
- Biomedical Research and Pathophysiology
- Glycosylation and Glycoproteins Research
- Photodynamic Therapy Research Studies
- Optical Systems and Laser Technology
- Laser-Plasma Interactions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Analytical Chemistry and Chromatography
- Laser-induced spectroscopy and plasma
- Immune cells in cancer
- Pancreatitis Pathology and Treatment
- Cancer therapeutics and mechanisms
- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Biochemical Analysis and Sensing Techniques
- Pharmacogenetics and Drug Metabolism
Gunma University
2018-2023
Secretory proteins and lipids are biosynthesized in the endoplasmic reticulum (ER). The "protein quality control" system (PQC) monitors glycoprotein folding supports elimination of terminally misfolded polypeptides. A key component PQC is Uridine diphosphate glucose:glycoprotein glucosyltransferase 1 (UGGT1). UGGT1 re-glucosylates unfolded glycoproteins, to enable re-entry protein-folding cycle impede aggregation glycoproteins. In contrast, a complementary "lipid (LQC) that maintains lipid...
Atherosclerosis is a major cause of cerebral and cardiovascular diseases. Intravascular plaques, well-known pathological finding atherosclerosis, have necrotic core composed macrophages dead cells. Intraplaque macrophages, which are classified into various subtypes, play key roles in maintenance normal cellular microenvironment. Excessive uptake oxidized low-density lipoprotein causes conversion to foam cells, consequent progression/exacerbation atherosclerosis. G-protein-coupled receptor 55...
G protein-coupled receptor 55 (GPR55) is highly expressed in brain and peripheral nervous system. Originally deorphanized as a cannabinoid receptor, recently GPR55 has been described lysophospholipid-responsive specifically toward lysophosphatidylinositol lysophosphatidyl-β-d-glucoside (LysoPtdGlc). To characterize lysolipid-GPR55 interaction, synthetic access to LysoPtdGlc selected analogues was established utilizing phosphorus(III)-based chemical approach. The biological activity of each...
The glycosylation of unprotected carbohydrates has emerged as an area significant interest because it obviates the need for long reaction sequences involving protecting-group manipulations. Herein, we report one-pot synthesis anomeric glycosyl phosphates through condensation with phospholipid derivatives while retaining high stereo- and regioselective control. center was activated using 2-chloro-1,3-dimethylimidazolinium chloride to facilitate glycerol-3-phosphate in aqueous solution. A...
Abstract Lyso ‐phosphatidyl β‐D‐glucoside (lysoPtdGlc) is during embryonic development a neurite growth cone guidance cue associated with G‐protein coupled receptor 55, and has been found to be involved in variety of physiological pathological events, including inflammatory pain, cancer. Hence, the ability prepare large quantities lysoPtdGlc an important objective. Herein, we report convergent chemical synthesis its glyceryl epimer ( S ‐lysoPtdGlc). High stereocontrol β‐glycosyl H...
We synthesized a new silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-D-glucopyranose (SGlc). Conjugation SGlc improved A549 cellular uptake without significant changes in the photophysical and photochemical properties subcellular localization. This led to enhanced photodynamic activity. Furthermore, conjugation suppressed dark toxicity. These advantages were not observed for conjugate glucose molecule. results indicated that is promising strategy enhancing efficacy.