A5081770104- Energy Load and Power Forecasting
- Climate variability and models
- DNA and Nucleic Acid Chemistry
- Atmospheric and Environmental Gas Dynamics
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
Technical University of Denmark
2023
University of Copenhagen
2009
While sequence-selective dsDNA targeting by triplex forming oligonucleotides has been studied extensively, only very little is known about the properties of PNA–dsDNA triplexes—mainly due to competing invasion process. Here we show that when appropriately modified using pseudoisocytosine substitution, in combination with (oligo)lysine or 9-aminoacridine conjugation, homopyrimidine PNA oligomers bind complementary targets via formation (sub)nanomolar affinities (at pH 7.2, 150 mM Na+)....
Summary We consider reconciliation of wind power forecasts in a spatial hierarchy with three aggregation levels. produce base for the bottom level consisting 407 substations (connection points local groups turbines). State‐of‐the‐art from commercial forecast provider are available middle and top levels, which consist 15 regions entire Western Denmark (DK1), respectively. find that accuracy total can be improved through reconciliation, even relatively simple model used at lowest hierarchy....