A5033120496- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Calpain Protease Function and Regulation
- Alzheimer's disease research and treatments
- Cell death mechanisms and regulation
Achucarro Basque Center for Neuroscience
2020-2023
University of the Basque Country
2020-2021
In neurons, like in any other cell, their function often relies on the fine tuning of protein levels, which is achieved by balance between synthesis and turnover. Defects homeostasis frequently leads to neuronal dysfunction neurological disorders. Given extreme morphological complexity high compartmentalization, neurons highly depend asymmetrical distribution proteome. The common belief that proteins sustain axonal, dendritic synaptic functions are synthesized soma then transported distal...
Subcellular protein delivery is especially important in signal transduction and cell behavior, typically achieved by localization signals within the protein. However, can also rely on of mRNAs that are translated at target sites. Although once considered heretical, RNA has proven to be highly conserved eukaryotes. localized translation relevant polarized cells like neurons where neurites extend dozens hundreds centimeters away from soma. Local confers dendrites axons capacity respond their...
Altered expression of microRNAs (miRNAs) after spinal cord injury (SCI) has been described as being responsible for the main secondary responses, such apoptosis. X-linked inhibitor apoptosis protein (XIAP) is a key apoptotic component involved in progression programmed cell death. Several regulators have to modulate XIAP's function, including post-transcriptional regulator's miRNAs. The aim present work identify miRNAs with altered SCI which can regulate XIAP expression. Our bioinformatic...
Altered expression of microRNAs (miRNAs) after spinal cord injury (SCI) has been described as being responsible for the main secondary responses, such apoptosis. X-linked inhibitor apoptosis protein (XIAP) is a key apoptotic component involved in progression programmed cell death. Several regulators have to modulate XIAP's function, including post-transcriptional regulator's miRNAs. The aim present work identify miRNAs with altered SCI which can regulate XIAP using bioinformatics and...
Abstract Subcellular protein delivery is especially important in signal transduction and cell behavior, typically achieved by localization signals within the protein. However, can also rely on of mRNAs that are translated at target sites. Although once considered heretical, RNA has proven to be highly conserved eukaryotes. localized translation relevant polarized cells like neurons where neurites extend dozens hundreds centimeters away from soma. Local confers dendrites axons capacity...
Abstract Background Under pathological conditions axons respond to Aβ oligomers by increasing localized translation which in turn contributes neurodegeneration. Additionally, a link between intra‐dendritic translation, and Tau mislocalization hyperphosphorilation has been found. Thus, dysregulation of local protein synthesis neurons seems play relevant role AD. Although recently become accepted, there are several aspects this phenomenon that still under debate. It is unclear whether fully...