Lay Kim Tan

ORCID: 0000-0001-5846-2783
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About
Contact & Profiles
Research Areas
  • Maternal and fetal healthcare
  • Rheumatoid Arthritis Research and Therapies
  • Obesity, Physical Activity, Diet
  • Systemic Lupus Erythematosus Research
  • Neuroscience of respiration and sleep
  • Pregnancy and preeclampsia studies
  • Nutritional Studies and Diet
  • Ectopic Pregnancy Diagnosis and Management
  • T-cell and B-cell Immunology
  • Spondyloarthritis Studies and Treatments
  • Breast Cancer Treatment Studies
  • Immune Cell Function and Interaction
  • Monoclonal and Polyclonal Antibodies Research
  • Pregnancy and Medication Impact
  • Psoriasis: Treatment and Pathogenesis
  • Gastroesophageal reflux and treatments
  • Endometriosis Research and Treatment
  • Cancer Treatment and Pharmacology
  • Mosquito-borne diseases and control
  • Pediatric Pain Management Techniques
  • Gestational Trophoblastic Disease Studies
  • Health and Wellbeing Research
  • Viral Infections and Vectors
  • Liver Disease Diagnosis and Treatment
  • Infant Health and Development

Ministry of Health
2018-2025

National University Health System
2024

National University Hospital
2024

National Institutes of Biotechnology Malaysia
2024

Northern University of Malaysia
2023

Institute for Medical Research
2016-2022

A*STAR-NUS Clinical Imaging Research Centre
2022

KK Women's and Children's Hospital
2022

University of Kuala Lumpur
2018-2021

Memorial Sloan Kettering Cancer Center
2004-2019

The role of ventral respiratory group (VRG) expiratory (E) neurons in the control abdominal and internal intercostal (expiratory) muscle activity during vomiting was examined decerebrate cats by recording from these fictive paralyzed animals comparing before after sectioning axons descending neurons. Fictive defined a series bursts coactivation phrenic nerves elicited either subdiaphragmatic vagus nerve stimulation or emetic drugs. Such coordinated would be expected to produce if were not...

10.1152/jn.1987.57.6.1854 article EN Journal of Neurophysiology 1987-06-01

Background: Sedentary behaviors (SBs), which are low-energy, wakeful activities performed in a sitting, reclining, or lying posture, independently associated with numerous adverse health outcomes, including mental disorders, non-communicable diseases, and an increased risk of mortality. This study investigated associations between sociodemographic characteristics, lifestyle factors, health, nutritional status, social support, functional limitations, SB among older persons Malaysia. Methods:...

10.3390/healthcare13020160 article EN Healthcare 2025-01-15

Background/objective: We examined the prevalence of daily SSB intake, identifying its sociodemographic determinants, and exploring potential association with undiagnosed non-communicable diseases (NCDs) among Malaysian adults. Methods: This cross-sectional study analyzed data from 6,596 adults participating in 2019 National Health Morbidity Survey (NHMS). Multiple logistic regression was used to examine between intake risk diabetes, hypertension, hypercholesterolemia, obesity, while...

10.20944/preprints202503.1478.v1 preprint EN 2025-03-20

ABSTRACT This study examines the influences of demographic, lifestyle and environmental factors on sleep loneliness problems (SLP) among adolescents in Malaysia. SLP was formed based magnitudes adolescent deprivation loneliness. Its scores were derived from five responses to two questions related The minimum maximum 0 8, respectively. Data obtained cross‐sectional surveys. Lognormal hurdle models utilized. Females, high grade levels having divorced/widowed parents associated with severe SLP....

10.1002/pits.23524 article EN Psychology in the Schools 2025-04-20

This study aimed to report the prevalence of obesity, classified using Asian cut-off, and its relationships with undiagnosed diabetes mellitus, high blood pressure, hypercholesteremia. We analyzed nationally representative data from 14,025 Malaysian adults who participated in NHMS 2015. The relationship between obesity hypercholesteremia was determined multivariable logistic regressions, lifestyle risk factors sociodemographic characteristics were adjusted. pressure group showed highest...

10.3390/ijerph20043058 article EN International Journal of Environmental Research and Public Health 2023-02-09

1. The role of dorsal and ventral respiratory group (DRG VRG) bulbospinal inspiratory (I) neurons in the control diaphragmatic external intercostal (inspiratory) muscle activity during vomiting was examined by recording from these fictive decerebrate, paralyzed cats. Fictive defined a characteristic series bursts coactivation phrenic abdominal nerves, elicited either electrical stimulation vagal afferents or emetic drugs, which would be expected to produce if animals were not paralyzed. 2....

10.1152/jn.1990.63.1.31 article EN Journal of Neurophysiology 1990-01-01

The pathology of four types chondrodysplasias, viz., type II achondrogenesis, thanatophoric dwarfism, Saldino-Noonan syndrome, and chondrodysplasia punctata were studied. In each these disorders, cells with features similar to the chief dark chondrocytes normal hyaline cartilage seen be altered in different ways. There was a total absence achondrogenesis. All present one variety at states maturation, fully matured cell having chondrocytes. associated marked diminution interlacunar matrix...

10.1002/path.1711270103 article EN The Journal of Pathology 1979-01-01

Abstract Background Fine-mapping of human leukocyte antigen ( HLA ) region for rheumatoid arthritis (RA) risk factors has identified several alleles and its corresponding amino acid residues as independent signals (i.e., HLA-A , HLA-B HLA-DPB1 HLA-DQA1 genes), in addition to the well-established genetic factor HLA-DRB1 gene. However, this was mainly performed Caucasian East Asian populations, data from different regions is less represented. We aimed evaluate whether there are RA variants...

10.1186/s13075-021-02431-z article EN cc-by Arthritis Research & Therapy 2021-01-30

SLE is a heterogeneous autoimmune disease, in terms of clinical presentation, incidence and severity across diverse ethnic populations. We investigated the human leucocyte antigens (HLA) profile (ie, HLA-A, HLA-B HLA-C, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1 HLA-DPB1) Malaysian Malay female patients with determined generalisability published HLA risk factors different populations globally including Malaysia. One hundred were recruited between January 2016 October 2017 from nephrology clinic....

10.1136/lupus-2021-000554 article EN cc-by-nc Lupus Science & Medicine 2022-02-01

<i>Objective:</i> To evaluate whether a test amnioinfusion procedure is useful in selecting cases of midtrimester preterm premature rupture membranes (PPROM) which may benefit from serial amnioinfusions if the initial fluid retained. <i>Study Design:</i> The Centre for Fetal Care database between 1992 and 2000 was reviewed women with PPROM <26 weeks who had undergone amnioinfusion. Amniotic index (AFI) assessed before after procedure. Those retained ≧48 h underwent...

10.1159/000069375 article EN Fetal Diagnosis and Therapy 2003-01-01

To describe the mammographic and sonographic appearance of a pattern spiculation contour axillary lymph nodes.Eleven cases nodes with spiculated were prospectively identified on routine mammograms. All in women breast cancer. Sonograms available three cases. Medical records reviewed, histologic nodal histopathologic findings patient outcome correlated.All had primary, invasive carcinoma. Although disease was evident mammographically, four nine for whom results physical examination known did...

10.1148/radiology.201.2.8888237 article EN Radiology 1996-11-01

10.1016/s1470-0328(02)01012-1 article EN BJOG An International Journal of Obstetrics & Gynaecology 2002-07-01
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