A5020617181- Regulation of Appetite and Obesity
- Fatty Acid Research and Health
- Hypothalamic control of reproductive hormones
- Biochemical Analysis and Sensing Techniques
- Stress Responses and Cortisol
- Ovarian function and disorders
- Peroxisome Proliferator-Activated Receptors
- Growth Hormone and Insulin-like Growth Factors
- Cholesterol and Lipid Metabolism
- Dietary Effects on Health
- Diet and metabolism studies
- Tryptophan and brain disorders
- Bone Tissue Engineering Materials
- Adenosine and Purinergic Signaling
- Neuroendocrine regulation and behavior
- Orthopaedic implants and arthroplasty
- Pregnancy-related medical research
- Lipid metabolism and biosynthesis
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Eicosanoids and Hypertension Pharmacology
- Dental materials and restorations
- Genomics, phytochemicals, and oxidative stress
- Biochemical effects in animals
- Connexins and lens biology
Medical University of Lodz
2006-2023
National Academy of Sciences India
2019
Czech Academy of Sciences, Institute of Physiology
1990-2006
Pennington Biomedical Research Center
1997-2001
Louisiana State University
1997-2001
The University of Texas Southwestern Medical Center
1998
Tokyo Medical and Dental University
1998
University of New Hampshire
1997
University of New Hampshire at Manchester
1997
A defect in the structure of obese gene is responsible for development obesity ob / mouse. The product expression protein hormone leptin. Leptin causes weight loss and normal mice, it secreted by adipocytes, an important controller size fat stores inhibiting appetite. mouse infertile has a pattern gonadotropin secretion similar to that prepubertal animals. Consequently, we hypothesized leptin might play role control initiated studies on its possible acute effects hypothalamic–pituitary...
Previous experiments have demonstrated that leptin releases luteinizing hormone-releasing hormone (LHRH) from median eminence (ME)-arcuate explants male rats and also stimulates the release of follicle-stimulating (FSH) LH anterior pituitaries with a potency not significantly different LHRH itself. To determine mechanism by which acts at both hypothalamic pituitary level, we evaluated effect competitive inhibitor nitric oxide synthase (NOS), NG-monomethyl-L-arginine (NMMA) on response to...
Previous studies indicated that there is a separate hypothalamic control of follicle-stimulating hormone (FSH) release distinct from luteinizing (LH). An FSH-releasing factor (FSHRF) was purified rat and sheep hypothalami, but has not been isolated. We hypothesized FSHRF might be an analogue mammalian hormone-releasing (m-LHRH) evaluated the activity many analogues m-LHRH known LHRHs found in lower forms. Here we demonstrate lamprey (l) LHRH-III potent, dose-related FSH- LH-releasing action...
Various high‐fat diets are obesogenic but not to the same extent. The aim of present study was investigate effects saturated fat n‐6 and n‐3 polyunsaturated fatty acids (PUFAs) on central neuropeptidergic system in adult rats. Using reverse transcriptase‐polymerase chain reaction situ hybridisation, we evaluated net effect feeding these fats, comparing a high‐ low‐fat diet, diversity fats amount within diet. We also determined plasma lipids, glucose, insulin leptin concentrations. Six‐week...
In humans there is a circadian rhythm of leptin concentrations in plasma with minimum the early morning and maximum middle night. By taking blood samples from adult male rats every 3 hr for 24 hr, we determined that also occurs rat peak at 0130h 0730h. To determine if this controlled by nocturnally released hormones, evaluated effect hormones known to be night humans, some which are rats. prolactin (PRL), growth hormone (GH), melatonin night, adrenocorticotropic (ACTH) release inhibited....
Because ascorbic acid (AA) is concentrated in synaptic vesicles containing glutamic acid, we hypothesized that AA might act as a neurotransmitter. an antioxidant, it therefore inhibit nitric oxidergic (NOergic) activation of luteinizing hormone-releasing hormone (LH-RH) release from medial basal hypothalamic explants by chemically reducing NO. Cell membrane depolarization induced increased potassium concentration [K + ] medium concentrations both and LH-RH. An inhibitor NO synthase (NOS), N...
Somatic symptoms are common in depressive disorder and similar to sickness behaviors due inflammatory activation after cytokine administration. Omega-3 polyunsaturated fatty acids (PUFAs) natural anti-inflammatory agents may reduce inflammation-induced behavioral changes. The aim of this study was investigate the role PUFAs on development somatic depression patients hepatitis C virus infection (HCV) receiving interferon-alpha therapy (IFN-α) a prospective manner.In 24-week, cohort study, 43...
Abstract Background Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to pro-inflammatory cytokines released by activated microglia various neurological pathologies may exacerbate neurodegenerative processes. Accumulating evidence suggests omega-3 docosahexaenoic fatty acid (DHA) has an anti-inflammatory effect cell cultures studies and variety disorders. In this study we examined mechanism involved inhibition DHA...
The aim of our work was to examine the cytotoxicity NiCr alloys coated with Ti(C,N) different amounts C and N in layer on human gingival fibroblasts. Cells were cultured for 24 hours alloy extracts or surface tested materials. viability cells exposed 1-, 3-, 5- 7-day did not change comparison a control medium assayed by an MTT test. Moreover, flow cytometry analysis fibroblasts direct contact revealed that all coatings except TiC induce apoptosis necrosis. Interestingly, hour fibroblast...
Because high concentrations of ascorbic acid (AA) are found in the adenohypophysis, we hypothesized that it might have an acute effect on secretion follicle-stimulating hormone (FSH) and luteinizing (LH) from gland, particularly because reported AA rapidly inhibits stimulated LH-releasing (LHRH) release medial basal hypothalamic explants. Incubation anterior pituitary halves adult male rats with graded for 1 h induced highly significant both FSH LH a minimal effective concentration 10 −5 M....
Abstract. Prior experiments have shown that the adipocyte hormone leptin can advance puberty in mice. We hypothesized it would also stimulate gonadotrophin secretion adults. Since of follicle stimulating (FSH) and luteinizing (LH) is drastically affected by estrogen, we might different actions dependent on dose estrogen. Consequently these experiments, tested effect injection into third cerebral ventricle ovariectomized animals injected with either oil diluent, 10 μg or 50 estradiol benzoate...
The role of immunoproteasome (iP) in astroglia, the cellular component innate immunity, has not been clarified. results so far indicate that neuroinflammation, a prominent hallmark Alzheimer’s disease, strongly activates iP subunits expression. Since omega-3 PUFAs possess anti-inflammatory and pro-resolving activity brain, we investigated effect DHA EPA on gene expression constitutive (β1 β5) inducible (iβ1/LMP2 iβ5/LMP7) proteasome proteasomal IL-1β-stimulated astrocytes. We found both...
Adenosine has been identified in the anterior pituitary gland and is secreted from cultured folliculostellate (FS) cells. To determine whether adenosine controls secretion of hormones vitro, was incubated with pituitaries. It stimulated prolactin (PRL) release at lowest concentration used (10(-10) M); stimulation peaked 10(-8) M a threefold increase declined to minimal 10(-4) 10(-3) M. Follicle-stimulating hormone maximally inhibited M, whereas luteinizing not significantly inhibited. Two...