A5058441664- Organometallic Compounds Synthesis and Characterization
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Crystallography and molecular interactions
- Protease and Inhibitor Mechanisms
- Crystal structures of chemical compounds
Johannes Gutenberg University Mainz
2021-2024
University of Aberdeen
2021
Trypsin-like serine proteases are involved in many important physiological processes like blood coagulation and remodeling of the extracellular matrix. On other hand, they also associated with pathological conditions. The urokinase-pwlasminogen activator (uPA), which is tissue remodeling, can increase metastatic behavior various cancer types when overexpressed dysregulated. Another member this protease class that received attention during SARS-CoV 2 pandemic TMPRSS2. It a transmembrane...
The centrosymmetric title compound, C 22 H 36 N 2 O , was prepared in five steps from diethyl succinate. dipropylamino groups are almost orthogonal to the central phenylenedimethanol ring [dihedral angle = 87.62 (9)°]. In crystal, molecules connected by O—H...N hydrogen bonds, forming (101) layers separated propyl chains.