A5045594092- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Angiogenesis and VEGF in Cancer
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Telomeres, Telomerase, and Senescence
- Meningioma and schwannoma management
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Colorectal Cancer Surgical Treatments
- Digestive system and related health
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Pituitary Gland Disorders and Treatments
Agostino Gemelli University Polyclinic
2021-2024
European Institute of Oncology
2022-2024
University of Milan
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
University of Pisa
2014-2023
Azienda Ospedaliera Universitaria Pisana
2007-2022
Weatherford College
2022
Utrecht University
2016
University Medical Center Utrecht
2016
University Hospital of Bern
2016
The primary aim was to identify radiomics ultrasound features that can distinguish between benign and malignant adnexal masses with solid morphology, (including borderline invasive) metastatic ovarian masses, develop ultrasound-based machine learning models include discriminate masses. secondary compare the discrimination performance of our newly developed Assessment Different NEoplasias in adneXa (ADNEX) model subjective assessment by an experienced examiner. This a retrospective,...
It has been widely demonstrated that neo-angiogenesis and its mediators (i.e. vascular endothelial growth factor), represent useful indicators of poor prognosis in non small cell lung carcinoma. In order to verify whether neovascularization factor may be considered markers clinical outcome also the cancer subgroup, we retrospectively investigated a series 75 patients with carcinoma treated by surgery between 1980 1990. Immunohistochemically-detected microvessels expressing cells were...
Abstract Purpose: The survival rate of non–small cell lung cancer patients is very low, and knowledge predictors outcome inadequate. To improve the curability cancer, we need to identify new specific molecules involved in tumorigenesis progression. purpose this study was better define role osteopontin biology by determining its prognostic significance. Experimental Design: Osteopontin expression evaluated immunohistochemistry, as percentage neoplastic cells with cytoplasmic immunoreactivity,...
Abstract Purpose: The c-kit protein, also known as CD117, is a member of the type III receptor tyrosine kinase family. Kinase activity has been implicated in pathophysiology many tumors, including small-cell lung carcinoma (SCLC). Autocrine or paracrine activation by its ligand postulated for cancer, but this can be activated mutations gene. We examined expression and mutational status SCLC to verify putative genetic alterations, well eventual prognostic impact. Experimental Design: studied...
The vascular endothelial growth factor (VEGF) has been shown to be strictly related permeability and cell under physiological pathological conditions. In tumour development progression, VEGF plays a pivotal role in the of tumoral network, useful information progression human cancer can obtained by analysing expression tumours. this study, we investigated transcript non-small-cell lung carcinomas evaluate significance group cancers which pattern significantly affect progression. Surgical...
Much of the morbidity intracranial meningiomas is related to degree tumour vascularity and extent peritumoural vasogenic oedema. Several studies have shown that vascular endothelial growth factor (VEGF) up‐regulated in meningiomas, although its relationship with vasculature still unclear. In order better understand angiogenic assessment we analysed pattern, both as number morphologic configuration microvessels. Moreover, investigated mRNA‐VEGF expression, relating this expression pattern. A...
Osteopontin (OPN) is a multifunctional protein, which has recently been shown to be linked tumorigenesis, progression and metastasis in different malignancies. Since non-small-cell lung cancer (NSCLC)'s prognosis remains bad, with few predictors of outcome, the purpose this study was evaluate if OPN might involved NSCLC's biology therefore represent prognostic marker target for new therapeutic trials. Immunohistochemistry used detect expression, evaluated as percentage neoplastic cells...
MicroRNAs (miRNAs) play a key role in cancer pathogenesis and are involved several human cancers, including non-small cell lung (NSCLC). This study evaluated Let-7g miR-21 expression by quantitative real-time PCR 80 NSCLC patients correlated the results with their main clinicopathological molecular features. MiR-21 was significantly higher tissues compared to non-cancer (p<0.0001), while no significant changes were observed between tumor normal tissues. Target prediction analysis led...
MiRNAs are vital in functioning as either oncogenes or tumor suppressors the cell cycle. Target transcripts for immune checkpoint molecules such PD-1/PD-L1 and (programmed death-1/its ligand cytotoxic T-lymphocyte antigen 4) have proven to be beneficial against several solid tumors, including lung adenocarcinoma. Simultaneous quantification of expression level miR-33a PD-1, PD-L1 CTLA4 mRNAs with NanoString technology was performed 88 adenocarcinoma specimens. A cohort 323 patients from...
The aim of the present study was to evaluate whether prostate cancer (PC) patients can be accurately classified on bases tissue expression gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA). This retrospective included 28 with PC. Formalin-fixed paraffin-embedded samples were used for diagnosis. Immunohistochemistry staining techniques PSMA GRPR (both number cells expressed % area stained). To assess independent associations among selected variables, a...
Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate levels of inflammation. We have investigated ten single nucleotide (SNPs) following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), PTGS1 (V444I) 377 (CRC) cases 326 controls from Barcelona (Spain).There was no statistically significant association between...
Anaplastic lymphoma kinase (ALK) gene rearrangements are detected in approximately 5% of cases non-small cell lung cancer (NSCLC). Patients who positive for ALK may be successfully treated with the inhibitor crizotinib. Because advanced-stage cancers not suitable surgical resection, 70% patients diagnosed via preoperative specimens. In current study, authors evaluated suitability stained cytologic direct smears and blocks fluorescence situ hybridization (FISH) to determine status compared...
Human telomerase is a structurally complex ribonucleoprotein that responsible for the maintenance of telomeric DNA at ends chromosomes. The enzyme proposed as having an important role in cell immortalization and oncogenesis. A limited number studies have been performed on system brain tumors, these are somewhat conflicting. relative ineffectiveness current therapies malignant gliomas led to need novel targets more promising approaches. In order clarify prognostic significance expression...
Objective: We previously reported the results achieved in detecting sentinel lymph nodes (SLN). applied molecular techniques (RT-PCR) to improve detection of micrometastasis order evaluate an improvement staging early non-small cell lung cancer (NSCLC) patients (pts). Methods: This study was carried out on 22 consecutive NSCLC pts with stage I disease. A dose 37 MBq (1 ml 99mTc-nanocolloid® suspension) administered. The intralesional injection performed under CT-guidance (7 pts), by using...