A5086298494- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Heavy Metal Exposure and Toxicity
- Abdominal Trauma and Injuries
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Immunodeficiency and Autoimmune Disorders
- HVDC Systems and Fault Protection
- Pancreatitis Pathology and Treatment
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Ferroptosis and cancer prognosis
- Trace Elements in Health
- Kruppel-like factors research
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
Xi'an Jiaotong University
2021-2025
Ministry of Education of the People's Republic of China
2025
Institute of Infection and Immunity
2022
Duke University
2020
Abstract Functional CD8 + T cell immunity is essential for immune surveillance and host defense against infection tumors. Epigenetic mechanisms, particularly RNA modification, in controlling response not fully elucidated. Here, by cell-specific deletion of fat mass obesity-associated protein (FTO), a critical N6-methyladenosine (m 6 A) demethylase, we revealed that FTO was indispensable adequate protective function. ablation led to considerable death activated cells, which attributed...
T cells are crucial for adaptive immunity to regulate proper immune response and homeostasis. cell development occurs in the thymus mainly differentiates into CD4
In aged individuals, age-related changes in immune cells, especially T cell deficiency, are associated with an increased incidence of infection, tumor, and autoimmune disease, as well impaired response to vaccination. However, the features gene expression levels cells still unknown. Our previous study successfully tracked generated from one wave developing thymocytes young age by a lineage-specific inducible Cre-controlled reporter ( TCR δ CreER R26 ZsGreen mouse strain). this study, we...
T-cell development in the thymus undergoes process of differentiation, selective proliferation, and survival from CD4-CD8- double negative (DN) stage to CD4+CD8+ positive (DP) prior formation CD4+ helper CD8+ cytolytic T cells ready for circulation. Each developmental is tightly regulated by sequentially operating molecular networks, which only limited numbers transcription regulators have been deciphered. Here, we identified Zfp335 factor as a new player regulatory network controlling...
Abstract The spleen is a vital organ for the immune system, while splenectomy may be necessary various reasons. However, there limited research on impact of T cell function in peripheral lymph nodes as compensatory mechanism preventing infections. This study aimed to investigate characteristics and CD8 + CD4 cells different during viral infection using well‐established model. results revealed that caused an increase GP33 mesenteric (MLN). Moreover, we demonstrated resulted effector KLRG1...
Gastric cancer (GC) is a highly molecular heterogeneous tumor with unfavorable outcomes. The Notch signaling pathway an important regulator of immune cell differentiation and has been associated autoimmune disorders, the development tumors, immunomodulation caused by tumors. In this study, developing gene signature based on genes relevant to pathway, we could improve our ability predict outcome patients GC. From TCGA database, RNA sequencing data GC tumors normal tissues were obtained....
Esophageal carcinoma (ESCA) refers to the most common type of malignant tumor, which reveals that it occurs often all over world. ESCA is also correlated with an advanced stage and low survival rates. Thus, development new prognostic biomarkers absolute necessity. In this study, aim was investigate potential COX7B as a brand-new predictive biomarker for patients. expression in pancancer examined using TIMER2. The statistical significance value explored. relationship between...
The migration is the key step for thymic T cells to enter circulation and then lymph nodes (LNs), essential future immune surveillance. Although promoter-based transcriptional regulation through Foxo1, Klf2, Ccr7, Sell regulates T-cell migration, it remains largely unexplored whether how enhancers are involved in this process. Here we found that conditional deletion of Med1, a component mediator complex between RNA polymerase II, caused reduction both CD4
Thymic regulatory T cells (tTreg) are critical in the maintenance of normal cell immunity and tolerance. The role TCR tTreg selection remains incompletely understood. In this study, we assessed TCRα TCRβ sequences mouse thymic conventional CD4