A5006114498- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Innovative Microfluidic and Catalytic Techniques Innovation
- Click Chemistry and Applications
- Marine Toxins and Detection Methods
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Tannin, Tannase and Anticancer Activities
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Chromatography
Jazan University
2022-2025
University of York
2022
ABSTRACT Various substituted benzothiazole‐thiadiazole‐based ketones 4a‐i and 6a‐c were synthesized characterized by the IR, NMR, MS spectral data. The DFT study of 4 6 displayed matched configurations their HOMO LUMO, with exception nitrophenyl derivatives, whose extended over entire molecule. Meanwhile, antiproliferative effectiveness produced was evaluated against diverse cell lines compared reference drug Erlotinib. exhibited variable inhibitory effects, for example, ketone 6a has most...
ABSTRACT In response to the rising threat of antimicrobial resistance, a novel series thiazole‐based heterocyclic compounds incorporating benzimidazole, benzoxazole, and benzothiazole via reaction 2‐chloro‐N‐(4‐(6‐methyl‐2,4‐dioxo‐3,4‐dihydro‐2H‐pyran‐3‐yl)thiazol‐2‐yl) acetamide (3) with some mercapto derivatives. Pyrazolo[1,5‐ ]pyrimidine motifs were synthesized aminopyrazole derivative 9 electrophilic reagents systematically characterized. The potential these molecules was assessed...
ω-Unsaturated alcohols were "clipped" via alkene metathesis to a thioester activating group, which was followed by chiral phosphoric acid catalyzed intramolecular oxa-Michael cyclization yield tetrahydropyrans and spiro-tetrahydropyrans with excellent enantioselectivity. The mechanism origin of the enantioselectivity probed DFT calculations kinetic isotope studies, where there correlation between computational synthetic investigations.