A5004252411- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Genomics and Phylogenetic Studies
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Antifungal resistance and susceptibility
- Clinical Laboratory Practices and Quality Control
Ethiopian Public Health Institute
2019-2025
Addis Ababa University
2022-2024
Vulvovaginal candidiasis is a global issue of concern due to its association with economic costs, sexually transmitted infections, and ascending genital tract infection. The aim this study was determine species distribution antifungal susceptibility pattern Candida causing vulvovaginal candidiasis. A cross sectional conducted from November 2015 December 2016 at the Family Guidance Association Ethiopia. Vaginal swabs collected subjects that were clinically diagnosed cultured. Yeast...
Bacterial vaginosis is a global concern due to the increased risk of acquisition sexually transmitted infections.To determine prevalence bacterial and bacteria causing aerobic vaginitis.A cross-sectional study was conducted among 210 patients between September 2015 July 2016 at St. Paul's Hospital. Gram-stained vaginal swabs were examined microscopically graded as per Nugent's procedure. Bacteria vaginitis characterized, their antimicrobial susceptibility pattern determined.The overall...
Rapid and sensitive Tuberculosis (TB) diagnosis closer to patients is a key global TB control priority. Truenat assays (MTB, MTB Plus, MTB-RIF Dx) are new molecular diagnostic tools for the detection of Rifampicin (RIF)-resistance from sputum samples. The accuracy needed prior implementation in clinical use Ethiopia. This study aimed determine sensitivity specificity assays; compare Xpert MTB/RIF assay.
Abstract The Mycobacterium tuberculosis complex (MTBC) includes several human- and animal-adapted pathogens. It is thought to have originated in East Africa from a recombinogenic canettii -like ancestral pool. Here, we describe the discovery of clinical strain isolated Ethiopia that shares archetypal phenotypic genomic features M. strains, but represents phylogenetic branch much closer MTBC clade than strains. Analysis traces horizontal gene transfer this isolate previously identified...
Both passive and active surveillance of drug resistance have an important role in tuberculosis (TB) control program. Surveillance data are to estimate the magnitude TB, know trend disease, assess performance program, forecast diagnosis treatment supplies. Therefore, this study aimed determine prevalence proportion resistant Ethiopia based on passively collected data. A cross-sectional was conducted at National Tuberculosis Reference Laboratory seven Regional TB laboratories a retrospective...
The rise of drug-resistant tuberculosis (DR-TB) has presented a substantial challenge to the national (TB) control program. Understanding epidemiology pre-extensively (pre-XDR-TB) could help clinicians adapt MDR-TB treatment regimens at an earlier stage. This study aimed assess second-line anti-TB drug resistance among patients in Ethiopia using routine laboratory-based data.
IntroductionThere is a global gap between tuberculosis incident cases and the notified cases. Active household contact investigation one of strategies to narrow this gap. It has advantage giving early diagnosis preventive treatment vulnerable eligible groups. This study assessed practice adherence in central Ethiopia.MethodA cross-sectional covering all registered bacteriologically confirmed pulmonary patients their close contacts was conducted Ethiopia from January 1, 2022, December 30,...
This study aimed to determine the frequencies and trends of Mycobacterium tuberculosis rifampicin resistance among presumptive patients in Ethiopia, who were tested using Xpert MTB/RIF assay between 2014 2021. Data collected retrospectively from patient registries. Laboratory-based data extracted national (TB) referral laboratory database. All referred National Tuberculosis Reference Laboratory (NTRL) for TB diagnosis all over country March 1, September 30, 2021, assay, included. The entered...
Introduction The quality of tuberculosis laboratory services in health facilities is a mandatory component detecting active pulmonary TB cases and treatment follow-up. However, ensuring the test results concern. This study aimed to assess assurance practices diagnostic Ethiopia. Materials methods A cross-sectional was conducted from October 2018 March 2019 at nine governmental TB-culture laboratories 34 randomly selected GeneXpert® MTB/RIF (Xpert® MTB/RIF) testing Participating were...
There is limited information on the performance of Xpert
Abstract Introduction Data on the burden of bacteriologically confirmed childhood Tuberculosis (PTB) and drug-resistant TB in Ethiopia is limited due to difficulties related its diagnosis this population. Therefore, study aimed assess PTB Case Notification Rates (CNRs) Drug Resistant-Tuberculosis among children Ethiopia. Method Retrospective secondary clinical laboratory data were obtained from 3rd round national DR-TB survey which was conducted between August 2017 January 2019. We used IBM...
Abstract Background: Xpert MTB/RIF Assay is currently used in Ethiopia for the rapid diagnosis of Mycobacterium tuberculosis (MTB) and mutations that confer Rifampicin resistance. resistance determined based on any mutation 81 bp rpoB gene using five overlapping probes represented as Probe A (codons 507–511), B 512–518), C 518–523), D 523–529) E 529–533). In this review, we assessed frequency missed probe types Resistance results. Methods: Data were reviewed from specimens received tested...
Background: Drug resistance in tuberculosis poses challenges to both the control and prevention of disease. The extent is not well known developing countries, including Ethiopia. This study was conducted determine drug patterns mutation characteristics Mycobacterium among extra pulmonary patients selected health facilities Addis Ababa. Material Methods: A cross-sectional from February 2022 August hospitals Socio-demographic clinical data were collected using structured questionnaire. complex...
Abstract Background: Xpert® MTB/RIF assay is currently used in Ethiopia for the rapid diagnosis of Mycobacterium tuberculosis (MTB) and mutations that confer Rifampicin resistance. resistance determined based on any mutation 81 bp rpoB gene using five overlapping probes represented as Probe A (codons 507–511), B 512–518), C 518–523), D 523–529) E 529–533). In this review, we assessed frequency missed probe types Resistance results. Methods: Data were reviewed from specimens received tested...