A5016181634- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Biosimilars and Bioanalytical Methods
- Virus-based gene therapy research
- T-cell and B-cell Immunology
- Silicon Carbide Semiconductor Technologies
- Viral Infectious Diseases and Gene Expression in Insects
- Nanowire Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Immunodeficiency and Autoimmune Disorders
- Aging, Health, and Disability
- Ferroptosis and cancer prognosis
- Mycobacterium research and diagnosis
- Chemokine receptors and signaling
- Immune cells in cancer
- Photodynamic Therapy Research Studies
Moffitt Cancer Center
2019-2025
Universidad Nacional de Córdoba
2015-2021
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2021
Cordoba University
2016
Trisomy 21 (T21) causes Down syndrome (DS), a condition characterized by high prevalence of autoimmune disorders. However, the molecular and cellular mechanisms driving this phenotype remain unclear. Building upon our previous finding that T cells from people with DS show increased expression interferon (IFN)-stimulated genes, we have completed comprehensive characterization peripheral cell compartment in adults without conditions. CD8+ are depleted naïve subsets enriched for differentiated...
Background Co-stimulatory signals regulate the expansion, persistence, and function of chimeric antigen receptor (CAR) T cells. Most studies have focused on co-stimulatory domains CD28 or 4-1BB. CAR cell persistence is enhanced by 4-1BB co-stimulation leading to nuclear factor kappa B (NF-κB) signaling, while resistance exhaustion mutations domain. Methods We hypothesized that a third-generation containing with only PYAP signaling motif (mut06) would provide beneficial aspects both. designed...
Immune checkpoint blockade has been largely unsuccessful for the treatment of bone metastatic castrate-resistant prostate cancer (mCRPC). Here, we report a combinatorial strategy to treat mCRPC using γδ-enriched chimeric antigen receptor (CAR) T cells and zoledronate (ZOL). In preclinical murine model mCRPC, γδ CAR-T targeting stem cell (PSCA) induced rapid significant regression established tumors, combined with increased survival reduced cancer-associated disease. Pretreatment ZOL, U.S....
The aging process is accompanied by altered immune system functioning and an increased risk of infection. Dendritic cells (DCs) are antigen-presenting that play a key role in both adaptive innate immunity, but how affects DCs their influence on immunity has not been thoroughly established. Here we examined the function conventional (cDCs) old mice after TLR7 stimulation, focusing ability to cross-prime CD8+ T cells. Using polyU, synthetic ssRNA analog, as ligand OVA antigen (Ag) model, found...
The immune response against cancer generated by type-I-interferons (IFN-1) has recently described. Exogenous and endogenous IFN-/β have an important role in surveillance control of tumor development. In addition, IFN-1s emerged as novel DAMP for the consecutive events connecting innate adaptive immunity they also been postulated essential requirement induction immunogenic cell death (ICD). this context, Photodynamic therapy (PDT) previously linked to ICD. PDT consists administration a...
<title>Abstract</title> Chimeric antigen receptor (CAR) T cell therapies have revolutionized B malignancy treatment, but subsets of patients with large lymphoma (LBCL) experience primary resistance or relapse after CAR treatment. To uncover tumor microenvironment (TME)-induced mechanisms, we examined patients’ intratumoral immune infiltrates and observed that elevated levels immunoregulatory macrophages in pre-infusion biopsies are correlated poor clinical responses. cell-produced...
An important challenge in cancer immunotherapy is to expand the number of patients that benefit from immune checkpoint inhibitors (CI), a fact has been related pre-existence an efficient antitumor response. Different strategies are being proposed promote tumor immunity and be used combined therapies with CI. Recently, we reported intratumoral administration naked poly A:U, dsRNA mimetic empirically early clinical trials some success, delays growth prolongs mice survival several murine...
Abstract Background Characterization of breast cancer (BC) through the determination conventional markers such as ER, PR, HER2, and Ki67 has been useful a predictive therapeutic tool. Also, assessment tumor-infiltrating lymphocytes proposed an important prognostic aspect to be considered in certain BC subtypes. However, there is still need identify additional biomarkers that could add precision distinguishing response individual patients. To this end, we focused expression interferon...
Abstract The crucial role that endogenously produced IFN-β plays in eliciting an immune response against cancer has recently started to be elucidated. Endogenous important surveillance and control of tumor development. Accordingly, the TLR agonists as therapeutic agents is being revisited via strategy intra/peritumoral injection with idea stimulating production endogenous type I IFN inside tumor. Polyadenylic-polyuridylic acid (poly A:U) a dsRNA mimetic explored empirically immunotherapy...
The mechanisms that link inflammatory responses to cancer development remain a subject of intense investigation, emphasizing the need better understand cellular and molecular pathways create tumor promoting microenvironment. myeloid differentiation primary response protein MyD88 acts as main adaptor molecule for signaling cascades initiated from Toll-like receptors (TLRs) interleukin 1 receptor (IL-1R). has been shown contribute tumorigenesis in many inflammation-associated models. In this...
<h3>Background</h3> Co-stimulatory signals regulate the expansion, persistence, and function of chimeric antigen receptor (CAR) T cells. Most studies have focused on co-stimulatory domains CD28 or 4-1BB. CAR cell persistence is enhanced by 4-1BB co-stimulation leading to NF-κB signaling, while resistance exhaustion mutations domain. <h3>Methods</h3> We hypothesized that a third-generation containing with only PYAP signaling motif (mut06) would provide beneficial aspects both. designed...
Abstract Bone metastasis is a frequent complication in advanced prostate cancer, with the resultant lesions significantly contributing to patient morbidity and mortality. While next generation hormone ablation therapies bone protecting bisphosphonates alleviate these symptoms, disease remains incurable, new therapeutic approaches are of urgent need. In this regard, we have focused on tapping tumor-seeking potential chimeric antigen receptor (CAR) T cells. CAR cells shown remarkable...
Bone metastasis is a frequent complication in advanced prostate cancer, with the resultant lesions significantly contributing to patient morbidity and mortality. While next generation hormone ablation therapies bone protecting bisphosphonates alleviate these symptoms, disease remains incurable, new therapeutic approaches are of urgent need. In this regard, we have focused on tapping tumor-seeking potential chimeric antigen receptor (CAR) T cells. CAR cells shown remarkable anti-tumor...
Abstract Among the variables affecting CAR-T cell function, evidence shows that CAR architecture is a common factor influencing clinical outcomes. Previously, we demonstrated 2nd generation (gen.) targeting prostate stem antigen (PSCA) was more efficient than 3rd gen. counterpart, in preclinical model of pancreatic adenocarcinoma. This superior anti-tumor capacity associated with greater tonic signaling. To further characterize this phenomenon, compared antitumor activity and phenotype two...
An amendment to this paper has been published and can be accessed via the original article.