A5101422073- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Genomics and Rare Diseases
- Biosimilars and Bioanalytical Methods
University of Toronto
2023-2024
Hospital for Sick Children
2023
SickKids Foundation
2023
Great Ormond Street Hospital
2023
University College London
2023
Abstract Commercial pharmacogenetic testing panels capture a fraction of the genetic variation underlying medication metabolism and predisposition to adverse reactions. In this study we compared in six pharmacogenes detected by whole genome sequencing (WGS) targeted commercial panel cohort 308 individuals with family history pediatric heart disease. 1% cohort, WGS identified rare variants that altered interpretation metabolizer status would thus prevent potential errors gene-based dosing.
Abstract Commercial pharmacogenetic testing panels capture a fraction of the genetic variation underlying medication metabolism and predisposition to adverse reactions. In this study we compared in five pharmacogenes detected by whole genome sequencing (WGS) targeted commercial panel cohort 308 individuals with family history pediatric heart disease. 1% cohort, WGS identified rare variants that altered interpretation metabolizer status would thus prevent potential errors gene-based dosing.