A5000894411- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Boron Compounds in Chemistry
- Cancer-related molecular mechanisms research
- Membrane Separation and Gas Transport
- Organoboron and organosilicon chemistry
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- RNA modifications and cancer
- Circular RNAs in diseases
- Structural Health Monitoring Techniques
- Membrane Separation Technologies
- Immune Cell Function and Interaction
- Orthopedic Infections and Treatments
- Seismic Performance and Analysis
- Covalent Organic Framework Applications
- Acute Myeloid Leukemia Research
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Vibration Control and Rheological Fluids
- Immune cells in cancer
- Environmental Toxicology and Ecotoxicology
- Neurobiology and Insect Physiology Research
- Inflammation biomarkers and pathways
Children's Hospital of Fudan University
2019-2025
China University of Petroleum, East China
2018-2024
Shanghai Jiao Tong University
2020-2024
Center for Children
2024
Shanghai Children's Medical Center
2024
Beijing Tongren Hospital
2021-2024
Yulin University
2024
Heilongjiang University
2021-2024
Fuwai Yunnan Cardiovascular Hospital
2024
Tongji University
2023
Rationale: Macrophages play critical roles in the pathogenesis of type 1 diabetes mellitus (T1DM). Circular RNAs (circRNAs) are a novel class endogenous with covalently closed loop structures, implicated various disease processes. However, their impact on macrophage activation and T1DM remains elusive. Methods: circRNA expression profiles peripheral blood mononuclear cells (PBMCs) from children were determined by whole transcriptome microarray. Bioinformatics, quantitative real-time PCR,...
PTPRE-AS1 deficiency aggravates pulmonary inflammation but reduces colitis severity by modulating M2 macrophage activation.
Abstract N 6 -methyladenosine (m A), the most prevalent mRNA modification, has an important function in diverse biological processes. However, involvement of m A allergic asthma and macrophage homeostasis remains largely unknown. Here we show that methyltransferases METTL3 is expressed at a low level monocyte-derived macrophages from childhood patients. Conditional knockout Mettl3 myeloid cells enhances Th2 cell response aggravates airway inflammation by facilitating M2 activation. Loss gain...
This study aimed to analyze the profiles and evolution of Staphylococcus aureus in pediatric intensive care units (PICUs) 17 hospitals China from 2016 2022. Susceptibility testing was performed bacterial strains with a uniform monitoring protocol, which provided by US Clinical Laboratory Standards Institute (CLSI) used Antimicrobial Surveillance Network (CHINET). The results were interpreted accordance performance standards for antimicrobial susceptibility issued Institute. Twenty-six...
There is a recent global surge in Mycoplasma pneumoniae pneumonia (MPP). However, the key immune factors that contribute to advancement of disease remain unknown. Hence, we conducted this study uncover immunological profile children affected by MPP. This enrolled visiting Children's Hospital Fudan University from December 2023 April 2024, including 34 healthy controls, 51 severe MPP (S-MPP), 27 non-severe (NS-MPP), and non-MPP (NMP) cases. Their blood samples were analyzed using flow...
Previous studies have indicated that miR-146a-5p acts as an oncogene in several types of cancer, yet a tumor suppressor gene others. In non-small cell lung cancer (NSCLC), one report showed it was downregulated and played the role suppressor. However, another study overexpressed serum NSCLC patients compared to healthy controls. Therefore, is obvious further function necessary fully understand its importance. Herein, we verified miR- 146a- 5p NSCLC. Our data revealed expression level...
Lung cancer is the leading cause in all deaths. A low survival rate and high recurrence of lung make endeavor to identify new, more effective therapies a primary goal. MicroRNAs (miRNAs) are regarded as regulators tumorigenesis it known that miR-183-5p significantly upregulated non-small cell (NSCLC), suggesting has an oncogenic function cancer. In this study, we found could promote carcinogenesis by directly targeting phosphatase tensin (PTEN). Further experiments indicated suppress p53...
Lung cancer is one of the most common malignant diseases globally, composed non-small cell lung (NSCLC, 85%) and small (SCLC, 15%). MicroRNAs (miRNAs) are single-stranded noncoding RNAs having important roles in development. miR-411-5p/3p were reported to be increased significantly human NSCLC tissues lines. Moreover, overexpression could accelerate proliferation migration, impede apoptosis Mechanically, SPRY4 confirmed a direct target miR-411-5p/3p. Furthermore, our findings showed that...
An efficient in situ Pd-NHC catalytic system for regioselective arylation of B(3,6)-H bonds o-carborane has been developed the first time. A series symmetric and unsymmetric 3,6-diaryl-o-carboranes anchored with active groups have synthesized moderate to good yields under mild conditions. This work offers an protocol selective activation important value design coupling reactions functionalization o-carboranes.
Abstract Background We aimed to comprehensively evaluate the immunologic landscape at baseline and upon chemotherapy in cervical cancer. The information should aid ongoing clinical investigations of checkpoint blockade immunotherapies this disease setting. Methods A series 109 carcinoma patients was retrospectively assayed before after neoadjuvant chemotherapy. Tumour-infiltrating immune markers (CD3, CD4, CD8, CD20, CD56, CD68, PD-1, PD-L1) were assessed by immunohistochemistry. RNA...
Circular RNAs (circRNAs) constitute a class of covalently circular non-coding RNA molecules formed by 5′ and 3′ end back-splicing. The rapid development bioinformatics large-scale sequencing has led to the identification functional circRNAs. Despite an overall upward trend, studies focusing on roles circRNAs in immune diseases remain relatively scarce. In present study, we obtained differential circRNA expression profile based microarray analysis peripheral blood mononuclear cells (PBMCs)...
This study presents a relatively easy method to use bioderived carbon material from poplar and nanotubes as electrode materials in supercapacitors. After delignification, powder was intercalated with acidized multiwalled nanotubes, boric acid, melamine. Subsequently, after carbonization activation treatment, supercapacitor exhibiting high electrochemical characteristics were prepared. The obtained multistage porous achieved pore volume reaching 0.86 cm3 g–1 well specific surface area 1500.5...
Degradation of the endothelial glycocalyx is critical for sepsis-associated lung injury and pulmonary vascular permeability. We investigated whether sulodexide, a precursor synthesis glycosaminoglycans, plays biological role in remodeling improves barrier dysfunction sepsis.The number children with septic shock that were admitted to PICU at Children's Hospital Fudan University who enrolled study was 28. On days one three after enrollment, venous blood samples collected, heparan sulfate,...
By changing the charge distribution of boron vertices via introducing an amide on cage B(9), selective B(4) arylation o-carboranes Suzuki-Miyaura coupling has been developed. A series o-carborane derivatives decorated with diverse active groups have synthesized moderate to good yields, which proved be further transformed a novel kind tri-substituted nido-carborane fused oxazole potential application in neutron capture therapy, organometallic as well coordination chemistry.
A selective mono-/tetraacetoxylation of o-carboranes with acetic acid via cross dehydrogenative coupling cage B–H/O–H bonds has been developed, and a series mono- tetraacetoxylated have synthesized moderate to good yields as well selectivity. Mechanistic studies indicate that the acetoxyl originates from directly, nucleophilic addition PdIV-oxo species dehydration process is proposed.
An efficient and succinct protocol for synthesis of bis(o-carborane) connected by a B–B bond via palladium catalyzed oxidative dehydrogenative coupling cage B–H/B–H bonds was developed the first time. A series bis(o-carborane)s B(4)–B(4)′ B(4)–B(5)′ synthesized with moderate to good yields. This work opens door miscellaneous applications in related disciplines has important value design different kinds biscarboranes.
Abstract Exosomes are an important carrier for cell communication. miRNAs in exosomes potential biomarkers and therapeutic targets different types of cancer. However, the role exosomal medulloblastoma (MB) patients is largely unknown. In this study, we reported that there was a higher level miR-130b-3p derived from MB patient plasma compared with healthy control plasma. could transfer to line played suppressor roles proliferation. suppressed tumorigenesis by targeting previously unknown...
One type of low-cost and eco-friendly organic‒inorganic superabsorbent composite (SAPC) was synthesized by free radical polymerization acrylic acid (AA), starch (ST), sodium alginate (SA) kaolin (KL) in aqueous solution. The structure morphology the SAPC were characterized Fourier transform infrared spectrometer (FT-IR), scanning electron microscope (SEM), X-ray diffraction (XRD) thermogravimetric analysis (TGA). influence different reaction conditions on water absorption SAPC, i.e., SA KL...