A5046272391- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Aortic Disease and Treatment Approaches
- Acute Myeloid Leukemia Research
- Aortic aneurysm repair treatments
- Congenital Heart Disease Studies
- Eosinophilic Disorders and Syndromes
- Cardiac Structural Anomalies and Repair
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Hemoglobinopathies and Related Disorders
- Kawasaki Disease and Coronary Complications
- Platelet Disorders and Treatments
- Infective Endocarditis Diagnosis and Management
- Infectious Aortic and Vascular Conditions
- Cardiac Arrhythmias and Treatments
- Chronic Lymphocytic Leukemia Research
- Coronary Artery Anomalies
- Tracheal and airway disorders
- Antimicrobial Resistance in Staphylococcus
- CNS Lymphoma Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Vascular anomalies and interventions
- Cardiac and Coronary Surgery Techniques
Juntendo University
2010-2025
Yamagata University
2020-2024
Juntendo University Urayasu Hospital
2024
Juntendo University Hospital
2024
Miyagi Children's Hospital
2023
Yamagata University Hospital
2020-2021
Nihonkai General Hospital
2020
Boston University
2019
Seattle University
2019
We have previously reported the establishment of a Staphylococcus aureus laboratory strain, 10 3d1, having reduced susceptibility to daptomycin and heterogeneous vancomycin-intermediate S. (VISA) phenotype. The strain was generated in vitro by serial selection (Camargo, I. L., H. M. Neoh, L. Cui, K. Hiramatsu, Antimicrob. Agents Chemother. 52:4289-4299, 2008). Here we explored genetic mechanism resistance whole-genome sequencing producing gene-replaced strains. By genome comparison between...
The features on computed tomographic (CT) scans of nonalcoholic fatty liver were investigated in 24 patients with related to overweight. CT examinations performed before and after 3 months a low-calorie diet. reversibility infiltration during diet therapy could be monitored by changes appearance repeated scans. Hepatic steatosis improved, as assessed from increases attenuation values the diet, improvement was accompanied decrease elevated serum glutamic-pyruvic transaminase activity. these...
ABSTRACT We previously reported a novel phenotype of vancomycin-intermediate Staphylococcus aureus (VISA), i.e., “slow VISA,” whose colonies appear only after 72 h incubation. Slow-VISA strains can be difficult to detect because prolonged incubation is required and the unstable. To develop method for detection slow-VISA isolates, we studied 23 isolates derived from heterogeneous VISA (hVISA) clinical strain Mu3. identified single nucleotide polymorphisms (SNPs) in genes involved various...
Vancomycin-intermediately resistant Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) are associated with treatment failure. hVISA contains only a subpopulation of cells increased minimal inhibitory concentrations, its detection is problematic because it classified as vancomycin-susceptible by standard susceptibility testing the gold-standard method for impractical in clinical microbiology laboratories. Recently, research group developed machine-learning classifier to distinguish...
Summary Somatic mutations in the calreticulin ( CALR ) gene have been found most patients with JAK 2 ‐ and MPL ‐unmutated Philadelphia chromosome‐negative myeloproliferative neoplasms MPN s). It has recently shown that mutant constitutively activates thrombopoietin receptor and, thus, plays a causal role development of s. However, roles human haematopoietic cell differentiation remain predominantly elusive. To examine impact 5‐base insertion (Ins5) on differentiation, we generated induced...
Since MPL mutation is a rare driver gene found in small number of essential thrombocythemia (ET) patients, the clinical characteristics patients with mutations and their association thrombotic events have not yet been elucidated Japan.We enrolled 579 Japanese ET based on diagnostic criteria WHO classification 2017 compared MPL-mutated (n = 22; 3.8%) to JAK2V617F-mutated 299; 51.6%), CALR-mutated 144; 24.9%), triple-negative (TN) 114; 19.7%) patients.Thrombosis during follow up was observed 4...
Summary Risk‐adapted therapy is recommended to prevent major clinical complications, such as thrombo‐haemorrhagic events, in patients with essential thrombocythaemia (ET). In this study, we analysed the association between non‐driver gene mutations and events 579 ET. ASXL1 TP53 were frequently identified ET complicated by thrombosis (22.7% 23.1%, respectively), DNMT3A mutation was who experienced haemorrhage (15.2%). Multivariate analyses of thrombosis‐free survival (TFS) revealed that are...
There are currently 2 representative diagnostic criteria for essential thrombocythemia (ET), the 2014 British Committee Standards in Hematology Guidelines (BCSH) and 2016 World Health Organization (WHO) criteria. We compare discuss advantages disadvantages of criteria.We applied to 403 patients with thrombocytosis suspected myeloproliferative neoplasms (MPN) compared patient populations.The BCSH diagnosed ET 279 (BCSH-ET) whereas WHO 203 (WHO-ET). were 83 diagnosable only by (BCSH-only-ET),...
Immune checkpoint inhibitors (ICIs) are widely used for the treatment of various cancers. However, paradoxical exacerbation neoplasms, referred to as "hyperprogressive disease," has been reported in a proportion patients treated with anti-programmed cell death-1 (PD-1)/PD-1 ligand (PD-L1) blockade. We herein report case acute adult T-cell leukemia (ATL) that developed shortly after administration nivolumab, PD-1 inhibitor, treat non-small-cell lung cancer. There were no signs ATL before and...
In myelodysplastic/myeloproliferative neoplasms (MDS/MPN) with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T), somatic mutation in the Splicing Factor 3B subunit 1 gene (SF3B1) at rate of approximately 85% was concurrently found one MPN driver mutations, such as JAK2 V617F (50%), calreticulin (CALR) exon 9 (1–3%) MPL W515 (0–3%) mutations (Patnaik Tefferi 2017). Impaired erythropoiesis induced by mutant SF3B1 (Mupo et al, 2017, Obeng 2016), an increase or more lineages blood cells...
Total arch replacement using the frozen elephant trunk procedure is performed for true lumen expansion of descending aorta in patients with type A acute aortic dissection. However, remodelling effect on dissected unclear. We aimed to evaluate postoperative after surgery. Between December 2012 and January 2020, we retrospectively investigated 24 who underwent total Remodelling was evaluated computed tomography. The effect, based ratio, determined (i) DeBakey (type I versus III retrograde);...
Abstract A subset of essential thrombocythemia (ET) cases are negative for disease-defining mutations on JAK2 , MPL and CALR defined as triple (TN). The lack recurrent in TN-ET patients makes its pathogenesis ambiguous. Here, we screened 483 with suspected ET a single institution, centrally reviewed bone marrow specimens, identified 23 patients. Analysis clinical records revealed that were mostly young female, without history thrombosis or progression to secondary myelofibrosis leukemia....
Background: Aggressive mature T-cell lymphoma (TCL) is a disease that carries poor prognosis. Methods: We analyzed the expression of 22 tumor cell functional proteins in 16 randomly selected patients with TCL. Immunohistochemistry was performed paraffin-embedded tissue sections to determine protein statuses cells. Results: Glucose-regulated 94 (GRP94), serves as pro-survival component under endoplasmic reticulum (ER) stress microenvironment, significantly associated shortened survival....
A proportion of patients with polycythemia vera (PV) and essential thrombocythemia (ET) harbor non-driver mutations associated poor prognosis. In this study, we analyzed the frequency in a large Japanese PV ET cohort. Furthermore, studied relationship these prognosis patients.We enrolled 843 or ET. Non-driver were by target resequencing using next-generation sequencing. The association was estimated multivariable logistic regression analysis log-rank test.Non-driver detected 31.1% 24.5% ET,...
A 77-year-old man with myelodysplastic syndrome suffered from duodenal perforation after undergoing endoscopic submucosal dissection (ESD) for treatment of cancer. He presented hemorrhagic shock, peritonitis and disseminated intravascular coagulation (DIC), received transfusions red blood cells (RBC), fresh frozen plasma (FFP), γ-globulin albumin (Alb). One month the last RBC transfusion, prolonged thrombocytopenia was observed, platelet concentrate (PC) transfused. However, immediately...
Chemotherapy for hemodialysis (HD) patients is a challenging situation because HD are generally frail, and the pharmacokinetics pharmacodynamics of most chemotherapeutics in unknown. We report classical Hodgkin lymphoma (cHL) patient successfully treated with 34 courses brentuximab vedotin (BV) monotherapy, which 30 were carried out during HD. Although grade 2 peripheral sensory neuropathy one occasion febrile neutropenia observed, treatment was well-tolerated overall effective. This first...