A5058307071- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Retinal Development and Disorders
- Pluripotent Stem Cells Research
- RNA and protein synthesis mechanisms
- Connexins and lens biology
- Ocular Oncology and Treatments
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Immunotherapy and Immune Responses
- melanin and skin pigmentation
Ginkgo BioWorks (United States)
2024
New York Genome Center
2019-2020
Bard College
2015
Abstract Using mRNA as a therapeutic has received enormous attention in the last few years, but instability of molecule remains hurdle to achieving long-lasting levels protein expression. In this study, we describe our approach for designing stable molecules by combining machine learning-driven sequence design with high-throughput experimental assays. We developed massively parallel reporter assay (MPRA) that, single experiment, measures half-life tens thousands unique sequences containing...
Genetic and genomic studies of brain disease increasingly demonstrate disease-associated interactions between the cell types brain. Increasingly complex more physiologically relevant human-induced pluripotent stem (hiPSC)-based models better explore molecular mechanisms underlying but also challenge our ability to resolve type-specific perturbations. Here, we report an extension RiboTag system, first developed achieve type-restricted expression epitope-tagged ribosomal protein (RPL22) in...
Uveal melanoma is the most common intraocular cancer, with an estimated 2000 cases diagnosed yearly in U.S. Tumors arise from melanocytes choroid, iris, and ciliary body. Treatment typically includes proton beam therapy, as such, availability of tissue samples for research limited. Approximately 50% patients disease develop untreatable liver metastases within 15 years. There urgent need to animal model uveal melanoma, order discover new therapeutics understand initiation progression.
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Abstract Genetic and genomic studies of brain disease increasingly demonstrate disease-associated interactions between the cell types brain. Increasingly complex more physiologically relevant human induced pluripotent stem (hiPSC)-based models better explore molecular mechanisms underlying disease, but also challenge our ability to resolve cell-type specific perturbations. Here we report an extension RiboTag system, first developed achieve restricted expression epitope-tagged ribosomal...