A5058528695- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Risk Factors
- Cardiac Health and Mental Health
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Protease and Inhibitor Mechanisms
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiac Structural Anomalies and Repair
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- Aortic aneurysm repair treatments
- Health Systems, Economic Evaluations, Quality of Life
- Coronary Interventions and Diagnostics
The University of Texas Southwestern Medical Center
2024-2025
Southwestern Medical Center
2024-2025
Brigham and Women's Hospital
2022-2024
National Heart Institute
2024
Abstract Background Hemofiltration during and after cardiopulmonary bypass (CPB) reduces levels of proinflammatory cytokines total interstitial body water. Because economic causes, hemofilters became less available in low- middle-income countries, which forced the perfusionists to use hemodialyzers instead. This study aimed assess clinical outcomes pediatric patients who had instead CPB. We performed a retrospective cohort 46 underwent cardiac surgery between January 1st, 2023, September...
Introduction: The recent AHA presidential advisory on Cardiovascular-Kidney-Metabolic Syndrome (CKM) proposed a novel staging scheme, but limited data exist regarding CKM stage prevalence in the community. Prior population-based studies have lacked subclinical imaging measures, and not reported variability by age, gender, race/ethnicity. Methods: We estimated population of stages Dallas County, from among 2,817 participants population-sampled Heart Study who attended study Visit 1...
Background: Limited data exist on American College of Cardiology/American Heart Association valvular heart disease (VHD) stage prevalence, progression, and association with incident cardiovascular diseases in late life. Methods: Participants the ARIC study (Atherosclerosis Risk Communities), a prospective community-based cohort study, underwent protocol echocardiography at visits 5 (2011–2013) 7 (2018–2019), their aortic stenosis, regurgitation, mitral regurgitation were defined according to...
Abstract Background The Secondary Manifestations of Arterial Disease (SMART) risk score was recommended by the European Society Cardiology (ESC) to estimate a 10-year for myocardial infarction, stroke, or vascular death in individual patients with clinically manifested atherosclerotic disease (ASCVD).(1) An updated SMART2 algorithm developed and recalibrated according population risks different world regions except Africa. expected-observed ratio recurrent ASCVD very high-risk region study...
Background: Prior metabolomics studies in aortic stenosis (AS) have focused on patients with severe and their response to intervention. Limited data exist regarding circulating metabolites predictive of AS development. Aim: Identify associated valve (AV) hemodynamics incident AV events. Hypothesis: We hypothesized that large-scale can identify novel relevant Methods: Among participants the community-based ARIC cohort study who underwent protocol echocardiography metabolomic profiling by...
Abstract Background Instantaneous wave-free ratio (iwFR) is a well-validated method for functional evaluation of intermediate coronary lesions. A recently developed Murray law-based QFR (µQFR) allows wire-free FFR estimation using high-quality single angiographic projection. We aim to determine the diagnostic accuracy µQFR as compared wire-based iwFR physiological assessment lesions in sample Egyptian patients. Results Over one-year period, patients who previously underwent an stenosis...
Introduction: Although prevalence of aortic stenosis (AS) is increasing, little known regarding circulating proteins predictive AS development. Hypothesis: Novel associated with hemodynamics and clinical outcomes can be discovered using plasma proteomics. Methods: In the community-based Atherosclerosis Risk in Communities study, we measured proteomics SOMAscan aptamer-affinity assay (n=4,877 aptamers; Somalogic Inc.) at study Visits 3 (V3; 1992-94; n=11,430) 5 (V5; 2011-2013; n=4,899)....
Background: Despite the increasing prevalence of aortic stenosis (AS) and associated morbidity, limited data exist regarding circulating risk factors for AS development. Methods: Among Atherosclerosis Risk in Communities study participants with available proteomics (Somascan v4) at Visit 5 (2011-13; n=4,899; age 76 ± years, 57% women), we used multivariable linear regression to evaluate association 4,877 plasma proteins peak valve (AV) velocity AV dimensionless index. We then tested their...
Background: Left atrial (LA) enlargement and fibrillation (AF) are associated with functional mitral regurgitation (MR). It is unknown whether lower (worse) LA function MR progression, independent of size, in individuals without AF. Hypothesis: We hypothesized that was higher odds progression. Aims: To evaluate the association echocardiographic-based progression Atherosclerosis Risk Communities (ARIC) Study, a community-based cohort. Methods: included 2,444 ARIC participants (mean age, 73.8...
Background: Aortic stenosis (AS) is associated with significant morbidity and mortality increasing in prevalence. Limited data exist regarding circulating biomarkers of AS risk. Methods: Among Atherosclerosis Risk Communities study participants available proteomics (Somascan v4) at Visit 5 (2011-13; n=4,899; age 76 ± years, 57% women), we used multivariable linear regression to evaluate the association 4,877 plasma proteins peak aortic valve (AV) velocity AV dimensionless index. We then...
Introduction: The AHA/ACC framework of valvular heart disease (VHD) stages emphasizes the progressive nature VHD. Limited data exist regarding association VHD with prognostic cardiac biomarkers myocardial stress (NT-proBNP) and injury (high sensitivity troponin-T [hs-TnT]). Methods: Among 6,078 participants in community-based Atherosclerosis Risk Communities (ARIC) who underwent echocardiography at 5 th study visit (2011-2013) were free prior valve replacement, we classified based on...
Introduction: AHA/ACC guidelines endorse the conceptual framework of valvular heart disease (VHD) stages to emphasize progressive nature VHD. However, our knowledge, no community-based estimates prevalence VHD exist, particularly in late-life when is highest. Methods: Among 6,118 participants Atherosclerosis Risk Communities (ARIC) study who underwent comprehensive echocardiography at 5 th visit (2011-2013), were defined based on guideline recommendations. The association stage with...