A5017332761- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Reproductive Biology and Fertility
- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Muscle Physiology and Disorders
- Evolution and Genetic Dynamics
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Nematode management and characterization studies
- Technology Assessment and Management
- Genetics, Bioinformatics, and Biomedical Research
- Congenital heart defects research
- Microtubule and mitosis dynamics
- Insect and Arachnid Ecology and Behavior
- Plant Virus Research Studies
- Axon Guidance and Neuronal Signaling
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Genomics and Chromatin Dynamics
- Photosynthetic Processes and Mechanisms
- Genetics and Physical Performance
- Insect Resistance and Genetics
- RNA Research and Splicing
University of California, Riverside
2014-2023
Ohio Wesleyan University
2011
University of California, Santa Barbara
2000-2010
University of Regina
1998
University of Alberta
1995-1996
A spontaneous mutation affecting locomotion of the nematode Caenorhabditis elegans has been mapped to a new gene, unc-119. Phenotypic characterization mutants suggests defect does not lie in musculature and that animals also have defects feeding behavior chemosensation. unc-119 physically relative previously identified chromosomal break linkage group III, DNA clones covering region can rescue mutant phenotype transgenic animals. Three more alleles at locus, with identical phenotypes, induced...
ABSTRACT Dicer enzymes process virus-specific double-stranded RNA (dsRNA) into small interfering RNAs (siRNAs) to initiate specific antiviral defense by related interference (RNAi) pathways in plants, insects, nematodes, and mammals. Antiviral RNAi Caenorhabditis elegans requires Dicer-related helicase 1 (DRH-1), not found plants insects but highly homologous mammalian retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), intracellular viral sensors that trigger innate immunity...
The C. elegans MS blastomere, born at the 7-cell stage of embryogenesis, generates primarily mesodermal cell types, including pharynx cells, body muscles and coelomocytes. A presumptive null mutation in T-box factor gene tbx-35, a target MED-1 MED-2 divergent GATA factors, was previously found to result profound decrease production MS-derived tissues, although tbx-35(-) embryonic arrest phenotype variable. We report here that NK-2 class homeobox ceh-51 is direct TBX-35 least one other...
Development of the vulva in C. elegans is mediated by combinatorial action several convergent regulatory inputs, three which,the Ras, Wnt and Rb-related pathways, act regulating expression thelin-39 Hox gene. LIN-39 specifies cell fates regulates fusion mid-body region, leading to formation vulva. In lateral seam epidermis, differentiation have been shown be regulated two GATA-type transcription factors, ELT-5 -6. We report that encoded egl-18 gene, which was previously promote a functional...
In C. elegans, many mesodermal cell types are made by descendants of the progenitor MS, born at seven-cell stage embryonic development. Descendants MS contribute to body wall muscle and posterior half pharynx. We have previously shown that is specified activity divergent MED-1,2 GATA factors. report target gene tbx-35, which encodes a T-box transcription factor, specifies fate. Embryos homozygous for putative tbx-35-null mutation fail generate MS-derived pharynx muscle, instead ectopic...
Lymphoid enhancer factor/T-cell factor (LEF/TCF) are transcription factors that mediate the Wnt signaling pathway, and have crucial roles during embryonic development in various organisms. Here we report acetylation enhances nuclear retention of POP-1, Caenorhabditis elegans LEF/TCF homolog, through increasing import blocking export. We identify three lysines acetylated vivo, demonstrate their essential requirement for proper localization biological activity POP-1 C. embryogenesis. The...