A5103268584- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Birth, Development, and Health
- Genetic Associations and Epidemiology
- Mental Health Research Topics
- Health disparities and outcomes
- Neuroscience and Neuropharmacology Research
- Optimism, Hope, and Well-being
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Neuroendocrine regulation and behavior
- Identity, Memory, and Therapy
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Health, Environment, Cognitive Aging
- Genetics and Neurodevelopmental Disorders
- Psychological Well-being and Life Satisfaction
- Personality Traits and Psychology
- Aging and Gerontology Research
- Exercise and Physiological Responses
- Stroke Rehabilitation and Recovery
- Epigenetics and DNA Methylation
- Anesthesia and Neurotoxicity Research
- Autism Spectrum Disorder Research
Washington University in St. Louis
2020-2025
Cargill (United States)
2023
Rutgers, The State University of New Jersey
2014-2020
University of Kansas Medical Center
1967-1991
Personality influences many aspects of the health process. It is unclear to what extent self- and informant-reports Big Five offer incremental validity for prediction inflammatory biomarkers whether inflammation provides a unique pathway between personality indicators physical health, independent behaviors.Using data from older adults (N = 1,630) enrolled in St. Louis Aging Network study, we tested informant-reported traits show associations with (IL-6, CRP, TNF-α). Further, behaviors...
Inflammation has been reliably associated with depression. However, the directionality of this association is poorly understood, evidence that elevated inflammation may promote and precede development depression, as well arise following its expression. Using data from older adults (N = 1,072, ages 60-73) who participated in ongoing longitudinal St. Louis Personality Aging Network (SPAN) study, we examined whether inflammatory markers (interleukin-6: IL-6, C-reactive protein: CRP, tumor...
Abstract Objectives: Purposeful adults may experience greater cognitive resilience because sense of purpose help buffer against the effects depressive symptoms and loneliness. We also evaluated whether these associations differed by race. Design: This study uses a wave self-report data from SPAN psychosocial aging. Setting: Participants come representative sample older in St. Louis. Participants: ( N = 595) ages range 65 to 78 M age 71.46), with 18.3% participants identifying as...
ABSTRACTCognitive gerontology research requires consideration of performance as well perceptions performance. While subjective memory is positively associated with performance, these correlations typically are modest in magnitude, leading to the need consider whether certain people may show weaker or stronger linkages between and perceptions. The current study leveraged personality (NEO Big Five), (i.e., word recall), ability metamemory adulthood decline) data from St. Louis Personality...
COVID-19 remains a significant international public health concern. Yet, the mechanisms through which symptomatology emerges remain poorly understood. While SARS-CoV-2 infection may induce prolonged inflammation within central nervous system, evidence primarily stems from limited small-scale case investigations. To address this gap, our study capitalized on longitudinal UK Biobank neuroimaging data acquired prior to and following testing (N=416 including n=224 cases; M
COVID-19 remains a significant international public health concern. Yet, the mechanisms through which symptomatology emerges remain poorly understood. While SARS-CoV-2 infection may induce prolonged inflammation within central nervous system, evidence primarily stems from limited small-scale case investigations. To address this gap, our study capitalized on longitudinal UK Biobank neuroimaging data acquired prior to and following testing (N = 416 including n 224 cases; Mage 58.6). Putative...
The gamma-aminobutyric acid (GABA)-shift hypothesis proposes that GABA agonist action is excitatory early in development and transitions to an inhibitory role later life. In experiment 1, the nonspecific agonist, valproic (VPA), was administered pregnant C57BL/6 mice on embryonic day 13. Fetal maternal brains were harvested 2 h post-VPA exposure assayed for nuclear factor erythroid 2-related (NRF2) H3 expression through western blot analysis. 2, VPA neonatal pups P14 adult P60. both...
Stress-induced dysregulation of diurnal cortisol is a cornerstone stress-disease theories; however, observed associations between cortisol, stress, and health have been inconsistent. The reliability features may contribute to these equivocal findings. Our meta-analysis (5 from 11 studies; total participant n = 3307) investigation (15 features) in 2 independent studies (St. Louis Personality Aging Network [SPAN] Study, 147, ages 61-73; Minnesota Longitudinal Study Risk Adaptation [MLSRA] 90,...
Abstract BACKGROUND C-reactive protein (CRP) is a moderately heritable marker of systemic inflammation that associated with adverse physical and mental health outcomes. Identifying factors genetic liability to elevated CRP in childhood may inform our understanding variability could be targeted prevent and/or delay the onset related METHODS We conducted phenome-wide association study (PheWAS) risk for (i.e. polygenic score [PRS]) among children genetically similar European ancestry reference...
Abstract Black-White racial health disparities in America are striking. Black Americans have worse physical and lower life expectancy than White Americans. However, the potential factors contributing to increased mortality later among rarely investigated. Here, we examined longitudinal St. Louis Personality Aging Network (SPAN) Study of older adults (n=1,630; aged 55-65 at baseline; 67.4% White; 32.6% Black), with data collected from National Death Index. SPAN participants had greater over...
Inflammation has been reliably associated with depression. However, the directionality of this association is poorly understood, evidence that elevated inflammation may promote and precede development depression arise following its expression. Using data from older adults (N = 1,072, ages 60-73) who participated in ongoing longitudinal St. Louis Personality Aging Network (SPAN) study, we examined whether inflammatory markers (interleukin-6: IL-6, C-reactive protein: CRP, tumor necrosis...
The frequent comorbidity of psychiatric and physical health conditions may be partially attributable to early life stress-related changes in inflammatory signaling behavior (e.g., borderline personality pathology, behaviors) that reciprocally maintain enhance their effects on overall health. Using data from older adults (N=1,630) who participated the ongoing longitudinal St Louis Personality Aging Network (SPAN) study, we examined associations between childhood abuse, inflammation markers...