A5087902544- Trypanosoma species research and implications
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Research on Leishmaniasis Studies
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Structure and Function
- Toxin Mechanisms and Immunotoxins
- Biochemical and Molecular Research
- Genetics and Neurodevelopmental Disorders
- Protein Structure and Dynamics
- Signaling Pathways in Disease
- Eicosanoids and Hypertension Pharmacology
- Protease and Inhibitor Mechanisms
- Pharmacogenetics and Drug Metabolism
- Connective tissue disorders research
- Protein Interaction Studies and Fluorescence Analysis
- Enzyme Catalysis and Immobilization
University of Sheffield
2025
University of the Free State
2020-2022
Universidade Federal do Rio de Janeiro
2005-2013
Baeyer-Villiger monooxygenases (BVMOs) are flavin-dependent enzymes that primarily convert ketones to esters, but can also catalyze heteroatom oxidation. Several structural studies have highlighted the importance of ‘control loop’ in BVMOs, which adopts different conformations during catalysis. Central is a conserved tryptophan has been implicated NADP(H) binding. BVMOAFL210 from Aspergillus flavus, however, contains threonine equivalent position. Here, we report structure complex with NADP+...
Selective oxyfunctionalization of non-activated C–H bonds remains a major challenge in synthetic chemistry. The biocatalytic hydroxylation by cytochrome P450 monooxygenases (CYPs), however, offers catalysis with high regio- and stereoselectivity using molecular oxygen. CYP153s are class CYPs known for their selective terminal n-alkanes microorganisms, such as the bacterium Alcanivorax dieselolei, have evolved extensive enzymatic pathways various lengths n-alkanes, including CYP153 to yield...