A5007564213- Cystic Fibrosis Research Advances
- Antibiotic Resistance in Bacteria
- Inhalation and Respiratory Drug Delivery
- Antibiotic Use and Resistance
- Nematode management and characterization studies
- Antifungal resistance and susceptibility
- Infectious Diseases and Mycology
- Clostridium difficile and Clostridium perfringens research
- Invertebrate Immune Response Mechanisms
- Evolution and Genetic Dynamics
- Urinary Tract Infections Management
- Pediatric health and respiratory diseases
- Malaria Research and Control
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
Queen Elizabeth University Hospital
2021-2025
NHS Greater Glasgow and Clyde
2013-2023
University of Stirling
2016-2020
Gartnavel General Hospital
2013
Dalhousie University
1982
Abstract The increase in antibiotic resistant bacteria poses a threat to the continued use of antibiotics treat bacterial infections. overuse and misuse has been identified as significant driver emergence resistance. Finding optimal treatment regimens is therefore critical ensuring prolonged effectiveness these antibiotics. This study uses mathematical modelling analyse effect traditional have on dynamics infection. Using novel approach, genetic algorithm, then identifies improved regimens....
Background Elexacaftor/tezacaftor/ivacaftor (ETI) was made available to eligible women in September 2020 by NHS Scotland. Methods Retrospective data collection for the 13 pregnancies taking ETI from West of Scotland Adult Cystic Fibrosis Unit, 2020–December 2023. Results Mean pre-pregnancy FEV1 2.26L, 70% predicted (range 1.25–3.19); (38–86% predicted). post-pregnancy 2.29L, 71% 1.49–3.40); (45–92% The mean age at conception (29 years) and percentage (70%) were higher than other UK studies....
To investigate factors affecting aminoglycoside clearance in adult patients with cystic fibrosis who received multiple courses of antibiotic therapy over a period up to 15 years.Aminoglycoside concentration-time data and relevant clinical characteristics were collated from pharmacokinetic databases established Glasgow, Scotland The Hague, Netherlands. Data Glasgow (1993-2009) used for population model development; Hague (2002-11) validation. NONMEM was determine structural covariate models,...
Mass production and use of antibiotics has led to the rise resistant bacteria, a problem possibly exacerbated by inappropriate non-optimal application. Antibiotic treatment often follows fixed-dose regimens, with standard dose antibiotic administered equally spaced in time. But are such regimens optimal or can alternative be designed increase efficacy? Yet, few mathematical models have aimed identify treatments based on biological data infections inside living host. In addition, assumptions...
An infection control program was instituted at The Victoria General Hospital, an 800-bed acute care hospital, in July 1977. Serratia marcescens had infected or colonized (I/C) 225 to 232 patients yearly for each of the three previous years. Since this organism is usually acquired nosocomially, we decided use I/C as a marker our program. During years 1977 1980, identified and eliminated several reservoirs (contaminated urine measuring containers, urometers, diabetic testing equipment in-use...
<h3>Objectives</h3> Cystic fibrosis is a devastating life-limiting genetic condition characterised by progressive decline in lung function, respiratory infections and premature death. Tezacaftor-ivacaftor combined cystic transmembrane conductance regulator (CFTR) modulator that targets the underlying cause of disease. This study aimed to assess impact tezacaftor-ivacaftor use routine clinical practice for adults with fibrosis. <h3>Methods</h3> A retrospective observational longitudinal...