A5046835574- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- T-cell and Retrovirus Studies
- CAR-T cell therapy research
- Immune cells in cancer
- Inflammation biomarkers and pathways
- Immune Response and Inflammation
- Endometrial and Cervical Cancer Treatments
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
University Medical Center Groningen
2014-2022
University of Groningen
2014-2022
Dialyse Centrum Groningen
2014
The chemokine CXCL13 mediates recruitment of B cells to tumors and is essential for the formation tertiary lymphoid structures (TLSs). TLSs are thought support antitumor immunity associated with improved prognosis. However, it remains unknown whether formed in response general inflammatory character tumor microenvironment, or rather, induced by (neo)antigen-specific adaptive immunity. We here report on finding that TGFβ-dependent CD103+CD8+ tumor-infiltrating T-cell (TIL) subpopulation...
Epithelial Ovarian cancer (EOC) is the most lethal gynecological malignancy and has limited curative therapeutic options. Immunotherapy for EOC promising, but clinical efficacy remains restricted to a small percentage of patients. Several lines evidence suggest that low response rate might be improved by combining immunotherapy with carboplatin paclitaxel, standard-of-care chemotherapy EOC. Here, we assessed immune contexture tumors, draining lymph nodes, peripheral blood mononuclear cells...
Activation of STimulator INterferon Genes (STING) is important for induction anti-tumor immunity. A dysfunctional STING pathway observed in multiple cancer types and associates with poor prognosis inferior response to immunotherapy. However, the association between virally induced cancers such as HPV-positive cervical remains unknown. Here, we investigated prognostic value protein levels using tumor tissue microarrays two patient groups, primarily treated surgery (n = 251) or...
Abstract DNA‐sensing receptor Cyclic GMP–AMP Synthase (cGAS) and its downstream signaling effector STimulator of INterferon Genes (STING) have gained significant interest in the field tumor immunology, as a dysfunctional cGAS‐STING pathway is associated with poor prognosis worse response to immunotherapy. However, studies so far not taken into account polymorphic nature STING‐encoding STING1 gene. We hypothesized that presence allelic variance would cause variation between individuals their...
Identification of human cancer-reactive CD8+ T cells is crucial for the stratification patients immunotherapy and determination immune-therapeutic effects. To date, these have been identified mainly based on cell surface expression programmed death protein 1 (PD-1) or co-expression CD103 CD39. A small subset CD103- CD39+ also present in tumors, but little known about cells. Here, we report that from mismatch repair-deficient endometrial tumors are activated characterized predominantly by...
<div>Abstract<p>The chemokine CXCL13 mediates recruitment of B cells to tumors and is essential for the formation tertiary lymphoid structures (TLSs). TLSs are thought support antitumor immunity associated with improved prognosis. However, it remains unknown whether formed in response general inflammatory character tumor microenvironment, or rather, induced by (neo)antigen-specific adaptive immunity. We here report on finding that TGFβ-dependent...
<div>Abstract<p>The chemokine CXCL13 mediates recruitment of B cells to tumors and is essential for the formation tertiary lymphoid structures (TLSs). TLSs are thought support antitumor immunity associated with improved prognosis. However, it remains unknown whether formed in response general inflammatory character tumor microenvironment, or rather, induced by (neo)antigen-specific adaptive immunity. We here report on finding that TGFβ-dependent...
<p>Supplementary Figures 1-3 with legends</p>
<p>Supplementary Figures 1-3 with legends</p>