A5038819687- DNA and Nucleic Acid Chemistry
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Education and Critical Thinking Development
- DNA Repair Mechanisms
- Engineering Education and Curriculum Development
- Advanced biosensing and bioanalysis techniques
- International Student and Expatriate Challenges
- Garlic and Onion Studies
- Genomics and Chromatin Dynamics
- Global Education and Multiculturalism
- Bacterial Genetics and Biotechnology
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- RNA Research and Splicing
Broad Institute
2022-2025
Harvard University
2022-2025
Harvard University Press
2024
Wesleyan University
2017-2020
University of Tulsa
2015
University of Wisconsin–Madison
1958
Cis-regulatory elements (CREs) control gene expression and are dynamic in their structure function, reflecting changes the composition of diverse effector proteins over time1. However, methods for measuring organization at CREs across genome limited, hampering efforts to connect CRE function cell fate disease. Here we developed PRINT, a computational method that identifies footprints DNA-protein interactions from bulk single-cell chromatin accessibility data multiple scales protein size....
Allium roots grown in C14-thymidine and H3-thymidine media were treated with N hydrochloric acid at 60°C. as standard Feulgen hydrolysis. The retention of the radioactive thymidine DNA a function hydrolysis time was studied autoradiographically. No significant loss label detected until extended beyond optimal for staining. data are consistent assumption that there is no during normal material used.
Abstract (Session Topics Preferences: Comparison and Assessment of Various Study Abroad Models inAchieving Global Competencies; Preparing Engineering Students For International Practice;Engineering Education Responses to Challenges) Identifying Factors That Enhance Undergraduate Students’ Preparedness As the nature engineering work grows increasingly more global, both academic industry stakeholders have widely acknowledged necessity for graduates effectively with peers from diverse national...
Cancer initiation is driven by the cooperation between genetic and epigenetic aberrations that disrupt gene regulatory programs critical to maintaining specialized cellular functions. After initiation, cells acquire additional alterations influenced tumor-intrinsic -extrinsic mechanisms, which increase intratumoral heterogeneity, reshape cell's underlying networks promote cancer evolution. Furthermore, environmental or therapeutic insults drive selection of heterogeneous cell states, with...
Abstract An Inductive Qualitative Analysis of Student Interviews on Engineering Global PreparednessInternational experiences are viewed as an essential component engineering education. Yetlittle has been done to operationally define global preparedness, specify the variousalternatives for achieving or determine what degree preparednessis result personal attributes, prior experiences, curricular/ co-curricular/extra-curricularexperiences. This paper discusses preliminary research findings...
<h3>Background</h3> T cells are part of the immune system's adaptive defence; they specifically target and kill both virally infected cancerous through antigen recognition. Unfortunately, cancer can exploit intrinsic cell mechanisms to survive attack by system. exhaustion arises from chronic stimulation, which shifts a portion population exhausted state (T<sub>EX</sub>), resulting in diminished proliferation tumor/viral clearance. Modern genome engineering technologies have potential...
The Holliday junction is a four‐way DNA structure formed during the process of double strand break repair and recombination in meiosis. Branch migration vital molecular for transfer genetic information from parents to offspring. Understanding this relative base pair composition can provide better picture overall its connection short inverted repeats that have been linked chromosome instability. We used fluorescent nucleoside analog,...