A5044009212- Monetary Policy and Economic Impact
- Financial Risk and Volatility Modeling
- Statistical Methods and Inference
- Market Dynamics and Volatility
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- Stochastic processes and financial applications
- Economic theories and models
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Complex Systems and Time Series Analysis
- Advanced Statistical Methods and Models
- Forecasting Techniques and Applications
- Protein Structure and Dynamics
- Financial Markets and Investment Strategies
- Cystic Fibrosis Research Advances
- DNA and Nucleic Acid Chemistry
- Antibiotic Resistance in Bacteria
- RNA Interference and Gene Delivery
- Advanced Memory and Neural Computing
- Chronic Myeloid Leukemia Treatments
- Advanced biosensing and bioanalysis techniques
- Statistical Distribution Estimation and Applications
- Spectroscopy and Quantum Chemical Studies
- RNA and protein synthesis mechanisms
University of Calgary
2015-2024
University of Surrey
2014-2024
Ospedale San Bortolo
2022-2024
International Renal Research Institute of Vicenza
2024
The University of Melbourne
2023
Institute for Fiscal Studies
2016-2021
University of Richmond
2021
University of Oxford
2021
Singapore Management University
2015-2016
Hospital Madre Teresa
2015
Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Our current understanding the detailed organization cell remains rather elusive, because challenge to study fluctuating nanoscale assemblies with required spatiotemporal resolution. Here, we use molecular dynamics simulations characterize lipid environment 10 membrane proteins. To provide a realistic environment, are embedded model plasma membrane, where more than 60 species represented,...
Article1 September 2017Open Access Source DataTransparent process Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD Kiran Bountra Department of Life Sciences, Imperial College London, UK Rutherford Appleton Laboratory, Research Complex at Harwell, Oxfordshire, Search more papers this author Gregor Hagelueken Institute Physical and Theoretical Chemistry, University Bonn, Germany Hassanul G Choudhury Valentina Corradi Centre Molecular Simulation...
Lipid membranes are central to cellular life. Complementing experiments, computational modeling has been essential in unraveling complex lipid-biomolecule interactions, crucial both academia and industry. The Martini model, a coarse-grained force field for efficient molecular dynamics simulations, is widely used study membrane phenomena but faced limitations, particularly capturing realistic lipid phase behavior. Here, we present refined 3 models with mapping scheme that distinguishes tails...
Clive W.J. Granger has summarized his personal viewpoint on testing for causality in numerous articles over the past 30 years and outlined what he considers to be a useful operational version of original definition causality, which notes is partially alluded Ph.D. dissertation Norbert Wiener. This based comparison one-step-ahead predictive ability competing models. However, concludes discussion by noting that it common practice test using in-sample F-tests. The type tests continues...
Nosocomial infections with Enterococcus faecalis are an emerging health problem. However, drug efflux pumps contributing to intrinsic resistance poorly studied in this Gram-positive pathogen. In study, we functionally investigated seven heterodimeric ABC transporters of E. that annotated as pumps. Deletion ef0789-ef0790 on the chromosome resulted increased susceptibility daunorubicin, doxorubicin, ethidium, and Hoechst 33342, corresponding transporter was named EfrCD. Unexpectedly,...
Polyunsaturated fatty acids (PUFAs), but not saturated acids, modulate ion channels such as the cardiac KCNQ1 channel, although mechanism is completely understood. Using both simulations and experiments, we find that PUFAs interact directly with channel via two different binding sites: one at voltage sensor pore. These amphiphilic pockets stabilize negatively charged PUFA head group by electrostatic interactions R218, R221, K316, while hydrophobic tail selectively stabilized cassettes of...
Journal Article Semi-Parametric Comparison of Stochastic Volatility Models using Realized Measures Get access Valentina Corradi, Corradi Queen Mary, University London Search for other works by this author on: Oxford Academic Google Scholar Walter Distaso Imperial College The Review Economic Studies, Volume 73, Issue 3, July 2006, Pages 635–667, https://doi.org/10.1111/j.1467-937X.2006.00390.x Published: 01 2006 history Received: January 2004 Accepted: November 2005
Pharmacophores—three-dimensional (3D) arrangements of essential features enabling a molecule to exert particular biological effect—constitute very useful tool in drug design both hit discovery and hit-to-lead optimization process. Two basic approaches for pharmacophoric model generation can be used by chemists, depending on the availability or not target 3D structure. In view rapidly growing number protein structures that are now available, receptor-based pharmacophore methods becoming more...
Resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitor imatinib mesylate (IM) is most often due point mutations in the <i>Bcr-Abl</i> fusion gene. T315I mutation (resulting substitution Ile for a Thr residue at "gatekeeper" position 315) raises particular concern, because it also provides resistance second-generation inhibitors already approved clinical use (nilotinib and dasatinib). Much effort therefore focused on alternative molecular-based strategies. Previous studies...
SignificanceCholesterol is one of the main components found in plasma membranes and involved lipid-dependent signaling enabled by integral membrane proteins such as inwardly rectifying potassium (Kir) channels. Similar to other ion channels, most Kir channels are down-regulated cholesterol. One very few notable exceptions Kir3.4, which up-regulated this important lipid. Here, we discovered characterized a molecular switch that controls impact (up-regulation vs. down-regulation) cholesterol...