A5016662682- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Bacterial Genetics and Biotechnology
- Bioinformatics and Genomic Networks
- Health, Environment, Cognitive Aging
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- RNA and protein synthesis mechanisms
- Biochemical and Structural Characterization
- Mycorrhizal Fungi and Plant Interactions
- Microbial Metabolism and Applications
- Single-cell and spatial transcriptomics
- Molecular Biology Techniques and Applications
- Photosynthetic Processes and Mechanisms
- CRISPR and Genetic Engineering
- Identification and Quantification in Food
- Receptor Mechanisms and Signaling
- Fungal and yeast genetics research
- Plant Pathogens and Fungal Diseases
- Protist diversity and phylogeny
Brigham and Women's Hospital
2024-2025
Harvard University
2023-2025
Massachusetts General Hospital
2024-2025
Science for Life Laboratory
2019-2021
Uppsala University
2017-2021
University of Iowa
2013
Abstract Motivation Cancer is the second leading cause of death worldwide, and although there have been advances in treatments, including immunotherapies, these often require biopsies which can be costly invasive to obtain. Due lack pre-emptive cancer detection methods, many cases are detected at a late stage when definitive symptoms appear. Plasma samples relatively easy obtain, they used monitor molecular signatures ongoing processes body. Profiling cell-free DNA popular method for...
A gram-negative, budding, catalase negative, oxidase positive and non-motile bacterium (MBLW1T) with a complex endomembrane system has been isolated from freshwater lake in southeast Queensland, Australia. Phylogeny based on 16S rRNA gene sequence analysis places the strain within family Planctomycetaceae, related to Zavarzinella formosa (93.3 %), Telmatocola sphagniphila %) Gemmata obscuriglobus (91.9 %). Phenotypic chemotaxonomic demonstrates considerable differences type strains of...
Abstract Bacteria of the Planctomycetes phylum have many unique cellular features, such as extensive membrane invaginations and ability to import macromolecules. These features raise intriguing questions about composition their cell envelopes. In this study, we used microscopy, phylogenomics, proteomics examine evolution envelope proteins in Tuwongella immobilis other members Planctomycetes. Cryo-electron tomography data indicated a distance 45 nm between inner outer membranes T. immobilis....
The Planctomycetes bacteria have unique cell architectures with heavily invaginated membranes as confirmed by three-dimensional models reconstructed from FIB-SEM images of Tuwongella immobilis and Gemmata obscuriglobus. subcellular proteome T. was examined differential solubilization followed LC-MS/MS analysis, which identified 1569 proteins in total. Tris-soluble fraction contained mostly cytoplasmic proteins, while inner outer membrane were found the Triton X-100 SDS-soluble fractions,...
Bacteria of the phylum Planctomycetes have a unique cell plan with an elaborate intracellular membrane system, thereby resembling eukaryotic cells. The origin and evolution these remarkable features is debated. To study evolutionary genomics bacteria complex architectures, we resequenced 9.2-Mb genome model organism Gemmata obscuriglobus sequenced 10-Mb G. massiliana Soil9, 7.9-Mb CJuql4, 6.7-Mb Tuwongella immobilis, all which belong to family Gemmataceae. A gene flux analysis revealed...
ABSTRACT Cancer is the second leading cause of death worldwide, and although there have been advances in treatments, including immunotherapies, these often require biopsies which can be costly invasive to obtain. Due lack pre-emptive cancer detection methods, many cases are detected at a late stage when definitive symptoms appear. Plasma samples relatively easy obtain, they used monitor molecular signatures ongoing processes body. Profiling cell-free DNA popular method for monitoring cancer,...