A5087199842- Celiac Disease Research and Management
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Viral Infections and Immunology Research
- Microscopic Colitis
- Hemispheric Asymmetry in Neuroscience
- Mental Health Research Topics
- Treatment of Major Depression
- Digital Mental Health Interventions
- Sepsis Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Systemic Lupus Erythematosus Research
- RNA Research and Splicing
- Regulation of Appetite and Obesity
- Multiple Sclerosis Research Studies
- Restless Legs Syndrome Research
- Tracheal and airway disorders
- Male Reproductive Health Studies
- T-cell and B-cell Immunology
- Sexual function and dysfunction studies
- Diabetes and associated disorders
- Adolescent Sexual and Reproductive Health
- Hemodynamic Monitoring and Therapy
- Musculoskeletal pain and rehabilitation
- Neonatal Respiratory Health Research
European Biomedical Research Institute of Salerno
2023-2024
Ceinge Biotecnologie Avanzate (Italy)
2023
Agostino Gemelli University Polyclinic
2022
Institute of Genetics and Biophysics
2019-2021
Ospedale Versilia
2019
Eating Disorders (EDs) affect individuals globally and are associated with significant physical mental health challenges. However, access to adequate treatment is often hindered by societal stigma, limited awareness, resource constraints.
Timing and adequacy of peritoneal source control are the most important pillars in management patients with acute peritonitis. Therefore, early prognostic evaluation peritonitis is paramount to assess severity establish a prompt appropriate treatment. The objectives this study were identify clinical laboratory predictors for in-hospital mortality develop warning score system, based on easily recognizable assessable variables, globally accepted.This worldwide multicentre observational...
HLA DQA1*05 and DQB1*02 alleles encoding the DQ2.5 molecule DQA1*03 DQB1*03 DQ8 molecules are strongly associated with celiac disease (CD) type 1 diabetes (T1D), two common autoimmune diseases (AD). We previously demonstrated that genes showed a higher expression respect to non-CD in heterozygous positive (HLA DR1/DR3) antigen presenting cells (APC) of CD patients. This differential affected level encoded on APC surface established strength gluten-specific CD4+ T response. Here, we expanded...
Major Depressive Disorder (MDD) is a prevalent mental health condition characterized by persistent low mood, cognitive and physical symptoms, anhedonia (loss of interest in activities), suicidal ideation. The World Health Organization (WHO) predicts depression will become the leading cause disability 2030. While biological markers remain essential for understanding MDD's pathophysiology, recent advancements social signal processing environmental monitoring hold promise. Wearable...
Abstract The DR5-DQ7/DR7-DQ2 genotype is very frequent among patients affected by celiac disease (CD), in Europe. This genotype, associated to high risk of CD, carries the HLA- DQA1*05 and DQB1*02 predisposing alleles, trans configuration. alleles encode DQ2.5 heterodimer responsible gluten peptide presentation on surface antigen-presenting cells (APCs), consequent pathogenic CD4 + T cell activation. We demonstrated that DR5/DR7 APCs induce an anti-gluten response, comparable intensity...
Macrophages play an important role in the pathogenesis of celiac disease (CD) because they are involved both inflammatory reaction and antigen presentation. We analyzed expression CD-associated HLA-DQ2.5 risk alleles on macrophages isolated by two cohorts adult patients, from U.S. Italy, at different stages with genotypes. After isolating differentiating PBMC, we assessed HLA genotype quantified mRNAs qPCR, before after gliadin stimulation. The results confirmed differences between...
Post-traumatic emotional distress follows exposure to trauma and may be affected by atypical cerebral lateralisation. We aimed explore the relationship between handedness dysfunction in people exposed a nat-ural disaster.About 22 months after an earthquake, 326 adults completed Edinburgh Handedness Inventory, Impact of Events Scale-Revised, Insomnia Severity Index.Mixed-handed people, compared right-handed, had 3.3 fold increase odds have distress. Consistent left-handers scored higher than...
HLA class II genes encode highly polymorphic heterodimeric proteins functioning to present antigens T cells and stimulate a specific immune response. Many are strongly associated with autoimmune diseases as they self-antigen CD4+ driving pathogenic responses against host tissues or organs. High expression of risk is diseases, influencing the strength T-mediated The regulated at both transcriptional post-transcriptional levels. Protein components RNP complex binding 3′UTR affecting mRNA...
Abstract HLA gene expression has an important role in the autoimmune disease predisposition. We investigated mRNA profile of risk alleles HLA‐DRB1*15 and HLA‐DRB1*13 a cohort subjects both multiple sclerosis (MS) patients healthy controls. Moreover, we explored allele HLA‐DRB1*11 that is very frequent our from southern Italy. found MS‐associated heterozygous MS was always higher than nonassociated alleles. The differential occurred also nonaffected subjects, though with lower increment...
The introduction of newborn screening for cystic fibrosis (CF) increased diagnosis screen positive inconclusive (CFSPID). We described the case a 12-month-old boy with CFSPID who, during summer, presented Pseudo-Bartter syndrome no diagnostic criteria CF.
Mindfulness and forgiveness can contribute to decreased rumination, which in turn has been found play an important role sleep problems, such as insomnia poor quality. The authors explored rumination a potential explanatory variable underlying the association of mindfulness with quality, model encompassing different facets controlling for interpersonal dispositional forgiveness. One hundred adults (74% females, Mage = 27.62, SD 8.11) completed measures Mindfulness, Forgivingness, Rumination,...
Abstract We have previously demonstrated that the expression of HLA class II genes is regulated by binding a ribonucleoprotein complex affects mRNA processing. identified protein components transcripts encoding HLA-DR molecule. Here we investigate whether same RNA proteins interact with 3’UTR mRNAs HLA-DQ isotype. Specifically, focused on HLA-DQ2.5 molecule, expressed surface antigen presenting cells, and representing main susceptibility factor for celiac disease (CD). This encoded...