ABSTRACT Aim This study aims to provide a comprehensive analysis of keratinocytes, the predominant cell type in epidermis, by examining their structural, functional, and regulatory roles skin biology. The explores intricate processes keratinocyte differentiation, proliferation, immune interactions, emphasizing essential contributions homeostasis, wound healing, barrier integrity. Additionally, it investigates involvement keratinocytes dermatological disorders such as psoriasis, atopic...

Abstract Background Alopecia areata (AA) is an autoimmune condition characterized by sudden and unpredictable hair loss, with a lifetime incidence of 2%. AA can be divided into three categories: patchy alopecia, alopecia totalis, universalis. It affect person's psychological health overall quality life. Elevated C‐reactive protein (CRP) levels in the liver may indicate inflammatory response diseases. Vitamin D, essential for immune system control skin health, related to AA. Hair follicles...

Abstract Background MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression in diverse biological processes. They hold promise as therapeutic candidates for targeting human disease pathways, although our understanding of their regulatory mechanism remains incomplete. Alopecia areata (AA) is a prevalent inflammatory ailment distinguished by the infiltration T cells anagen‐stage hair follicles. The scarcity effective remedies AA may stem from limited regarding its precise...

Priapism is an emergency condition treated by medicine (EM) physicians and urologists/andrologists. EM are the first-line healthcare providers for this condition, their knowledge, attitudes, practices regarding priapism remain unclear. The aim of study was to understand physicians' perspectives help re-structure programs. This cross-sectional on attitude, practice (KAP) surveyed from a university other hospitals in Ismailia governorate, Egypt. A validated questionnaire sent via online...

Alopecia areata (AA), is a common autoimmune nonscarring alopecia. Vitamin D involved in various biological processes such as immune regulation, cellular growth, and specialization, well the maintenance of hair cycle. We aimed to explore impact different Tru9I variant genotypes on serum vitamin levels receptor (VDR) gene expression. Case-control study that included 72 individuals diagnosed with AA, along age sex matched healthy controls individuals. Blood samples were obtained measure level...

Depigmentation of specific areas the skin is a persistent and long-lasting dermatologic disorder known as vitiligo, stemming from impairment disruption melanocytes both structurally functionally, leading to loss pigmentation in those regions.

Acne is a frequently diagnosed skin condition that causes pilosebaceous apparatus clogs and/or inflammatory responses in the majority of teenagers. It multifactorial disease can develop due to various factors. We aimed evaluate lipid profiles and hormonal levels patients with acne correlate them severity. also aim explore alteration their effect on occurrence acne.

Abstract Background Acne vulgaris (AV) is a chronic, multifactorial inflammatory disease of the pilosebaceous unit brought on by hormonal imbalance, excessive sebum production, follicular hyperkeratinization, inflammation and Cutibacterium acne . patients are characterized alteration lipid profile. Apolipoprotein B gene (ApoB) plays an essential role in lipoprotein biosynthesis multiple single‐nucleotide polymorphisms (SNPs) ApoB associated with dyslipidemia. Aim The aim this study was to...

Abstract Background MicroRNAs (miRNAs) are small RNA molecules that play a regulatory role in various biological processes by acting as intracellular mediators. They hold great potential therapeutic agents for targeting human disease pathways; however, there is still much to be uncovered about their mechanism of gene regulation. Alopecia areata (AA) commonly occurring inflammatory condition characterized the infiltration T cells specifically target anagen‐stage hair follicle. The limited...

Macrophage scavenger receptor 1 gene (MSR1), is responsible for producing macrophage receptors. MSR1 primarily located on the surfaces of various types and known to exert a range effects human body. These include influencing innate adaptive immunological reactions, as well contributing development conditions such atherosclerosis, dyslipidemia, liver lung disease, cancer. The unregulated assimilation lipoproteins by leads creation macrophages rich in cholesterol that manifest foam-like cells,...

Background and Aim: Psoriasis is a chronic, relapsing inflammatory multisystemic disease with both genetic predisposition autoimmune pathogenic traits. Several types of vitamin D receptor (VDR) polymorphisms have been investigated as predisposing factor for psoriasis susceptibility controversial results. However, the exact pathophysiological effect VDR gene on remains poorly understood. We aimed to determine whether polymorphisms, specifically rs7975232 (ApaI), afford in given community...

Insulin resistance (IR) is a condition where cells become resistant to insulin, causing impaired glucose uptake and increased blood levels. Interleukin-12 (IL-12), cytokine, regulates the immune system. High levels of IL-12 can lead chronic inflammation, exacerbate contribute type 2 diabetes. Also, link IR acne vulgaris (AV), as it reduces tissue sensitivity insulin sebum production, which development.

Many clinical features of psoriasis include a rash with itchy, scaly patches, most frequently on the knees, elbows, trunk, and scalp. By studying genes involved receptivity, pathologic pathways become clearer more understood.To predict participation rs1544410 in serum vitamin D levels (SDL) psoriasis, susceptibility, severity.One hundred five patients were categorized by body surface area as mild, moderate, severe. SDL genetic analysis performed using polymerase chain reaction standard...

Psoriasis is a chronic, non-contagious autoimmune condition marked by dry, itchy,erythematous and scaly plaques. From modest, localized plaques to total body coverage, the severity of psoriasis varies. Plaque, guttate, inverted, pustular, erythrodermic are five primary kinds. About 90% cases plaque psoriasis, commonly known as vulgaris. Study aims determine impact an rs2228570 (FokI) variant rs11568820 (CDX2) on serum vitamin D levels (SVD) in patients with correlation between two variants...

Several types of polymorphisms in vitamin D receptor (VDR) have been found psoriasis.This study looked at the role TaqI polymorphism VDR gene as a factor changing plasma 25-hydroxyvitamin [25(OH)D] levels psoriasis patients and to see if it had any relationship with disease severity.Clinical examination, serum 25(OH)D level measurement, molecular studies genotyping by PCR RFLP were performed for two groups.The T/t genotypes most common patients, while t/t more abundant healthy subjects. The...

Abstract Background Acne vulgaris (AV) is a chronic inflammatory skin condition affecting the pilosebaceous unit, commonly presenting as comedones, papules, pustules, or nodules on face, upper limbs, torso, and back, with comedones formation being primary pathology leading to disfiguring inflammation, hyperpigmentation, scarring, psychological impact. Aim The purpose of this study was investigate significance two genetic variants in promoter region tumor necrosis factor‐alpha (TNF‐α) gene...