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Research Areas
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
Centre for Genomic Regulation
2021
Abstract Background Somatic cell reprogramming is the process that allows differentiated cells to revert a pluripotent state. In contrast extensively studied rewiring of epigenetic and transcriptional programs required for reprogramming, dynamics post-transcriptional changes their associated regulatory mechanisms remain poorly understood. Here we study alternative splicing occurring during efficient mouse B into induced stem (iPS) compare them those embryonic fibroblasts. Results We observe...
10.1186/s13059-021-02372-5
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Genome biology
2021-06-03
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