A5012195020- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Coenzyme Q10 studies and effects
- Cancer Genomics and Diagnostics
- Aortic Disease and Treatment Approaches
- Biochemical effects in animals
- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Advanced battery technologies research
- Cancer-related molecular mechanisms research
- Zebrafish Biomedical Research Applications
- Connective tissue disorders research
- Erythropoietin and Anemia Treatment
- Advanced Battery Technologies Research
- Aortic aneurysm repair treatments
- Blood properties and coagulation
- Advanced Biosensing Techniques and Applications
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Pregnancy-related medical research
- Metabolism and Genetic Disorders
- Protein purification and stability
Army Medical University
2024-2025
Xinqiao Hospital
2024-2025
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Dalian Medical University
2024
Virginia Tech
2023
Johns Hopkins Medicine
2021
Johns Hopkins University
2021
People's Liberation Army 401 Hospital
2020
Chinese People's Liberation Army
2020
Abstract Background The protective effect of Coenzyme Q10 (CoQ10) on the cardiovascular system has been reported, however, whether it can promote early recovery cardiac function and alleviate remodeling after myocardial infarction (MI) remains to be elucidated. Whether CoQ10 may regulate macrophage-mediated pro-inflammatory response MI its potential mechanism are worth further exploration. Methods To determine baseline plasma levels by LC-MS/MS, healthy controls patients ( n = 11 each) with...
Vaginally delivered nanoformulations of progesterone and histone deacetylase inhibitors prevent inflammation-induced preterm birth in mice.
The genome-wide DNA methylation profile, or methylome, is a critical component of the overall epigenomic landscape that modulates gene activities and cell fate. Single-cell methylomic studies offer unprecedented resolution for detecting profiling subsets based on features. However, existing single-cell technologies are use tubes well plates these platforms not easily scalable handling large number single cells. Here we demonstrate droplet-based microfluidic technology, Drop-BS, to construct...
Background: Osteosarcoma (OS) is a common malignant bone tumor in children and adolescents. DNA methylation plays crucial role the prognosis prediction of cancer. Identification novel sites biomarkers could be beneficial for OS patients. In this study, we aim to find an efficient methylated site model predicting survival OS. Methods: data were downloaded from Cancer Genome Atlas database (TCGA) GEO database. Cox proportional hazard regression random forest algorithm (RSFVH) applied identify...
BackgroundSecreted frizzled-related protein 5 (SFRP5) is a novel adipokine that has been found to be closely associated with metabolic and cardiovascular diseases. We investigated serum SFRP5 levels during the acute phase their predictive value for prognosis of aortic dissection (AAD).MethodsIn total, 152 AAD patients 164 controls were enrolled in this study. Serum measured using an enzyme-linked immunosorbent assay (ELISA). divided into high-SFRP5 low-SFRP5 groups based on optimal cutoff...
The erythroblast transformation-specific related gene (ERG) is expressed in hematopoietic stem and progenitor cells endothelial cells. This study aimed to investigate if ERG rs2836411 a novel genetic locus associated with anemia aortic dissection (AD). A case-control trial was conducted evaluate the association between polymorphism, anemia, AD risk. polymorphism analyzed using Sanger dideoxy chain termination sequencing on genomic DNA extracted from whole blood. Serum erythropoietin (EPO)...
Genome-wide DNA methylation profile, or methylome, is a critical component of the overall epigenomic landscape that modulates gene activities and cell fate. Single-cell methylomic studies offer unprecedented resolution for detecting profiling subsets based on features. However, existing single-cell technologies are all use tubes well plates these platforms not easily scalable handling large number single cells. Here we demonstrate droplet-based microfluidic technology, Drop-BS, to construct...