A5080744029- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Extracellular vesicles in disease
- Bone and Joint Diseases
- Tissue Engineering and Regenerative Medicine
- Hip disorders and treatments
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Hemostasis and retained surgical items
- Coconut Research and Applications
- Mesenchymal stem cell research
- Pelvic and Acetabular Injuries
- Reconstructive Facial Surgery Techniques
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Orthopaedic implants and arthroplasty
Xiangya Hospital Central South University
2023-2025
Central South University
2022-2025
BackgroundPerforator flaps are widely used in hand microsurgery to reconstruct and repair soft tissue injuries. However, ischemia subsequent ischemia-reperfusion injury may cause distal necrosis of the flap. Itaconic acid (IA) is a modulator macrophage function, which exerts anti-inflammatory effects activation.MethodsThe necrotic area flap was detected by measuring temperature with an infrared thermometer. Flap cell apoptosis TUNEL staining Western blot analysis apoptosis-associated...
Background: Multi-territory perforator flaps are a reconstructive measure for repairing large soft tissue defects caused by tumors or trauma. However, the use of these in clinical practice has been restricted due to uncertain blood supply. Therefore, promoting survival multi-territory flap is critical repair and reconstruction. In our study, we explored effects melatonin (MLT) on possible molecular mechanisms. Materials Methods: Seventy-two Sprague–Dawley rats (250–300 g) were randomly...
Iliac bone flap with deep circumflex iliac artery is a common option in the treatment of Osteonecrosis femoral head (ONFH), and dissection key step for successful operation. This paper aims to introduce new operative technique dissecting based on analysis its advantages.A total 49 patients treated by retrograde anatomy 52 anterograde from January 2010 December 2020 were recruited. The two groups then compared terms preoperative baseline conditions, intraoperative data, postoperative Harris...
Background Skin flap transplantation is used to effectively reconstruct defects of the hand and foot skin soft tissues. We here investigated effect PF127/bleomycin (BLM) hydrogel on extracellular matrix (ECM) remodeling flaps underlying mechanism, thereby providing a new reference point for personalized modification overcoming abrasion resistance- stability-associated difficulties.