A5086996718- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- Analytical Chemistry and Chromatography
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Protein purification and stability
- Microencapsulation and Drying Processes
- Advancements in Transdermal Drug Delivery
- 3D Printing in Biomedical Research
- Advanced Statistical Process Monitoring
- Polysaccharides Composition and Applications
- Pesticide Residue Analysis and Safety
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hydrogels: synthesis, properties, applications
- Antibiotics Pharmacokinetics and Efficacy
- Pain Management and Opioid Use
- Organophosphorus compounds synthesis
- Inhalation and Respiratory Drug Delivery
- Optimal Experimental Design Methods
Institut d'Investigació Biomédica de Bellvitge
2016-2025
Universitat de Barcelona
2016-2025
Universidad de Costa Rica
2024
Bellvitge University Hospital
2019
Duran i Reynals Hospital
2015-2019
Hospital de Viladecans
2018
Pharmaceutical Biotechnology (Czechia)
2016
The production of 3D printed pharmaceuticals has thrived in recent years, as it allows the generation customised medications small batches. This is particularly helpful for patients who need specific doses or formulations, such children. Compounding pharmacies seek alternatives to conventional solid oral doses, opting liquid formulations. However, ensuring quality and stability, especially pH-sensitive APIs like omeprazole, remains a challenge. paper presents application semi-solid extrusion...
Lipid-based nanoparticles are a useful tool for nucleic acids delivery and have been regarded as promising approach diverse diseases. However, off-targets effects matter of concern some strategies to improve selectivity solid lipid (SLNs) were reported. The goal this study was test formulations SLNs incorporating cholesteryl-9-carboxynonanoate (9CCN) "eat-me" signal target antagomiR oligonucleotides macrophages. We formulate four SLNs, those with mean diameter 200 nm Z-potential values...
Context: The SeDeM expert system is based on the experimental study and quantitative determination of characterization parameters powdered substances, aim being to determine whether a substance suitable for producing tablets by means direct compression (DC) technology, thereby reducing lead time pre-formulation studies. Additionally, this also provides formulations with minimum number excipients.Objective: We used analyze formulas production orodispersible ibuprofen tablets.Method:...
Although some methods for measuring bioadhesion/mucoadhesion have been proposed, a standardized method is not yet available. This expected to hinder systematic comparisons of results across studies. study aimed design single/systematic in vitro that applicable various pharmaceutical dosage forms. To this end, we measured the peak force and work adhesion minitablets, pellets, bioadhesive emulsion using texture analyzer. Porcine tissue was used simulate human stomach/skin conditions. The these...
Manufacturing lipid nanoparticles through microfluidic mixing can be approached from a Quality by Design perspective. Research involving critical process parameters seems to focus on the total flow and rate ratio, thus other variables, such as dialysis, are underestimated. This study used of Experiments identify influence particle size, polydispersity index, zeta potential. A response surface modeled of: (400 4000 μL min-1); ratio (3 9) dialysis (yes/no). Results suggest that is crucial...
The propose of the present study was to apply design experiments (DoE) develop an omeprazole enteric pellets suspension for use in paediatric population. This experimental employed a Full Factorial Design drug development, encompassing three factors (Aerosil® R972, cetostearyl alcohol, and Span 80) at two levels (2% 6% factor A R972) 2% 4% B C (cetostearyl alcohol 80, respectively)). Following statistical optimization, F10 formulated subjected stability one month. dissolution test results...
Background/Objectives: Carbamazepine is widely used as a first-line treatment for pediatric patients with benign epilepsy. However, most commercial formulations have doses of 100 mg or higher, limiting their suitability use. The aim this study was to develop mini orally disintegrating tablets (ODTs) containing 50 carbamazepine, utilizing direct compression technology, specifically tailored meet the unique needs patients. Methods: development carried out following Quality by Design (QbD)...
Simultaneous analysis with a single HPLC run allows for much more cost-effective and less time-consuming of skin-whitening cream.