A5064142406- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Nanocluster Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Metamaterials and Metasurfaces Applications
- HIV/AIDS drug development and treatment
- Quantum Dots Synthesis And Properties
- Spectroscopy and Quantum Chemical Studies
- RNA modifications and cancer
- Supramolecular Self-Assembly in Materials
- Characterization and Applications of Magnetic Nanoparticles
- Molecular spectroscopy and chirality
- Pancreatic and Hepatic Oncology Research
- Micro and Nano Robotics
- Pickering emulsions and particle stabilization
- Origins and Evolution of Life
- Plant and Biological Electrophysiology Studies
- Transition Metal Oxide Nanomaterials
- Material Dynamics and Properties
- Biochemical and Molecular Research
- Cephalopods and Marine Biology
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Infection Control and Ventilation
BioSurfaces (United States)
2019-2024
University of Michigan
2019-2024
China University of Geosciences (Beijing)
2024
Zhejiang University
2022-2024
Hangzhou First People's Hospital
2016-2024
Jilin University
1993-2023
State Key Laboratory of Supramolecular Structure and Materials
2016-2023
University of Chicago
2005-2018
Jilin Medical University
2016-2018
Howard Hughes Medical Institute
2007-2009
Nanorod alignment for optical asymmetry The high polarizability of chiral nanoassemblies plasmonic nanoparticles can lead to strong dichroism, but light scattering causes the fraction polarized photons generated, as measured by g-factors, be much lower than that liquid crystals. Lu et al. used supramolecular interactions gold nanorods with human islet amyloid peptides assemble metallic superstructures unusually cholesteric order (see Perspective Nam and Kim). long, straight helices increased...
Unique optical, electrical, and mechanical properties of continuous semiconductor helices with nanoscale mesoscale dimensions represent a previously unexplored materials platform for various applications requiring near-infrared (NIR) optical activity. However, current methods their synthesis limit the spectrum chiral geometries, charge transport, spectral response. Furthermore, requirements nearly perfect enantioselectivity, high uniformity, yield need to be attained as well. Here, we show...
Gold nanorods are excellent anisotropic building blocks for plasmonic chiral nanostructures. The near-infrared band of makes them highly desirable biomedical applications such as bioimaging and sensing, in which a strong circular dichroism (CD) signal is required. Chiral assemblies gold induced by self-associating peptides especially attractive this purpose they exhibit plasmonic-enhanced chiroptical activity. Here, we showed that the presence cetyltrimethylammonium bromide (CTAB) micelles...
Open AccessCCS ChemistryRESEARCH ARTICLE1 Feb 2022Gold Nanoparticle Enantiomers and Their Chiral-Morphology Dependence of Cellular Uptake Ning-Ning Zhang†, Hao-Ran Sun†, Shuhan Liu, Yu-Chen Xing, Jun Lu, Fei Peng, Cheng-Long Han, Zhonglin Wei, Tianmeng Sun, Bai Yang Kun Liu Zhang† State Key Laboratory Supramolecular Structure Materials, College Chemistry, Jilin University, Changchun 130012 , Sun† Organ Regeneration Transplantation Ministry Education, Institute Immunology, The First Hospital,...
Resistance to grape powdery mildew ( Uncinula necator BURR.) of 13 known Vitis species and 5 unclassified grapes native China was evaluated. 88 clones were tested with natural infection a subset 34 artificially inoculated during the years 1991-1992. 68 showed resistance U. . In general, we found V. bryoniifolia, davidii , piasezkii resistant However, intraspecific variations observed. Results from this study indicate that Chinese wild may provide valuable germplasm resources for resistance.
The catalytic mechanism by which the hairpin ribozyme accelerates cleavage or ligation of phosphodiester backbone RNA has been incompletely understood. There is experimental evidence for an important role adenine (A38) and a guanine (G8), it proposed that these act in general acid–base catalysis. In this work we show large reduction rate on substitution A38 purine (A38P) can be reversed replacement 5′-oxygen atom at scissile phosphate sulfur (5′-PS), much better leaving group. This...
Existing evidence suggests that the Varkud satellite (VS) ribozyme accelerates cleavage of a specific phosphodiester bond using general acid-base catalysis. The key functionalities are nucleobases adenine 756 in helix VI ribozyme, and guanine 638 substrate stem loop. This results bell-shaped dependence reaction rate on pH, corresponding to groups with p K = 5.2 8.4. However, it is not possible from those data determine which nucleobase acid, base. We have therefore made substrates 5′ oxygen...
A multi-Lorentzian-splitting algorithm is used to distinguish the <sup>1</sup>H NMR signal of free PEG from that grafted PEG, therefore allowing monitoring grafting process <italic>in situ.</italic>
A variety of inorganic nanoscale materials produce microscale particles with highly corrugated geometries, but the mechanism their formation remains unknown. Here we found that uniformly sized CdS-based hedgehog (HPs) self-assemble from polydisperse nanoparticles (NPs) diameters 1.0-4.0 nm. The typical HPs and spikes are 1770 ± 180 28 3 nm, respectively. Depending on temperature, solvent, reaction times, NPs into nanorods, nanorod aggregates, low-corrugation particles, other HP-related...
A zirconium-based bulk metallic glass, Zr41.2Ti13.8Cu12.5Ni10Be22.5 (Vit 1), and its composite, Zr56.3Ti13.8Cu6.9Ni5.6Nb5.0Be12.5 (β-Vit), were subjected to planar impact loading. surprisingly low amplitude elastic precursor wave, corresponding the response of “frozen structure” intact glasses, observed precede rate-dependent large deformation shock wave. concave downward curvature after initial increase Us–Up Hugoniots suggests that a phase-change-like transition occurred during...
A solitary fibrous tumor (SFT) is often located in the pleura, while SFT of pancreas extremely rare. Here, we report a case and discuss imaging, histopathology, immunohistochemistry for accurate diagnosis treatment.
Planck’s law ignores but does not prohibit black-body radiation (BBR) from being circularly polarized. BBR nanostructured filaments with twisted geometry nanocarbon or metal has strong ellipticity 500 to 3000 nanometers. The submicrometer-scale chirality of these satisfies the dimensionality requirements imposed by fluctuation-dissipation theorem and requires symmetry breaking in absorptivity emissivity according Kirchhoff’s law. resulting shows emission anisotropy brightness exceeding those...
Opposite chiralities were obtained <italic>via</italic> the self-assembly of gold nanorods induced by serum albumins from different species and pH modulation can reverse or enhance chiroptical behavior nanoassemblies.
In the structures of HDV ribozyme a cytosine nucleobase resides at active site poised to participate directly in catalysis. Defining functional role requires nucleoside analogues that perturb groups strategic manner. Herein, we have developed efficient methods for synthesis five C-nucleoside phosphoramidite derivatives that, when used combination, provide strategies probing potential cytosine's keto group and imino nitrogen. Phosphoramidites 15a 15b were synthesized 11 steps starting from...
Abstract The transfer of structural mirror asymmetry from chiral molecules to the inorganic phase at solid‐liquid interfaces enabled rapid development biomimetic nanoparticles. They can be synthesized and assembled following a variety chemical methods resulting in broad family nanostructures (CNs). Their chemistry attracted large attention due marked enhancement circular dichroism polarization rotation compared organic particles, which opened application prospects sensing, imaging,...
Reconfiguration of chiral ceramic nanostructures after ion intercalation should favor specific nanoscale twists leading to strong chiroptical effects. In this work, V2 O3 nanoparticles are shown have "built-in" distortions caused by binding tartaric acid enantiomers the nanoparticle surface. As evidenced spectroscopy/microscopy techniques and calculations chirality measures, Zn2+ ions into lattice results in particle expansion, untwist deformations, reduction. Coherent deformations ensemble...
Methyl 3,5-di-O-arylmethyl-alpha-D-ribofuranosides have been used extensively as synthons to construct 2'-C-branched ribonucleosides. Herein, we describe efficient access methyl (aryl: 2-ClC(6)H(4), 3-ClC(6)H(4), 4-ClC(6)H(4), 4-BrC(6)H(4), 2,4-Cl(2)C(6)H(3), Ph) in 72-82% yields from D-ribofuranoside. We also demonstrate the versatile precursor 3,5-di-O-benzyl-alpha-D-ribofuranoside (3f) and synthesis of 2'-C-beta-methoxymethyl- 2'-C-beta-ethoxymethyluridine six steps 3f with overall 18%...
Oligoribonucleotides containing a 5′-phosphorothiolate linkage have provided effective tools to study the mechanisms of RNA catalysis, allowing resolution kinetic ambiguity associated with mechanistic dissection and providing strategy establish between catalysis specific functional groups. However, challenges their synthesis limited wider application these modified nucleic acids. Here, we describe general semisynthetic obtain oligoribonucleotides reliably relatively efficiently. The approach...
Endonucleolytic ribozymes constitute a class of non-coding RNAs that catalyze single-strand RNA scission. With crystal structures available for all the known ribozymes, major challenge involves relating functional data to physically observed architecture. In case hepatitis delta virus (HDV) ribozyme, there are three high-resolution structures, product state reaction and two precursor variants, with distinct mechanistic implications. Here, we develop new strategies probe structure catalytic...
We report a facile yet general in situ seed-mediated method for the synthesis of polymer-grafted gold nanoparticles with narrow size distributions (<10%), accurately tunable sizes, and excellent colloidal stability. This can be extended to broad range types molecular weights polymer ligands. Nanoparticles different shapes also prepared by using preformed shaped directly as seeds.