Abstract Since December 2019, the clinical symptoms of coronavirus disease 2019 (COVID-19) and its complications are evolving. As number COVID patients requiring positive pressure ventilation is increasing, so incidence subcutaneous emphysema (SE). We report 10 COVID-19, with SE pneumomediastinum. The mean age was 59 ± 8 years (range, 23–75). Majority them were men (80%), common dyspnoea (100%), fever (80%) cough (80%). None had any underlying lung disorder. All acute respiratory distress...

To assess the knowledge, attitude, and practice of patients who underwent prone positioning during their COVID-19 illness in hospital.Cross-sectional study.Aga Khan University Hospital, Karachi, Pakistan.COVID-19-recovered patients.None.Knowledge was assessed by five questions with a dichotomous response (yes/no). An yes awarded 1 score. Since there were questions, would be highest Patients' perceptions therapy four each scored on Likert scale 5 (5 = strongly agree, 4 3 neither agree nor...

The objective was to identify predictors of mortality in hospitalized patients with Crimean-Congo hemorrhagic fever (CCHF). A case-control study conducted on CCHF from 2012 2022. Risk factors for were analyzed using logistic regression. total 86 a median age 36 years (interquartile range [IQR], 27-36 years) included, and the majority males (78, 90.7%). Thirty-one (36%) cases, whereas 55 (64%) control patients. Based univariate regression analysis, who an group ≥40 (odds ratio [OR]: 4.85; 95%...

SGLT-2 inhibitors have gained importance in recent years because of their cardio-protective and reno-protective properties diabetes. inhibitors, when introduced diabetic patients, may cause euglycemic ketoacidosis. A 55-year-old woman presented with low-grade fever, vomiting, lethargy. She was started on dapagliflozin two back. On workup, she diagnosed ketoacidosis (EDKA) managed accordingly. improved clinically while her stopped. With a literature search, we identified 15 case reports EDKA...

Introduction Epidemic of cardiovascular disease (CVD) is widely projected in South Asian population and estimated to get double two decades. Ischemic heart (IHD) one the spectrums CVD acute myocardial infarction (AMI) being common manifestations IHD. National Cardiovascular Data Registry (NCDR) a registry data that measure their practices improve quality care. In this project we aim see our performance trends care IHD including AMI patients over year’s period. Material & methods A cross...

Abstract Background Thyroid storm is an endocrine emergency and life-threatening condition discovered in 1926. There no specific laboratory parameter that can differentiate or distinguish between thyroid primary hyperthyroidism. Diagnosis made on a clinical scoring system, including the Burch–Wartofsky point scale Japanese Association system. The management early diagnosis, immediate initiation of anti-thyroid medications, intensive care monitoring, prevention multiorgan failure. Case...

A large number of patients worldwide have multimorbidity (two or more chronic diseases). In the past few decades, prevalence has been rising steeply and managing such is a challenge.[1][1] The majority these are admitted to step down units SDUs (rather

Background: The primary objective was to assess the change in oxygenation status of patients after remdesivir treatment. Material and Methods: This retrospective cross-sectional study conducted at Aga Khan University Hospital, Karachi from September December 2020. All aged >18 years admitted with a positive reverse transcriptase-polymerase chain reaction for COVID-19 were included. Infection severity subcategorized into two groups (moderate-to-severe critical). We compared assisted...

Abstract Introduction Intermediate care units (IMCUs) serve as step-up for emergency department patients and step-down critically ill transferred from intensive units. This study compares four critical illness scores assessment of acutely their accuracy in predicting mortality admitted to IMCU. Methods A comparative cross-sectional on aged ≥18 IMCU Aga Khan University Hospital 2017 2019. All the room were included study. Patient’s record reviewed demographic data, physiological laboratory...

Invasive Aspergillosis is a fungal infection caused by Aspergillus species, typically posing life-threatening risks to immunocompromised individuals. While occurrences in immunocompetent hosts are rare, recent case report documented fulminant pulmonary aspergillosis an patient during autopsy. Here, we present of invasive woman, manifesting with disseminated lesions.

Abstract Background Hyperammonemia is a medical condition described as increased or elevated serum ammonia levels. High levels of can cause neurotoxicity. Sudden onset severe hyperammonemia may encephalopathy with brain damage. It result in cerebral edema, emesis, seizures, hypotonia, and death. We report young postpartum woman who had sudden rise after vaginal delivery. Case presentation A 24-year-old, married, Pakistani was admitted to the intensive care unit through emergency department,...

A hospital-based cross-sectional study on COVID-19 confirmed patients was conducted at the Aga Khan University Hospital, Karachi, Pakistan, from April to June 2021. Presence of thrombosis in these compared with mortality. Platelet counts and D-dimer also among survivor non-survivor identify marker for severity disease.Sixty-six were enrolled mean age 62.3 years 45 (68.2%) male. Pulmonary embolism identified 32 (48.5%) while non-pulmonary occurred 5 admitted (7.6%). In our study, mortality 34...

Covid-19 associated pulmonary aspergillosis (CAPA) is a new entity and with high morbidity mortality. pro-inflammatory immunosuppressive disease, provoking fungal infections, especially by Aspergillus species. We describe the case of critically ill female patient, who was diagnosed CAPA infection acute respiratory distress syndrome (ARDS). She given intravenous Remdesivir. Her chest X-ray few days after admission showed multiple cavities. condition initially improved but deteriorated again,...

Tension pneumocephalus is a phenomenon in which air enters through dural injury the brain and then expands causes mass effect. The can be due to any neurosurgical procedure, trauma, infection and/or neoplasm. A 63-year-old female known case of diabetes hypertension had an elective procedure right dacryocystorhinostomy present emergency department very next day with loss consciousness. Urgent CT head showed cranium (pneumocephalus). radiological sign named "Mount Fuji" classical for tension...

To identify the association between acute infection and coronary syndrome, to evaluate outcomes in such cases.The cross-sectional, retrospective, analytical study was conducted at Aga Khan University Hospital, Karachi, from July December 2020, comprised data January 2019 of syndrome patients aged >18 years. Data related demographics, comorbidities, smoking status history dyslipidaemia. Binary logistic regression used explore infections with syndrome. analysed using SPSS 26.Of 1202 189(15.7%)...

Intermediate care units (IMCUs) serve as a bridge between general wards and intensive by providing close monitoring rapid response to medical emergencies. We aim identify the common acute conditions in patients admitted IMCU compare predicted mortality of these physiology chronic health evaluation-II (APACHE-II) score with actual mortality.A cross-sectional study was conducted at tertiary hospital from 2017 2019. All adult internal medicine IMCUs were included. Acute defined those short...

Sethi, Sher Muhammad; Hanif, Sadaf; Sabeen, Amber; Aqeel, Masooma; Zubairi, Ali Bin Sarwar Author Information

Background and study aim:In developing countries with high diabetes rates, it is essential to recognize the effect of infection on glycemic control.The purpose was determine how affects control, specifically HbA1c.The secondary objective compare infection-related outcomes between good versus poorly controlled diabetes.Methods: A cohort conducted from July 2019 June 2020 at Aga Khan University Hospital, Karachi.A patient's HbA1c before called preinfection HbA1c; after 3 months post-infection...