A5073860855- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Neonatal Health and Biochemistry
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Forensic Toxicology and Drug Analysis
- Advanced Breast Cancer Therapies
- Ethnobotanical and Medicinal Plants Studies
- Psidium guajava Extracts and Applications
- Drug Transport and Resistance Mechanisms
- Metabolism, Diabetes, and Cancer
- Natural Antidiabetic Agents Studies
- Cancer Genomics and Diagnostics
- Toxin Mechanisms and Immunotoxins
- Pharmacological Effects of Natural Compounds
- Herbal Medicine Research Studies
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Dye analysis and toxicity
- Enzyme-mediated dye degradation
- Cannabis and Cannabinoid Research
- Metabolomics and Mass Spectrometry Studies
- Dyeing and Modifying Textile Fibers
Government College Women University Faisalabad
2017-2022
Purdue University West Lafayette
2016
University of Agriculture Faisalabad
2015-2016
UDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes. The aim of this study was to explore the relationship between age and changes in mRNA expression activity major human hepatic UGTs, as well understand potential regulatory mechanism underlying relationship. Using previously generated data, we investigated age-dependent levels 11 UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A9, UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17) 16 transcription factors (AHR, AR,...
Interindividual variability in polymorphic uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1) ascribed to genetic diversity is associated with relative glucuronidation level among individuals. The present research was aimed study the effect of 2 important single nucleotide polymorphisms (SNPs; rs8330 and rs10929303) UGT1A1 gene on status acetaminophen healthy volunteers (n = 109). Among enrolled volunteers, 54.13% were male 59) 45.87% female 50). vivo activity investigated by...
In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such PubMed, Google scholar, home pages publishing groups, medical, clinical, and pharmaceutical sciences journals, well other relevant sources discover PD-1 expression cancer therapies also recurrence. The keywords used this search were autoimmunity, cell death, or...
The effect of acetaminophen on sulfamethazine N-acetylation by human N-acetyltrasferase-2 (NAT2) was studied in 19 (n = 19) healthy male volunteers two different phases. In the first phase study were given an oral dose 500 mg alone and blood urine samples collected. After 10-day washout period same selected again administered along with 1000 acetaminophen. acetylation NAT2 both phases without determined HPLC to establish their respective phenotypes. conclusion obtained statistics present...
Natural medicines are being used for the treatment of various disorders due to pharmacological, therapeutical, and nutraceuticals characteristics.Current research was planned explore In vitro pharmacological response phytochemical constituents extracted from C. monnieri' seeds using aqueous ethanol (70%).Qualitative quantitative measurements were performed following reference protocols. Then antioxidant potential, cytotoxic studies, antimicrobial, spermicidal monnieri extract...